Shortcomings of the randomized controlled trial: A view from the boondocks

Journal of Evaluation in Clinical Practice

Volumn 4, Issue 4, 1998, Pages 283-286

  Herman, Joseph ^a,b  

^a Assia Community Health Center   (Israel)

^b NONE   (Israel)

Author keywords

Epidemiology; Evidence based medicine; Limitations; Randomized controlled trials; Science

Indexed keywords

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; EVIDENCE BASED MEDICINE; HUMAN; RANDOMIZED CONTROLLED TRIAL; STANDARD;

EVIDENCE-BASED MEDICINE; HUMANS; RANDOMIZED CONTROLLED TRIALS;

EID: 0032196007     PISSN: 13561294     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2753.1998.tb00087.x     Document Type: Article

References (13)

1. Brown G., Albers J.J., Fisher L.D., Schaefer S.M., Lin J.-T., Kaplan C., Zhao X.-Q., Bisson B.D., Fitzpatrick V.F. & Dodge H.T. (1990) Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. New England Journal of Medicine 323, 1289-1298.
2. Brown N., Young T., Gray D., Skene A.M. & Hampton J.R. (1997) British Medical Journal 315, 159-164.
3. Chalmers I. (1995) What do I want from health research and researchers when I am a patient? British Medical Journal 310, 315-318.
4. Charlton B.G. (1996a) Megatrials are based on a methodological mistake. British Journal of General Practice 46, 429-431.
5. Charlton B.G. (1996b) The future of clinical research: from megatrials towards methodological rigour and representative sampling. Journal of Evaluation in Clinical Practice 2, 159-169.
6. Coste J., Letrait M., Carel J.C., Tresca J.P., Chatelain P. & Rochiccioli P. (1997) Long term results of growth hormone treatment in France in children of short stature: population register based study. British Medical Journal 315, 708-713.
7. DeWood M.A., Spores J., Notske R., Mouser L.T., Burroughs R., Golden M.S. & Lang H.T. (1980) Prevalence of total coronary occlusion during the early hours of myocardial infarction. New England Journal of Medicine 303, 897-902.
8. Sackett D.L. (1994) The Cochrane Collaboration. ACP Journal Club 120 (Suppl. 3), A-11.
9. Sackett D.L., Haynes R.B., Guyatt G.H. & Tugwell P. (1991) Clinical Epidemiology: a Basic Science for Clinical Medicine, 2nd edn. Little, Brown and Company, Boston.
10. Shahar E. (1997) A Popperian perspective of the term 'evidence-based medicine'. Journal of Evaluation in Clinical Practice 3, 109-116.
11. Sleigh J.W. (1997) Logical limits of randomized controlled trials. Journal of Evaluation in Clinical Practice 3, 145-148.
12. The TIMI Study Group (1989) Comparison of invasive and conservative strategies after treatment with intravenous plasminogen activator in acute myocardial infarction. New England Journal of Medicine 320, 618-627.
13. The University Group Diabetes Program (1970) Study of effects of hypoglycemic agents on vascular complications in patients with adult onset diabetes. Diabetes 19 (Suppl. 2), 787-830.