Characterization of human γ4 switch region polymorphisms suggests a meiotic recombinational hot spot within the Ig locus: Influence of S region length on IgG4 production

Journal of Immunology

Volumn 161, Issue 7, 1998, Pages 3520-3526

  Pan, Qiang ^a   Rabbani, Hodjattallah ^a   Hammarström, Lennart ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CROSSING OVER; GENE DELETION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MEIOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0032193814     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Hofker, M. H., M. A. Walter, and D. W. Cox. 1989. Complete physical map of the human immunoglobulin heavy chain constant region gene complex. Proc. Natl. Acad. Sci. USA 86:5567.
2. Lefranc, M. P., G. Lefranc, and T. H. Rabbitts. 1982. Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals. Nature 300:760.
3. Flanagan, J. G., and T. H. Rabbitts. 1982. Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and a genes. Nature 300:709.
4. Rabbani, H., Q. Pan, N. Kondo, C. I. E. Smith, and L. Hammarström. 1996. Duplications and deletions of the human IGHC locus: evolutionary implications. Immunogenetics 45:136.