Animal models for studying serotonin (5-HT) receptor subtypes: Relationship to 5-HT system pathologies

Nuclear Medicine and Biology

Volumn 25, Issue 8, 1998, Pages 747-749

  Ogren S O ^a   Misane, I ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

5 HT receptors; 5 HT uptake; 8 OH DPAT; Animal models; Anxiety; Passive avoidance

Indexed keywords

SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; AVERSIVE BEHAVIOR; CONFERENCE PAPER; MALE; NONHUMAN; PASSIVE AVOIDANCE; PROTEIN DETERMINATION; RAT; RECEPTOR DENSITY; SYNAPTIC TRANSMISSION; TASK PERFORMANCE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANXIETY; AVOIDANCE LEARNING; DISEASE MODELS, ANIMAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 0032212685     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(98)00067-5     Document Type: Conference Paper

References (10)

1. Dawson G.R., Tricklebank M.D. Use of the elevated plus maze in the search for novel anxiolytic activity. TIPS. 16:1995;33-36.
2. 3 receptor antogonists A critical update on therapeutic potential . TIPS. 14:1993;267-270.
3. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders More than 30 years of research . Pharmacol. Ther. 63:1995;319-395.
4. Handley S.L., McBlanc J.W. 5-HT drugs in animal models of anxiety. Psychopharmacology. 112:1993;13-20.
5. Hjorth S., Carlsson A., Lindberg P., Sanchez D., Wikström H., Arvidsson L.E., Hacksell U., Nilsson J.L.G. 8-Hydroxy-2-(di-n-propyloamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT receptor stimulating activity. J. Neural. Transm. 55:1982;169-188.
6. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P.A. VII. International Union of Pharmacology, classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
7. Iversen S.D. 5-HT and anxiety. Neuropharmacology. 23:1984;1553-1560.
8. 1A receptor involvement in passive avoidance in the rat. Br. J. Pharmacol. 1998;. (In press.).
9. Ogren S.O. Evidence for a role of brain serotoninergic neurotransmission in avoidance learning. Acta Physiol. Scand. 125:(suppl. 544):1985;7-71.
10. Villalon C.M., Terron J.A., Ramirez-San Juan E., Saxena P.R. 5-Hydroxytryptamine Considerations about discovery, receptor classification and relevance to medical research . Arch. Med. Res. 26:1995;331-344.