Evaluation of live, cold-adapted influenza A and B virus vaccines in elderly and high-risk subjects

Vaccine

Volumn 16, Issue 18, 1998, Pages 1756-1760

  Treanor, John J ^a   Betts, Robert F ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Clinical trials; Elderly; Influenza; Live attenuated vaccine

Indexed keywords

INFLUENZA VACCINE;

ADULT; AGED; ANTIBODY TITER; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; GERIATRIC CARE; HIGH RISK POPULATION; HUMAN; IMMUNE RESPONSE; IMMUNOASSAY; INFLUENZA; INFLUENZA VIRUS A; INFLUENZA VIRUS B; INTRAMUSCULAR DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; ANTIBODIES, VIRAL; COLD; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMAGGLUTINATION TESTS; HUMANS; INFLUENZA A VIRUS; INFLUENZA B VIRUS; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED; NURSING HOMES; VACCINES, ATTENUATED;

EID: 0032212458     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00136-4     Document Type: Article

References (15)

1. 1 Murphy, B.R. Use of live, attenuated cold-adapted influenza A reassortant virus vaccines in infants, children, young adults and elderly adults. Infect. Dis. Clin. Pract. 1993, 2, 176-181.
2. 2 Edwards, K.M., Dupont, W.D., Westrich, M.K., Plummer, W.D.J., Palmer, P.S. and Wright, P.F. A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease. J. Infect. Dis. 1994, 169, 68-76.
3. 3 Belshe, R., Mendelman, P., Treanor, J. et al. The efficacy of live attenuated cold-adapted trivalent intranasal influenza virus vaccine in children. N. Engl. J. Med. 1998, 358, 1405-1412.
4. 4 Atmar, R.L., Bloom, K., Keitel, W., Couch, R.B. and Greenberg, S.B. Effect of live attenuated, cold recombinant (CR) influenza virus vaccines on pulmonary function in healthy and asthmatic adults. Vaccine 1990, 8, 217-224.
5. 5 Gorse, G.J., Belshe, R.B. and Munn, N.J. Local and systemic antibody responses in high-risk adults given live attenuated and inactivated influenza A virus vaccines. J. Clin. Microbiol. 1988, 26, 911-918.
6. 6 Gorse, G.J. and Belshe, R.B. Enhancement of anti-influenza A virus cytotoxicity following influenza A vaccination in older, chronically ill adults. J. Clin. Microbiol. 1990, 28, 2539-2550.
7. 7 Gorse, G.J., Belshe, R.B. and Munn, N.J. Superiority of live attenuated compared with inactivated influenza A virus vaccines in older, chronically ill adults. Chest 1991, 100, 977-984.
8. 8 Powers, D.C., Sears, S.D., Murphy, B.R., Thuman, B. and Clements, M.L. Systemic and local antibody responses in elderly subjects given live or inactivated influenza A virus vaccines. J. Clin. Microbiol. 1989, 27, 2666-2671.
9. 9 Powers, D.C., Fries, L.F., Murphy, B.R., Thumar, J.B. and Clements, M.L. In elderly persons live attenuated influenza A virus vaccines do not offer an advantage over inactivated virus vaccine in inducing serum or secretory antibodies or local immunologic memory. J. Clin. Microbiol. 1991, 29, 498-505.
10. 10 Powers, D.C., Murphy, B.R., Fries, L., Adler, W.H. and Clements, M.L. Reduced infectivity of cold-adapted influenza A H1N1 viruses in the elderly: correlation with serum and local antibodies. J. Am. Geriatrics Soc. 1992, 40, 163-167.
11. 11 Murphy, B.R., Phelan, M.E. and Nelson, D.L. et al. Hemagglutinin specific enzyme linked immunosorbent assay for antibodies to influenza A and B viruses. J. Clin. Microbiol. 1981, 13, 554-560.
12. 12 Treanor, J., Dumyati, G. and O'Brien, D. et al. Evaluation of cold-adapted, reassortant influenza B virus vaccines in elderly and chronically ill adults. J. Infect. Dis. 1994, 169, 402-407.
13. 13 Gorse, G.J., Otto, E.E., Powers, D.C., Chambers, G.W., Eickhoff, C.S. and Newman, F.K. Induction of mucosal antibodies by live attenuated and inactivated influenza vaccines in the chronically ill elderly. J. Infect. Dis. 1996, 173, 285-290.
14. 14 Treanor, J.J., Mattison, H.R. and Dumyati, G. et al. Protective efficacy of combined live intranasal and inactivated influenza A virus vaccines in the elderly. Ann. Internal Med. 1992, 117, 625-633.
15. 15 Gorse, G.J., Campbell, M.J., Otto, E.E., Powers, D.C., Chambers, G.W. and Newman, F.K. Increased anti-influenza cytotoxic T cell activity following vaccination of the chronically ill elderly with live attenuated or inactivated influenza virus vaccine. J. Infect. Dis. 1995, 172, 1-10.