Epstein-Barr virus polymerase chain reaction and serology in pediatric post-transplant lymphoproliferative disorder: Three-year experience

Pediatric and Developmental Pathology

Volumn 1, Issue 6, 1998, Pages 480-486

  Rogers, Beverly Barton ^a,b   Sommerauer, John ^a   Quan, Albert ^a   Timmons, Charles F ^a   Dawson, D Brian ^b   Scheuermann, Richard H ^b   Krisher, Karen ^a   Atkins, Carolyn ^a  

^a CHILDREN S MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Epstein Barr virus; Lymphoproliferative disorder; Polymerase chain reaction; Serology

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; EPSTEIN BARR VIRUS ENCODED RNA 1; EPSTEIN-BARR VIRUS ENCODED RNA 1; VIRUS ANTIBODY; VIRUS DNA; VIRUS RNA;

ARTICLE; CHILD; COMPARATIVE STUDY; EPSTEIN BARR VIRUS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HERPES VIRUS INFECTION; HUMAN; IMMUNOLOGY; IN SITU HYBRIDIZATION; INFANT; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; METHODOLOGY; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; SEROLOGY; VIRUS INFECTION;

ANTIBODIES, VIRAL; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; IN SITU HYBRIDIZATION; INFANT; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISORDERS; POLYMERASE CHAIN REACTION; RNA, VIRAL; SEROLOGIC TESTS; TUMOR VIRUS INFECTIONS;

EID: 0032200375     PISSN: 10935266     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100249900066     Document Type: Article

References (17)

1. Craig FE, Gulley ML, Banks PM. Posttransplantation lymphoproliferative disorders. Am J Clin Pathol 1993;99: 265-276.
2. Leblond V, Sutton L, Dorent R, et al. Lymphoproliferative disorders after organ transplantation: a report of 24 cases observed in a single center. J Clin Oncol 1995;13:961-968.
3. Cox KL, Lawrence-Miyasaki LS, Garcia-Kennedy R, et al. An increased incidence of Epstein-Barr virus infection and lymphoproliferative disorder in young children on FK506 after liver transplantation. Transplantation 1995;59:524-529.
4. Riddler SA, Breinig MC, McKnight JLC. Increased levels of circulating Epstein-Barr virus (EBV)-infected lymphocytes and decreased EBV nuclear antigen antibody responses are associated with the development of posttransplant lymphoproliferative disease in solid-organ transplant recipients. Blood 1994;84:972-984.
5. Preiksaitis JK, Diaz-Mitoma F, Mirzayans F, Roberts S, Tyrrell DO. Quantitative oropharyngeal Epstein-Barr virus shedding in renal and cardiac transplant recipients: relationship to immunosuppressive therapy, serologic responses, and the risk of posttransplant lymphoproliferative disorder. J Infect Dis 1992;166:986-994.
6. Lamy ME, Favart AM, Cornu C, et al. Epstein-Barr virus infection in 59 orthotopic liver transplant patients. Med Microbiol Immunol 1990;179:137-144.
7. Green M, Reyes J, Jabbour N, et al. Use of quantitative PCR to predict onset of Epstein-Barr viral infection and posttransplant lymphoproliferative disease after intestinal transplantation in children. Trans Proc 1996;28:2759-2760.
8. Kenagy DN, Schlesinger Y, Weck K, Ritter JH, Gaudreault-Keener MM, Storch GA. Epstein-Barr virus DNA in peripheral blood leukocytes of patients with posttransplant lymphoproliferative disease. Transplantation 1995;60:547-554.
9. Telenti A, Marshall WF, Smith TF. Detection of Epstein-Barr virus by polymerase chain reaction. J Clin Microbiol 1990;28:2187-2190.
10. Crompton CH, Cheung RK, Donjon C, et al. Epstein-Barr virus surveillance after renal transplantation. Transplantation 1994;57:1182-1189.
11. Martinez OM, Villanueva JC, Lawrence-Miyasaki L, Quinn MB, Cox K, Krams SM. Viral and immunologic aspects of Epstein-Barr virus infection in pediatric liver transplant recipients. Transplantation 1995;59:519-524.
12. Savoie A, Perpete C, Carpentier L, Joncas J, Alfieri C. Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease. Blood 1994;83:2715-2722.
13. Rogers BB, Conlin C, Timmons CF, Dawson DB, Krisher K, Andrews WS. Epstein-Barr virus PCR correlated with viral histology and serology in pediatric liver transplant patients. Pediatr Pathol Lab Med 1997;17:391-400.
14. Bai X, Hosler G, Rogers BB, Dawson DB, Scheuermann RH. Quantitative PCR for human herpes virus diagnosis and measurement of Epstein-Barr virus burden in posttransplant lymphoproliferative disorder. Clin Chem 1997; 43:1843-1849.
15. Rowe DT, Qu L, Reyes J, Jabbour N, et al. Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders. J Clin Microbiol 1997;35:1612-1615.
16. Frizzera G, Hanto DW, Gajl-Peczalska KJ, et al. Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 1981;41:4262-4271.
17. Howard TK, Klintmalm GBG, Stone MJ, et al. Lymphoproliferative disorder masquerading as rejection in liver transplant recipients - an early aggressive tumor with atypical presentation. Transplantation 1992;53:1145-1147.