A short and efficient total synthesis of the cytotoxic (+)-goniodiol and (+)-9-deoxygoniopypyrone

Tetrahedron Letters

Volumn 39, Issue 40, 1998, Pages 7299-7300

  Surivet, Jean Philippe ^a   Vatèle, Jean Michel ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

Antitumor compounds; Coupling reactions; Lactones; Sulfones

Indexed keywords

9 DEOXYGONIOPYPYRONE; ANTINEOPLASTIC AGENT; GONIODIOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOPATHOGENIC EFFECT; DRUG CONFORMATION; DRUG EFFECT; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 0032191535     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01562-7     Document Type: Article

References (18)

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16. 8. Analytical and spectral data were obtained for all new compounds and are consistent with the structure assigned.
17. 9. Synthetic (+)-goniodiol and (+)-9-deoxygoniopypyrone display physical and spectroscopic data in agreement with those of natural compounds (ref. 3).
18. 10. Indeed, in the presence of HMPA, beside 5b obtained in 50-77% yield was isolated compound 9 in 20-30% yield. (equation presented)