Fenfluramine challenge test as a marker of serotonin activity in patients with Alzheimer's dementia and agitation

Biological Psychiatry

Volumn 44, Issue 9, 1998, Pages 918-921

  Mintzer, Jacobo ^a   Brawman Mintzer, Olga ^a   Mirski, Dario F ^a   Unger, Richard ^a   Nietert, Paul ^b   Meeks, Allison ^a   Sampson, Royce ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Center for Health Care Research   (United States)

Author keywords

Aggression; Agitation; Alzheimer's disease; Dementia; Fenfluramine; Serotonin

Indexed keywords

FENFLURAMINE; LORAZEPAM; NORFENFLURAMINE; PROLACTIN;

AGED; AGGRESSION; AGITATION; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; DISEASE ASSOCIATION; DRUG EFFICACY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; SEROTONIN RELEASE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BEHAVIORAL SYMPTOMS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; FENFLURAMINE; HUMANS; MALE; PROLACTIN; PSYCHOMOTOR AGITATION; SEROTONIN; SEROTONIN AGENTS;

EID: 0032213211     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00004-3     Document Type: Article

References (21)

1. Alexopoulous G.S., Abrams R.C., Young R.C., et al. Cornell scale for depression in dementia. Biol Psychiatry. 23:1988;271-284.
2. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, rev. Washington, DC American Psychiatric Press, pp 103-105.
3. Brown G.L., Ebert M.H., Goyer P.F., Jimerson D.C., Klein W.J., Bunney W.E., Goodwin F.K. Aggression, suicide, and serotonin Relationships to CSF amine metabolites . Am J Psychiatry. 139:1982;741-746.
4. Coccaro E.F., Siever L.J., Klar H.M., et al. Serotonergic studies in patients with affective and personality disorders Correlates with suicidal and impulsive aggressive behavior . Arch Gen Psychiatry. 46:1989;587-599.
5. Cohen-Mansfield J. Agitated behavior in the elderly II. Preliminary results in the cognitively deteriorated. JAGS. 10:1986;722-727.
6. Cohen-Mansfield J., Marx M.S., Rosenthal A.S. A description of agitation in a nursing home. J Gerontol Med Sci. 44:1989;77-84.
7. Gottfries C.G., Gottfries I., Roos B.E. Homovanillic acid and 5-hydroxyindoleacetic acid in the cerebrospinal fluid of patients with senile dementia, presenile dementia, and parkinsonism. J Neurochem. 16:1969;1341-1345.
8. Krebs H.A., Chens L.K., Wright G.J. Determination of fenfluramine and norfenfluramine in plasma using a nitrogen-sensitive detector. J Chromatogr. 310:1984;412-417.
9. Lanctot KL, Hermann N, Naranjo CA, van Reekum R, Eryavec G, Shulman RW (1997): Role of serotonin in aggressive behaviors associated with Alzheimer's Disease-preliminary results. Psychopharmacol Bull 33:3, 545.
10. McKahnn G., Drachman D., Folstein M., et al. Clinical diagnosis of Alzheimer's disease Report of the NINCDS-ADRDA workshop under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease . Neurology. 34:1984;939-944.
11. McLoughlin D.M., Lucey J.V., Dinan T.G. Central serotoninergic hyperresponsivity in late-onset Alzheimer's disease. Am J Psychiatry. 151:1994;1701-1703.
12. Maes M., D'Hondt P., Suy E., Minner B., Vandervoist C., Raus J. HPA-axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls. Prog Neuro-Psychopharmacol Biol Psychiatry. 15:1991;781.
13. Mintzer J.E., Unger R., Bachman D., Meeks A. Serotonin function in demented agitated persons. Psychopharmacol Bull. 32:1996;490.
14. Nyth A.L., Gottfries C.G. The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders A Nordic multicentre study . Br J Psychiatry. 157:1990;894-901.
15. Procter A.W., Francis P.T., Stratmann G.C., Bowen D.M. Serotonergic pathology is not widespread in Alzheimer's patients without prominent aggressive symptoms. Neurochem Res. 17:1992;917-922.
16. Quattrone A., Schettini G., di Renzo G.H., et al. Effect of midbrain raphe lesion or 5-7-dihydroxytryptamine treatment on the prolactin releasing action of quipazine and d-fenfluramine in rats. Brain Res. 174:1979;71-79.
17. Quattrone A., Tedeschi A., Aguglia U., et al. Prolactin secretion in man A useful tool to evaluate the activity of drugs on central 5-hydroxytryptaminergic neurones: Studies with fenfluramine . Br J Clin Pharmacol. 16:1983;471-475.
18. Rowland N.E., Carlton J. Neurobiology of an anorectic drug Fenfluramine . Prog Neurobiol. 27:1986;13-62.
19. Smith C.C., Bowen D.M., Simns N.R., et al. Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease. Brain Res. 264:1983;138-141.
20. Soininen H., MacDonald E., Rekonen M., et al. Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer's type. Acta Neurol Scand. 64:1981;101-107.
21. Yen C.Y., Stangler R.L., Millman N. Atarctic suppression of isolation-induced aggressive behavior. Arch Int Pharmacodyn Ther. 123:1959;179-185.