Identifying the principal protective antigenic determinants of type a botulinum neurotoxin

Vaccine

Volumn 16, Issue 19, 1998, Pages 1850-1856

  Bavari, S ^a   Pless, Dorothy D ^a   Torres, Edna R ^a   Lebeda, Frank J ^a   Olson, Mark A ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Botulinum neurotoxins; Neutralizing monoclonal antibodies; Principal protective antigenic determinants; Vaccine

Indexed keywords

BOTULINUM TOXIN A; EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGENICITY; CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; BACTERIAL VACCINES; BOTULINUM TOXIN TYPE A; EPITOPES; FEMALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

EID: 0032210752     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00175-3     Document Type: Conference Paper

References (18)

1. 1 Montecucco, C. and Schiavo, G. Structure and function of tetanus and botulinum neurotoxins. Q. Rev. Biophys. 1995, 28, 423-472.
2. 2 Hatheway, C.L. and Ferreira, J.L. Detection and identification of Clostridium botulinum neurotoxins. Adv. Exp. Med. Biol. 1996, 391, 481-498.
3. 3 Coffield, J.A., Bakry, N., Zhang, R.-D., Carlson, J., Gomella, L.G. and Simpson, L.L. In vitro characterization of Botulinum toxin Types A, C and D action on human tissues: combined electrophysiologic, pharmacologic and molecular biologic approaches. J. Pharm. Exp. Therap. 1997, 280, 1489-1498.
4. 4 Montecucco, C., Schiavo, G., Tugnoli, V. and de-Grandis, D. Botulinum neurotoxins: mechanism of action and therapeutic applications. Mol. Med. Today 1996, 2, 418-424.
5. 5 Tonello, F., Morante, S., Rossetto, O., Schiavo, G. and Montecucco, C. Tetanus and botulism neurotoxins: a novel group of zinc-endopeptidases. Adv. Exp. Med. Biol. 1996, 389, 251-260.
6. 6 Dolly, J.O., Ashton, A.C., Evans, D.M., Richardson, P.J., Black, J.D. and Melling, J. Molecular action of botulinum neurotoxins: role of acceptors in targeting to cholinergic nerves and in the inhibition of release of several transmitters. In Cellular and Molecular Basis of Cholinergic Function (Ed. Dowdall, M.J.). Ellis Horwood, Chichester, 1987, pp. 517-533.
7. 7 Dertzbaugh, M.T. and West, M.W. Mapping of protective and cross-reactive domains of the type A neurotoxin of Clostridium botulinum. Vaccine 1996, 14, 1538-1544.
8. 8 Clayton, M.A., Clayton, J.M., Brown, D.R. and Middllebrook, J.L. Protective vaccination with a recombinant fragment of Clostridium botulinum neurotoxin serotype A expressed from a synthetic gene in Escherichia Coli. Infect. Immun. 1995, 63, 2738-2742.
9. 9 Lebeda, F.J. and Olson, M.A. Secondary structural predictions for the clostridial neurotoxins. Proteins: Struct. Funct. Gen. 1994, 20, 293-300.
10. 10 Ulrich, R.G., Bavari, S. and Olson, M.A, Bacterial superantigens in human disease: structure, function and diversity. Trends Microbiol. 1995, 3, 463-468.
11. 11 Sander, C. and Schneider, R. Database of homology-derived structures and the structural meaning of sequence alignment. Proteins 1991, 9, 56-68.
12. 12 Rost, B. and Sander, C. Combining evolutionary information and neural networks to predict protein secondary structure. Proteins: Struct. Funct. Gen. 1994, 19, 55-72.
13. 13 Rost, B. and Sander, C. Conservation and prediction of solvent accessibility in protein families. Proteins: Struct. Funct. Gen. 1994, 20, 216-226.
14. 14 Lebeda, F.J. and Olson, M.A. Structural predictions of the channel-forming region of botulinum neurotoxin heavy chain. Toxicon 1995, 33, 559-567.
15. 15 Lebeda, F.J. and Olson, M.A. Predicting differential antigen-antibody contact regions based on solvent accessibility. J. Prof. Chem. 1997, 16, 607-618.
16. 16 Lebeda, F.J., Umland, T.C., Sax, M. and Olson, M.A. Accuracy of secondary structure and solvent accessibility predictions for a clostridial neurotoxin C-fragment. J. Prot. Chem. 1998, 17, 311-318.
17. c of Tetanus neurotoxin. Nature Struct. Biol. 1997, 4, 788-791.
18. 18 Atassi, M.Z., Dolimbek, B.Z., Hayakari, M., Middlebrook, J.L., Whitney, B. and Oshima, M. Mapping of the antibody-binding regions on Botulinum neurotoxin H-chain domain 855-1296 with antitoxin antibodies from three host species. J. Prot. Chem. 1996, 15, 691-700.