Mechanism of Increased Serum Cytokeratin 19 Fragment Levels in Patients with Diabetic Nephropathy as a Model of Chronic Renal Failure

Internal Medicine

Volumn 37, Issue 11, 1998, Pages 917-921

  Kashiwabara, Kosuke ^a   Kishi, Koji ^a   Nakamura, Hiroyuki ^a   Yagyu, Hisanaga ^a   Kobayashi, Katsuyuki ^a   Watanabe, Osamu ^a   Matsuoka, Takeshi ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Metabolic failure; Urinary albumin; Urinary cytokeratin 19 fragment (CYFRA 21 1); Urinary immunoglobulin G; Urinary transferrin

Indexed keywords

ANTIGEN CYFRA21.1; CREATININE; IMMUNOGLOBULIN G; KERATIN; TRANSFERRIN; TUMOR ANTIGEN; TUMOR MARKER;

ALBUMINURIA; ARTICLE; BLOOD; CHRONIC KIDNEY FAILURE; COMPARATIVE STUDY; DIABETIC NEPHROPATHY; FEMALE; HOSPITALIZATION; HUMAN; IMMUNORADIOMETRIC ASSAY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PROGNOSIS; URINE;

ALBUMINURIA; ANTIGENS, NEOPLASM; CREATININE; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNORADIOMETRIC ASSAY; KERATINS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PROGNOSIS; SEVERITY OF ILLNESS INDEX; TRANSFERRIN; TUMOR MARKERS, BIOLOGICAL;

EID: 0032201561     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.37.917     Document Type: Article

References (17)

1. Broers JV, Ramaekers FC, Rot MK, et al. Cytokeratins in different types of human lung cancer as monitored by chain-specific monoclonal antibodies. Cancer Res 48: 3221-3229, 1988.
2. Moll R, Franke WW, Schiller DL, Geiger B, Krepier R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31: 11-24, 1982.
3. Molina R, Agusti C, Filella X. et al. Study of a new tumor marker. CYFRA 21-1, in malignant and nonmalignant diseases. Tumor Biol 15:318-325, 1994.
4. Rastel D, Ramaioli A, Cornillie F, Thirion B, and CYFRA 21-1 multicentre study group. CYFRA 21-1, a sensitive and specific new tumour marker for squamous cell lung cancer. Report of the first european multicentre evaluation. Eur J Cancer 30A: 601-606, 1994.
5. Sarwar M, Tomiyoshi K, Inoue T, Fukazawa K, Endo K. CYFRA 21-1 as a tumor marker used in measuring the serum fragment of cytokeratin subunit 19 by immunoradiometric assay. Ann Nucl Med 8: 301-306, 1994.
6. Deen WM, Satvat B. Determinants of the glomerular filtration of proteins. Am J Physiol 241: F162-F170, 1981.
7. Brenner BM, Hostetter TH, Humes HD. Molecular basis of proteinuria of glomerular origin. N Engl J Med 298: 826-833, 1978.
8. Myers BD, Winetz JA, Chui F, Michaels AS. Mechanisms of proteinuria in diabetic nephropathy: A study of glomerular barrier function. Kidney Int 21: 633-641, 1982.
9. Viberti G, Mackintosh D, Keen H. Determinants of the penetration of proteins through the glomerular barrier in insulin-dependent diabetes mellitus. Diabetes 32 Suppl 2: 92-95, 1983.
10. Carrie BJ, Myers BD. Proteinuria and functional characteristics of the glomerular barrier in diabetic nephropathy. Kidney Int 17: 669-676, 1980.
11. Friedman S, Jones HW, Golbetz HV, Lee JA, Little HL, Myers BD. Mechanisms of proteinuria in diabetic nephropathy II. A study of size-selective glomerular filtration barrier. Diabetes 32 Suppl 2:40-46, 1983.
12. Winetz JA, Golbetz HV, Spencer RJ, Lee JA, Myers BD. Glomerular function in advanced human diabetic nephropathy. Kidney Int 21: 750-756, 1982.
13. Parthasarathy N, Spiro RG. Effect of diabetes on the glycosaminoglycan component of the human glomerular basement membrane. Diabetes 31: 738-741, 1982.
14. O'Donnell MJ, Martin P, Florkowski CM, et al. Urinary transterrin excretion in type 1 (insulin-dependent) diabetes mellitus. Diabet Med 8: 657-661, 1991.
15. Fuchs E. Keratins as biochemical markers of epithelial differentiation. Trends Genet 4: 227-281, 1988.
16. Bernard AM, Amor AA, Goemaere-Vanneste J, et al. Microtransferrinuria is a more sensitive indicator of early glomerular damage in diabetes than microalbuminuria. Clin Chem 34: 1920-1921, 1998.
17. Martin P, Walton C, Chapman C, Bodansky HJ, Stickland MH. Increased urinary excretion of transferrin in children with type I diabetes mellitus. Diabet Med 7: 35-40, 1990.