Lck-Independent Inhibition of T Cell Antigen Response by the HIV gp120

Journal of Immunology

Volumn 161, Issue 7 A, 1998, Pages 3551-3556

  Gratton, Sophie ^a,b,e   Julius, Michael ^c   Sékaly, Rafick Pierre ^a,d  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 120; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN TYROSINE KINASE; T LYMPHOCYTE ANTIGEN;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CELL CYCLE G0 PHASE; GENETIC TRANSFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0032193229     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Janeway, C. A. Jr. 1992. The T cell receptor as a multicomponent signaling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Iminunol. 10:645.
2. Rudd, C. E., J. M. Trevillyan, J. V. Dasgupta, L. L. Wong, and S. F. Schlossman. 1988. The CD4 antigen is complexed in detergent lysates to protein tyrosine kinase (pp58) from human T lymphocytes. Proc. Natl. Acad. Sci. USA 85:5190.
3. lck. Cell 55:301.
4. lck with CD4 in antigen-specific signal transduction in T cells. Cell 64:511.
5. lck, through its unique amino-terminal domain. Cell 59:627.
6. lck tyrosine protein kinase. Mol. Cell. Biol. 10:1813.
7. lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60:755.
8. Luo, K., and B. M. Sefton. 1990. Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol Cell. Biol. 10:5305.
9. lck. Nature 338:257.
10. lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol. Cell. Biol. 12:4521.
11. Strauss, B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585.
12. Hall, C. G., J. Sancho, and C. Terhorst. 1993. Reconstitution of T cell receptor z-mediated calcium mobilization in non lymphoid cells. Science 261:915.
13. Iwashima, M., B. A. Irving, N. S. van Oers, A. C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136.
14. lck with CD4 inhibits the induction of growth through the αβ T-cell receptor. Nature 358:328.
15. lck in antibody-triggered T cell signal transduction. J. Biol. Chem. 269:24095.
16. Banda, N. K., J. Bernier, D. K. Kurahara, R. Kurrle, W. Haigwood, R.-P. Sékaly, and T. Finkel. 1992. Cross-linking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp. Med. 176:1099.
17. Newell, M. K., L. J. Haughn, C. R. Maroun, and M. H. Julius. 1990. Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature 347:286.
18. Rosoff, P. M., S. J. Burakoff, and J. L. Greenstein. 1987. The role of L3T4 molecule in mitogen and antigen activated signal transduction. Cell 49:845.
19. Tite, J. P., A. Sloan, and C. A. Janeway. 1986. The role of L3T4 in T-cell activation: L3T4 may be both an Ia binding protean and receptor that transduces a negative signal. J. Mol. Cell. Immunol. 2:179.
20. lck activation and TCR desensitization independent of TCR tyrosine phosphorylation. J. Immunol 153:2905.
21. lck with CD4 in human T lymphocytes. J. Biol. Chem. 266:1.
22. Kornfeld, H., W. W. Cruikshank, S. W. Pyle, J. S. Berman, and D. M. Center. 1988. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature 335:445.
23. lck autophosphorylation and kinase activity. Int. Immunol. 4:295.
24. lck together with impairment of T cell activation. J. Immunol. 149:285.
25. Chimurle, N., V. S. Kalyanaraman, N. Oyaizu, H. B. Slade, and S. Pahwa. 1990. Inhibition of functional properties of tetanus antigen-specific T cell clones by envelope glycoprotein gp120 of human immunodeficiency virus. Blood 75:152.
26. Mann, D. L., F. Lasane, M. Popovic, L. O. Arthur, W. G. Robey, W. A. Blattner, and M. J. Newman. 1987. HTLV-III large envelope protein (gp120) suppresses PHA-induced lymphocyte blastogenesis. J. Immunol. 138:2640.
27. Mittler, R. S., and M. K. Hoffman. 1989. Synergism between HIV gp120 and gp120-specific antibody in blocking human T cell activation. Science 245:1380.
28. + T lymphocytes by inhibiting interleukin-2 mRNA. Proc. Natl. Acad. Sci. USA 87:2379.
29. lck association. J. Exp. Med. 179:1973.
30. Vignali, D. A., R. T. Carson, B. Chang, B. G. Mittler, and J. L. Strominger. 1996. The two membrane proximal domains of CD4 interact with the T cell receptor. J. Exp. Med. 183:2097.
31. Vignali, D. A., and J. L. Strominger. 1994. Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor. J. Exp. Med. 179:1945.
32. Gratton, S., X.-J. Yao, S. Venkatesan, E. Cohen, and R. P. Sékaly. 1996. Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by PMA and Nef. J. Immunol. 157:3305.
33. Shin, J., C. Doyle, Z. Yang, D. Kappes, and J. Strominger. 1990. Structural features of the cytoplasmic region of CD4 required for internalization. EMBO J. 9:425.
34. Oh, A.-Y., W. W. Cruikshank, J. Raina, G. C. Blanchard, W. H. Adler, J. Waker, and H. Kornfeld. 1992. Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients. J. Acquired Immune Defic. Syndr. 5:2251.
35. Lane, H. C., J. M. Depper, G. Whalen, A. Waldman, and A. S. Fauci. 1985. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 313:79.
36. Gupta, S., and B. Safai. 1983. Deficient autologous mixed lymphocyte reaction in Kaposi's sarcoma associated with deficiency of leu3 positive responder T cells. J. Clin. Invest. 71:296.
37. Smith, K. A. 1987. Dissection of the molecular events occurring during T cell cycle progression. Adv. Exp. Med. Biol. 213:125.
38. Boulikas, T. 1995. Phosphorylation of transcription factors and control of the cell cycle. Crit. Rev. Eukaryotic Gene Expression. 5:1.
39. Siekierka, J. J. 1994. Probing T cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. Immunol. Res. 13:110.
40. Baldari, C. T., E. Milia, M. M. DiSomma, F. Baldoni, S. Valitutti, and J. L. Telford. 1995. Distinct signaling properties identify functionally different CD4 epitopes. Eur. J. Immunol. 25:1843.
41. + T lymphocytes. Eur. J. Immunol. 27:397.
42. lck by gp120, a model for TCR desensitization. J. Immunol. 158:2017.
43. Sakihama, T., A. Smolyar, and E. L. Reinherz. 1995. Oligomerization of CD4 is required for stable binding to class II MHC proteins but not for interaction with HIV gp120. Proc. Natl. Acad. Sci. USA 92:6444.
44. Dianzani, U., U. Redoglia, F. Malavasi, M. Bragardo, A. Pileri, C. A. Janeway, and K. Bottomly. 1992. Isoform-specific associations of CD45 with accessory molecules in human T lymphocytes. Eur. J. Immunol. 22:365.
45. Kupfer, A., S. J. Singer, C. J. Janeway, and S. L. Swain. 1987. Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc. Natl. Acad. Sci. USA 84:5888.
46. Mittler, R. S., B. M. Rankin, and P. A. Kiener. 1991. Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells. J. Immunol. 147:3434.
47. Weyand, C. M., J. Goronzy, and G. Fathman. 1987. Modulation of CD4 by antigenic activation. J. Immunol 138:1351.
48. + T cells. Cell. Immunol. 175:1.
49. + primary T cells. Eur. J. Immunol. 24:967.
50. Maroun, C. R., and M. Julius. 1994. Distinct roles for CD4 and CD8 as co-receptors in T cell receptor signaling. Eur. J. Immunol. 24:959.
51. Novak, T. J., D. Farber, D. Leitenberg, S. C. Hong, P. Johnson, and K. Bottomly. 1994. Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. Immunity 1:109.
52. Leitenberg, D., T. J. Novak, D. Farber, B. R. Smith, and K. Bottomly. 1996. The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen specific stimulation J. Exp. Med. 183:249.