Effects of the immunostimulant, levamisole, on opiate withdrawal and levels of endogenous opiate alkaloids and monoamine neurotransmitters in rat brain

Neuropsychopharmacology

Volumn 19, Issue 5, 1998, Pages 417-427

  Spector, Sydney ^a   Munjal, Inam ^a   Schmidt, Dennis E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Codeine; Immunostimulation; Levamisole; Morphine; Narcotic addiction

Indexed keywords

BRAIN MONOAMINE; CODEINE; DOPAMINE; ENDORPHIN; LEVAMISOLE; MONOAMINE; MORPHINE; MURAMYL DIPEPTIDE; NALTREXONE; NEUROTRANSMITTER; NORADRENALIN; OPIATE; SEROTONIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE METABOLISM; DRUG WITHDRAWAL; IMMUNOSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RAT; SEROTONIN METABOLISM; SUBCUTANEOUS DRUG ADMINISTRATION;

ADJUVANTS, IMMUNOLOGIC; ANALGESICS, OPIOID; ANIMALS; BIOGENIC MONOAMINES; BRAIN; DOPAMINE; LEVAMISOLE; LUNG; MALE; MORPHINE; MYOCARDIUM; NARCOTICS; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SPLEEN; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0032210887     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(98)00034-7     Document Type: Article

References (26)

1. Bessedovsky H., Del Rey A., Sorkin E., Dimarello C.A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 233:1986;652-654.
2. Bettner-Johnson D., Nestler E.J. Morphine and codeine exert common chronic action in tyrosine hydroxylase in dopaminergic reward regions. J Neurochem. 51:1991;344-347.
3. Bianchi E., Guarna M., Tagliamonte A. Immunocytochemical localization of endogenous codeine and morphine. Adv Neuroimmunol. 4:1994;83-92.
4. Brown C.E., Roerig S.C., Burger V.T., Cody R.B., Fujimoto J.M. Analgesic potencies of morphine - 3 and 6 sulfates after intracerebroventricular administration in mice. Relationship to structural characteristics defined by mass spectrometry and nuclear magnetic resonance. J Pharmaceut Sci. 74:1985;821-824.
5. Dafny N., Zielinski M., Reyes-Vazquez C. Alteration of morphine withdrawal to naloxone by interferon. Neuropeptides. 3:1983;453-463.
6. Del Giaco G.S., Tognella S., Leone A.L. Interference of levamisole with inhibition of E. Rosette formation by Hodgkins disease and systemic lupus erythematosis cytotoxic serum. Blood. 53:1979;1002-1007.
7. Dole V.P., Nyswander M.E. A medical treatment for diacetyl-morphine (heroin) addiction. JAMA. 193:1965;646-650.
8. Donnerer J., Oka K., Brossi A., Rice K.C., Spector S. Presence and formation of codeine and morphine in the rat. Proc Natl Acad Sci USA. 83:1986;4560-4567.
9. Donnerer J., Cardinale G., Coffey J., Lisek C.A., Lardine I., Spector S. Chemical characterizations and regulation of endogenous morphine and codeine in the rat. J Pharmacol Exp Ther. 242:1987;583-587.
10. Dougherty P.M., Drath D.B., Dafny N. Evidence of an immune system to brain communication axis that affects central opioid function. Muramyl peptides attenuates opiate withdrawal Eur J Pharmacol. 141:1987;253-260.
11. Ernstrom U., Soder O. Influence of adrenaline on the dissemination of antibody producing cells from the spleen. Clin Exp Immunol. 21:1975;131-140.
12. Felton D.L., Felton S.Y., Carlson S.L., Olshowska J.A., Liviat S. Noradrenergic and peptidergic innervation of lymphoid tissue. J Immunol. 135:1985;755-765.
13. Goldstein A., Barrett R.W., James I.F., Lowey L.I., Weitz C.J., Kimpmeyer L.L., Rapoport H. Morphine and other opiates from beef brain and adrenals. Proc Natl Acad Sci USA. 82:1985;5203-5207.
14. Herman B.H., O'Brien C.P. Clinical medications development for opiate addiction. focus on nonopioids and opioid antagonists for the amelioration of opiate withdrawal symptoms and relapse prevention Sem Neurosci. 9:1997;158-172.
15. Janssen P.A. The levamisole story. Tucker E. Progress in Drug Research. 1976;1-66 Springer, New York.
16. Marx J.L. Cancer immunotherapy. Focus on the drug levamisole Science. 191:1976;57.
17. Moertel C.G., Fleming T.R., Macdonald S.S. Levamisole and fluouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 322:1990;352-358.
18. Munjal I.D., Schmidt D., Spector S. Role of endogenous morphine in the attenuation of opiate withdrawal syndrome by N-acetylmuramyl-L alanine-D-isoglutamine (MDP). Neuropsychopharmacology. 15:1996;99-103.
19. O'Dorisio M.S., Wood C.L., O'Dorisio T.M. Vasoactive intestinal peptides and neuropeptides modulation of the immune response. J Immunol. 135:1985;792-796.
20. Oka K., Kantrowitz J.D., Spector S. Isolation of morphine from toad skin. Proc Natl Acad Sci USA. 82:1985;1852-1854.
21. Payan D.G., Goetzel E.J. Modulation of lymphocyte factor by sensory neuropeptides. J Immunol. 135:1985;783-786.
22. Pfeifer A.O., Samson H.H. Haloperidol and apomorphine effects on ethanol reinforcement in the feeding rats. Pharmacol Biochem Behav. 24:1988;343.
23. Renoux G. The general immunopharmacology of levamisole. Drugs. 19:1980;89-99.
24. Schmidt D., Roznoski M.L., Ebert M.H. Quantitative and qualitative HPLC analysis of monoamine neurotransmitters and metabolites in CSF and brain tissues using reductive electrochemical detection. Biochem Chromatog. 4:1990;215.
25. Symens J., Rosenthal M. Levamisole in the modulation of the immune response. The current experimental and chemical state. I. Reticuloendothelial Soc. 21:1977;175-221.
26. Wise R.A. The brain and reward. Cietman J.M., Cooper S.J. The Neuropharmacological Basis of Reward. 1989;Oxford University Press, p 377, Oxford.