High-resolution analysis of cytosine methylation in the 5' long terminal repeat of retroviral vectors

Human Gene Therapy

Volumn 9, Issue 16, 1998, Pages 2321-2330

  Wang, Lijun ^b   Robbins, Paul B ^b   Carbonaro, Denise A ^b   Kohn, Donald B ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DINUCLEOTIDE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EMBRYONAL CARCINOMA; EXPRESSION VECTOR; FIBROBLAST CULTURE; GENE EXPRESSION; LONG TERMINAL REPEAT; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NONHUMAN; RETROVIRUS;

EID: 0032211237     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.16-2321     Document Type: Article

References (9)

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2. APPERLEY, J.F., LUSKEY, B.D., and WILLIAMS, D.A. (1991). Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells: Effect of selectable marker sequences on long-term expression. Blood 78, 310-317.
3. BARKLIS, E., MULLIGAN, R.C., and JAENISCH, R. (1986). Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells Cell 47, 391-399.
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7. BRANDEIS, M., FRANK, D., KESHET, I., SIEGFRIED, Z., MENDELSOHN, M., NEMES, A., TEMPER, V., RAZIN, A., and CEDAR, H. (1994). Sp1 elements protect a CpG island from de novo methylation. Nature (London) 371, 435-438.
8. CEDAR, H. (1988). DNA methylation and gene activity: Minireview. Cell 53, 3-1.
9. CHALLITA, P.M., and KOHN, D.B. (1994). Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation. Proc. Natl. Acad. Sci. U.S.A. 91, 2567-2571.