Vasodilator response to exogenous adrenocorticotropic hormone in fetal adrenal cortex precedes increased steroidogenesis in sheep at 105-112 days gestation

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 81, Issue 1, 1998, Pages 87-94

  Carter, Anthony M ^a   Challis, John R G ^b   Svendsen, Per ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b NONE

Author keywords

Adrenal cortical blood flow; Corticosteroids; Fetal circulation; Radiolabeled microspheres

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE; MICROSPHERE; TETRACOSACTIDE;

ADRENAL CORTEX; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; FETUS; GESTATIONAL AGE; HYDROCORTISONE BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SHEEP; STEROIDOGENESIS; VASODILATATION;

EID: 0032190097     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-2115(98)00137-7     Document Type: Article

References (31)

1. [1] Carter AM, Richardson BS, Homan J, Towstoless M, Challis JRG. Regional adrenal blood flow responses to adrenocorticotropic hormone in fetal sheep. Am J Physiol 1993;264(Endocrinol Metab 27):E264-9.
2. [2] Carter AM, Challis JRG, Svendsen P. Regional adrenal blood flow responses to adrenocorticotropic hormone after chronic embolization of the fetal placental circulation in sheep. J Endocrinol 1996;148:517-22.
3. [3] Iwamoto HS. Cardiovascular effects of acute fetal hypoxia and asphyxia. In: Hanson MA, Spencer JAD, Rodeck CH, editors. Fetus and neonate: physiology and clinical applications. Vol. 1, The circulation. Cambridge: Cambridge University Press, 1993; 197-214.
4. [4] Carter AM, Homan J, Fraser M, Richardson BS, Challis JRG. Inhibition of ACTH secretion blocks the hypoxia-induced increase of adrenal cortical blood flow in fetal sheep. Am J Physiol 1995;269(Endocrinol Metab 32):E598-604.
5. [5] Breslow MJ. Regulation of adrenal medullary and cortical blood flow. Am J Physiol 1992;262(Heart Circ Physiol 31):H1317-30.
6. [6] Buchwalder LF, Lin M, McDonald TJ, Nathanielsz PW. Fetal sheep adrenal blood flow responses to hypoxemia after splanchnicotomy using fluorescent microspheres. J Appl Physiol 1998;84:82-9.
7. [7] Wintour EM, Brown EH, Denton DA, Hardy KJ, Mcdougall JG, Oddie CJ, Whipp GT. The ontogeny and regulation of corticosteroid secretion by the ovine foetal adrenal. Acta Endocrinol 1975;79:301-16.
8. [8] Glickman JA, Challis JRG. The changing response pattern of sheep fetal adrenal cells throughout the course of gestation. Endocrinology 1980;106:1371-6.
9. [9] Tangalakis K, Coghlan JP, Crawford R, Hammond VE, Wintour EM. Steroid hydroxylase gene expression in the ovine fetal adrenal gland following ACTH infusion. Acta Endocrinol 1990;123:371-7.
10. [10] Challis JRG, Patrick JE, Cross J, Workewych J, Manchester E, Power S. Short-term fluctuations in the concentration of cortisol and progesterone in fetal plasma, maternal plasma, amniotic and allantoic fluids from sheep during late pregnancy. Can J Physiol Pharmacol 1981;59:261-7.
11. [11] Norman LJ, Lye SJ, Wlodek ME, Challis JRG. Changes in pituitary responses to synthetic ovine corticotrophin releasing factor in fetal sheep. Can J Physiol Pharmacol 1985;63:1398-403.
12. [12] Tangalakis K, Roberts FE, Wintour EM. The time-course of ACTH stimulation of cortisol synthesis by the immature ovine foetal adrenal gland. J Steroid Biochem Mol Biol 1992;42:527-32.
13. [13] Akagi K, Challis JRG. Hormonal and biophysical responses to acute hypoxemia in fetal sheep at 0.7-0.8 gestation. Can J Physiol Pharmacol 1990;68:1527-32.
14. [14] Gleason CA, Hamm C, Jones MD. Effect of acute hypoxemia on brain blood flow and oxygen metabolism in immature fetal sheep. Am J Physiol 1990;258(Heart Circ Physiol 27):H1064-9.
15. [15] Iwamoto HS, Kaufman T, Keil LC, Rudolph AM. Responses to acute hypoxemia in fetal sheep at 0.6-0.7 gestation. Am J Physiol 1989;256(Heart Circ Physiol 25):H613-20.
16. [16] Faraci FM, Chilian WM, Williams JK, Heistad DD. Effects of reflex stimuli on blood flow to the adrenal medulla. Am J Physiol 1989;257(Heart Circ Physiol 26):H590-6.
17. [17] Boshier DP, Holloway H. Morphometric analyses of adrenal gland growth in fetal and neonatal sheep. I. The adrenal cortex. J Anat Lond 1989;167:1-14.
18. [18] Tangalakis K, Lumbers ER, Moritz KM, Towstoless MK, Wintour EM. Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Exp Physiol 1992;77:709-17.
19. [19] Heymann MA, Payne BD, Hoffman JIE, Rudolph AM. Blood flow measurements with radionuclide-labeled particles. Progr Cardiovasc Dis 1977;20:55-78.
20. [20] Buckberg GD, Luck JC, Payne DB, Hoffman JIE, Archie JP, Fixler DE. Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 1971;31:598-604.
21. [21] Dole WP, Jackson DI, Rosenblatt JI, Thompson WI. Relative error and variability in blood flow measurements with radiolabeled microspheres. Am J Physiol 1982;243(Heart Circ Physiol 12):H371-8.
22. 4 isomerase, tyrosine hydroxylase and phenylethanolamine N-methyl transferase in the adrenal gland of fetal sheep throughout gestation and in neonates. J Reprod Fert 1992;96:127-34.
23. [23] Comline RS, Silver M. The release of adrenaline and noradrenaline from the adrenal glands of the foetal sheep. J Physiol Lond 1961;156:424-44.
24. [24] Clifton Vl, Read MA, Boura AL, Robinson PJ, Smith R. Adrenocorticotropin causes vasodilatation in the human fetal-placental circulation. J Clin Endocrinol Metab 1996;81:1406-10.
25. [25] Slotten P, Phernetton TM, Rankin JHG. Relationship between fetal electrocorticographic changes and umbilical blood flow in the near-term sheep fetus. J Dev Physiol Oxf 1989;11:19-23.
26. [26] Cone RD, Mountjoy KG, Robbins LS, Nadeau JH, Johnson KR, Roselli-Rehfuss L, Mortrud MT. Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann NY Acad Sci 1993;680:342-63.
27. [27] Mesiano S, Fujimoto VY, Nelson LR, Lee JY, Voytek CC, Jaffe RB. Localization and regulation of corticotropin receptor expression in the midgestation human fetal adrenal cortex: implications for in utero homeostasis. J Clin Endocrinol Metab 1996;81:340-5.
28. [28] Breslow MJ, Tobin JR, Bredt DS, Ferris CD, Snyder SN, Traystman RJ. Nitric oxide as a regulator of adrenal blood flow. Am J Physiol 1993;264(Heart Circ Physiol 33):H464-9.
29. [29] Sakima NT, Breslow MJ, Raff H, Traystman RJ. Lack of coupling between adrenal cortical metabolic activity and blood flow in anesthetized dogs. Am J Physiol 1991;261(Heart Circ Metab 30):H410-5.
30. [30] L'Age M, Gonzalez-Luque A, Yates FE. Adrenal blood flow dependence of Cortisol secretion rate in unanesthetized dogs. Am J Physiol 1970;219:281-7.
31. [31] Jones CT, Edwards AV, Bloom SR. The effect of changes in adrenal blood flow on adrenal cortical responses to adrenocorticotrophin in conscious calves. J Physiol Lond 1990;429:377-86.