The pathogenesis of chronic hepatitis B virus infection

Bulletin de l'Institut Pasteur

Volumn 96, Issue 4, 1998, Pages 227-236

  Feitelson, M A ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Chronic infection; HBV; Pathogenesis; Type B hepatitis; Variations

Indexed keywords

CHRONIC LIVER DISEASE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNE MEDIATED INJURY; LIVER CELL CARCINOMA; LIVER CELL DAMAGE; LIVER CIRRHOSIS; NONHUMAN; REVIEW; VIRUS CARRIER; VIRUS PATHOGENESIS;

EID: 0032193350     PISSN: 00202452     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-2452(99)80003-7     Document Type: Note

References (59)

1. [1] Feitelson, M.A. (1989), Hepatitis B virus gene products as immunological targets in chronic infection. Mol. Biol Med., 6, 367-393.
2. [2] Hoofnagle, J.H., Shafritz, D.A. & Popper, H. (1987), Chronic type B hepatitis and the "healthy" HBsAg carrier state. Hepatology, 7, 758-763.
3. [3] Dudley, F.J., Fox, R.A. & Sherlock, S. (1972), Cellular immunity and hepatitis-associated Australia antigen liver disease. Lancet, i, 723-726.
4. [4] Dunsford, H.A., Sell, S. & Chisari, F.V. (1990), Hepatocarcinogenesis due to chronic liver cell injury in HBV transgenic mice. Cancer Res., 50, 3400-3407.
5. [5] Chisari, F.V., Klopchin, K., Moriyama, T., Pasquinelli, C., Dunsford, H.A., Sell, S., Pinkert, C.A., Brinster, R.L. & Palmiter, R.D. (1989), Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell, 59, 1145-1156.
6. [6] Feitelson, M.A. (1994), Biology of hepatitis B variants. Lab. Invest., 71, 324-349.
7. [7] Tsai, S.-L., Liaw, Y.-F., Yeh, C.-T., Chu, C.M. & Kuo, G.C. (1995), Cellular immune responses in patients with dual infection of hepatitis B and C viruses: Dominant role of hepatitis C virus. Hepatology, 21, 908-912.
8. [8] Colombo, M., Cambieri, R., Rumi, M.G., Ronchi, G., Del Ninno, E. & De Franchis, R. (1983), Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis. Gastroenterology, 85, 235-239.
9. [9] Gilles, P.H., Guerrette, D.L., Ulevitch, R.J., Schreiber, R.D. & Chisari, F.V. (1992), Hepatitis B surface antigen retention sensitizes the hepatocyte to injury by physiologic concentrations of gamma interferon. Hepatology, 16, 655-663.
10. [10] Czaja, A.J., Carpenter, H.A., Santrach, P.J. & Moore, S.B. (1995), Immunologic features and HLA associations in chronic viral hepatitis. Gastroenterology, 108, 157-164.
11. [11] Hoofnagle, J.H., Davis, G.L., Pappas, C., Hanson, R.G., Peters, M., Avigan, M.I., Waggoner, J.G., Jones, E.A. & Seeff, L.B. (1986), A short course of prednisolone in chronic type B hepatitis. Ann. Intern, Med., 104, 12-17.
12. [12] Lampertico, P., Malter, J.S. & Gerber, M.A. (1991), Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics. Hepatology, 13, 422-426.
13. [13] Farza, H., Hadchouel, M., Scotto, J., Tiollais, P., Babinet, C. & Pourcel, C. (1988), Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J. Virol., 62, 4144-4152.
14. [14] Moriyama, T., Guihlot, S., Klopchin, K., Moss, B., Pinkert, C.A., Palmiter, R.D., Brinster, R.L., Kanagawa, O. & Chisari, F.V. (1990), Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science, 248, 361-364.
15. [15] Kim, C.M., Koike, K., Saito, I., Miyamura, T. & Jay, G. (1991), HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature, 351, 317-320.
16. [16] Ueda, H., Ullrich, S.J., Gangemi, J.D., Kappel, C.A., Ngo, L., Feitelson, M.A. & Jay G. (1995), Functional inactivation but not structural mutation of p53 causes liver cancer. Nature Genet., 9, 41-47.
17. [17] Takahasi, H., Fujimoto, J., Hanada, S. & Isselbacher, K.J. (1995), Acute hepatitis in rats expressing human hepatitis B virus transgenes. Proc. Natl. Acad. Sci. USA, 92, 1470-1474.
18. [18] Feitelson, M.A., DeTolla, L. & Zhou, X.-D. (1988), A chronic carrier-like state is established in nude mice injected with cloned hepatitis B virus DNA. J. Virol., 62, 1408-1415.
19. [19] Popper, H., Roth, L., Purcell, R.H., Tennant, B.C. & Gerin, J.L. (1987), Hepatocarcinogenicity of the woodchuck hepatitis virus. Proc. Natl. Acad. Sci. USA, 84, 866-870.
20. [20] Marion, P.L., Davelaar, M.J.V., Knight, S.S., Salazar, F.H., Garcia, G., Popper, H. & Robinson, W.S. (1986), Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus. Proc. Natl. Acad. Sci. USA, 83, 4543-4546.
21. [21] Cullen, J.M., Marion, P.L., Sherman, G.J., Hong, X. & Newbold, J.E. (1990), Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free Pekin ducks. Cancer Res., 50, 4072-4080.
22. [22] Colucci, G., Colombo, M., Del Nino, E. & Paronetto, F. (1983), In situ characterization by monoclonal antibodies of the mononuclear cell infiltrate in chronic active hepatitis. Gastroenterology, 85, 1138-1145.
23. [23] Blum, H.E., Haase, A.T. & Vyas, G.N. (1984), Molecular pathogenesis of hepatitis B virus infection: simultaneous detection of viral DNA and antigens in paraffin-embedded liver sections. Lancet, ii; 771-775.
24. [24] Fukusato, F., Gerber, M.A., Thung, S.N., Ferrone, S. & Schaffner, F. (1986), Expression of HLA class I antigens on hepatocytes in liver disease. Am. J. Pathol, 123, 264-270.
25. [25] Wang, W., London, W.T. & Feitelson, M.A. (1991), Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer. Cancer Res., 51, 4971-4977.
26. [26] Thursz, M.R., Kwiatkowski, D., Allsopp, C.E.M., Greenwood, B.M., Thomas, H.C. & Hill, A.V. (1995), Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N. Engl. J. Med., 332, 1065-1069.
27. [27] Milich, D.R. & Chisari, F.V. (1982), Genetic regulation of the immune response to HBsAg. I. H-2 restriction of the murine humoral immune response to the a and d determinants of HBsAg. J. Immunol., 129, 320-325.
28. [28] Milich, D.R., Peterson, D.L., Schodel, F., Jones, J.E. & Hughes, J.L. (1995), Preferential recognition of hepatitis B nucleocapsid antigens by Th1 or Th2 cells is epitope and major histocompatibility complex dependent. J. Virol., 69, 2776-2785.
29. [29] Franco, A., Barnaba, V., Natali, P., Balsano, C., Musca, A. & Balsano, F. (1988), Expression of class I and class II major histocompatibility complex antigens on human hepatocytes. Hepatology, 8, 449-454.
30. [30] van den Oord, J., de Vos, R. & Desmet, V. (1986), In situ distribution of MHC products and viral antigens in chronic HBV infection: Evidence that HBc-containing hepatocytes express HLA-DR antigens. Hepatology, 6, 981-989.
31. [31] Ferrari, C., Penna, A., Bertoletti, A., Valli, A., Antoni, A.D., Giuberti, T., Cavalli, A., Petit, M.A. & Fiaccadori, F. (1990), Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J. Immunol., 145, 3442-3449.
32. [32] Maruyama, T., Schodel, F., Lino, S., Koike, K., Yasuda, K., Peterson, D. & Milich, D.R. (1994), Distinguishing between acute and symptomatic chronic hepatitis B virus infection. Gastroenterology, 106, 1006-1015.
33. [33] Jung, M-C, Diepolder, H.M. & Pape, G.R. (1994), T cell recognition of hepatitis B and C viral antigens. Eur. J. Clin. Invest., 24, 641-650.
34. [34] Toyonaga, T., Hino, O., Sugai, S., Wakasugi, S., Abe, K., Shichiri, M. & Yamamura, K. (1994), Chronic active hepatitis in transgentc mice expressing interferon-γ in the liver. Proc. Natl. Acad. Sci. USA, 91, 614-618.
35. [35] Gilles, P.N., Fey, G. & Chisari, F.V. (1992), TNFα negatively regulates HBV gene expression in transgenic mice. J. Virol., 66, 3955-3960.
36. [36] Guilhot, S., Guidotti, L.G. & Chisari, F.V. (1993), Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a posttranscriptional mechanism. J. Virol., 67, 7444-7449.
37. [37] Chung, R.T. (1994), Just say "NO" to viral hepatitis ? Hepatology, 19, 790-792.
38. [38] Gonzalez-Amaro, R., Garcia-Monzon, C. & Garcia-Buey, L. (1994), Induction of tumor necrosis factor a production by human hepatocytes in chronic viral hepatitis. J. Exp. Med., 179, 841-845.
39. [39] Yoakum, G.H., Korba, B.E., Lechner, J.F., Tokiwa, T., Gazdar, A.F., Seeley, T., Siegel, M., Leeman, L., Autrup, H. & Harris, C.C. (1983), High-frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells. Science, 222, 385-389.
40. [40] Kim, H., Lee, H. & Yun, Y. (1998), X-gene product of hepatitis B virus induces apoptosis in liver cells. J. Biol. Chem., 273, 381-385.
41. [41] Su, F. & Schneider, R.J. (1997), Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc. Natl. Acad. Sci. USA, 94, 8744-8749.
42. [42] Kakumu, S., Ishikawa, T., Wakita, T., Yoshioka, K., Takayanagi, M., Tahara, H. & Kusakage, A. (1994), Interferon-γ production specific for HBV antigens by intrahepatic T lymphocytes in patients with acute and chronic hepatitis B. Am. J. Gastroenterol., 89, 92-96.
43. [43] Poitrine, A., Chousterman, S., Chousterman, M., Naveau, S., Thang, M.N. & Chaput, J.C. (1985), Lack of in vivo activation of the interferon system in HBsAg-positive chronic active hepatitis. Hepatology, 5, 171-174.
44. [44] Perrillo, R.P. (1993), Antiviral therapy of chronic hepatitis B: past, present and future. J. Hepatol., 17, S56-S63.
45. [45] Meuer, S.C. & Moebius, U. (1994), Immune mechanisms underlying HBV persistence. Sem. Virol., 5, 289-295.
46. [46] Autschbach, F., Meuer, S.C., Moebius, U., Manns, M., Hess, G., Meyer zum Buschenfelde, K.H., Thoenes, W. & Dienes, H.P. (1991), Hepatocellular expression of lymphocyte function-association antigen 3 in chronic hepatitis. Hepatology, 14, 223-230.
47. [47] Beutler, B. & Cerami, A. (1988), The common mediator of shock, cachexia, and tumour necrosis. Adv. Immunol., 42, 213-231.
48. [48] Hussain, M.J., Lau, J.Y.N., Williams, R. & Vergani, D. (1994), Hepatic expression of TNFα in chronic HBV infection. J. Clin. Pathol., 47, 1112-1115.
49. [49] Jilbert, A.R., Burell, C.J., Gowans, E.J., Hertzog, P.J., Linnane, A.W. & Marmion, B.P. (1986), Cellular localization of α-interferon in HBV-infected liver tissue. Hepatology, 6, 957-961.
50. [50] Van Hecke, E.V., Paradijs, J., Molitor, C., Bastin, C., Pala, P., Slaoui, M. & Leroux-Roels, G. (1994), Hepatitis B virus-specific cytotoxic T lymphocyte responses in patients with acute and chronic hepatitis B virus infection. J. Hepatol., 20, 514-523.
51. [51] Nayersina, R., Fowler, P., Guilhot, S., Missale, G., Cerny, A., Schlicht, H.J., Vitiello, A., Chesnut, R., Person, J.L. & Redeker, A.G. (1993), HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J. Immunol., 150, 4659-4671.
52. [52] Barnaba, V., Franco, A., Alberti, A., Benvenuto, R. & Balsano, F. (1990), Selective killing of HBsAg-specific B cells by class I restricted, exogenous antigen-specific T lymphocytes. Nature, 345, 258-260.
53. [53] Milich, D.R., McLachlan, A., Moriarty, A. & Thornton, G.B. (1987), The immune response to the hepatitis B core antigen (HBcAg) : localization of T cell recognition sites within HBcAg/HBeAg. J. Immunol., 139, 1223-1231.
54. [54] Milich, D.R., Jones, J.E., Hughes, J.L., Price, J., Raney, A.K. & McLachlan, A. (1990), Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero ? Proc. Natl. Acad. Sci. USA, 87, 6599-6603.
55. [55] Feitelson, M.A. & Duan, X.-L. (1997), Hepatitis B virus x antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. Am. J. Pathol., 150, 1141-1157.
56. [56] Nakatake, H., Chisaka, O., Yamamoto, S., Matsubara, K. & Koshy, R. (1993), Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication. Virology, 195, 305-314.
57. [57] Chen, H.-S., Kaneko, S. & Girones, R. (1993), The woodchuck hepatitis virus X gene is important for establishments of virus infection in woodchucks. J. Virol., 67, 1218-1226.
58. [58] Feitelson, M.A., Millman, I., Duncan, G.D. & Blumberg, B.S. (1988), Presence of antibodies to the polymerase gene product(s) of HBV and WHV in natural and experimental infections. J. Med. Virol., 24, 121-136.
59. [59] Rehermann, B., Fowler, R., Sidney, J., Person, J., Redeker, A., Brown, M., Moss, B., Sette, A. & Chisari, F.V. (1995), The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J. Exp. Med., 181, 1047-1058.