Progesterone 6-hydroxylation is catalysed by cytochrome P-450 in the moderate thermophile Bacillus Thermoglucosidasius strain 12060

Journal of Steroid Biochemistry and Molecular Biology

Volumn 67, Issue 2, 1998, Pages 163-169

  Sideso, Odafe ^a   Williams, Ralph A D ^a   Welch, Simon G ^a   Smith, Kelvin E ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; PROGESTERONE;

ARTICLE; BACILLUS; BACTERIAL METABOLISM; CATALYSIS; HORMONE DETERMINATION; HORMONE METABOLISM; HYDROXYLATION; NONHUMAN; THERMOPHILIC BACTERIUM;

BACILLUS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; PROGESTERONE;

EID: 0032191744     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(98)00101-0     Document Type: Article

References (12)

1. Peterson D.H., Murray H.C. Microbiological oxygenation of steroids at carbon 11. J. Am. Chem. Soc. 74:1952;11871-11872.
2. J.K. Kristjansson, in: Thermophilic Bacteria. CRC Press, Boca Raton, 1992.
3. 1H NMR spectra of the steroid hormones, their hydroxylated derivatives and related compounds J. Chem. Soc. Perkin Trans. 2:1990;1567-1594.
4. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
5. Rabilloud T., Carpenter G., Tarroux P. Mechanism of silver staining in polyacrylamide gels. Electrophoresis. 9:1988;288-291.
6. Wilson J.E., Ober R.E., Vesting C.S. Hydroxylation of deoxycorticosterone by Bacillus cereus, strain T. Arch. Biochem. Biophys. 114:1966;166-177.
7. meg. J. Biol. Chem. 254:1979;5264-5271.
8. Joska J., Prochazka Z., Fajkos J., Sorm F. On steroids, CLII. Microbiological oxygenation of B-norsteroids. Coll. Czech. Chem. Commun. 38:1973;1398-1405.
9. Schubert K., Groh H., Horhold C. Abbau von Steroiden, XIII. Hydroxylierung von 17α-Methylostradiol in 2-, 4- und 6α-Stellungdurch Aspergillus flavus. J. Steroid Biochem. 2:1971;281-288.
10. A.M. Bell, P.C. Cherry, I.M. Clark, W.A. Denny, E.R.H. Jones, G.D. Meakins, P.D. Woodgate, Microbiological hydroxylation of steroids, Part IV. The pattern of dihydroxylation of mono-oxygenated 5α-androstanes with cultures of the fungus Calonectria decora, J. Chem. Soc. Perkin I (1972) 2081-2095.
11. A.M. Bell, D. Boul, E.R.H. Jones, G.D. Meakins, J.O. Miners, A.L. Wilkins, Microbiological hydroxylation of steroids, Part XVIII. Introduction of 16α-, 9α- and 3α-hydroxy-groups to the dioxygenated 5α-androstanes by the fungus Diaporthe celastrina, J. Chem. Soc. Perkin I (1975) 1364-1366.
12. 13C nuclear magnetic resonance spectra of some B-norsteroids Can. J. Chem. 59:1981;1651-1655.