In Vivo and in Vitro Photodynamic Studies with Benzochlorin Iminium Salts Delivered by a Lipid Emulsion

Photochemistry and Photobiology

Volumn 68, Issue 4, 1998, Pages 561-568

  Garbo, G M ^a,d   Fingar, V H ^a   Wieman, T J ^a   Noakes III, E B ^a   Haydon, P S ^a   Cerrito, P B ^b   Kessel, D H ^c   Morgan, A R ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEUTEROPORPHYRIN DERIVATIVE; DRUG CARRIER; IMINE; PHOTOSENSITIZING AGENT;

ADENOCARCINOMA; ANIMAL; ARTICLE; C3H MOUSE; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; EMULSION; EXPERIMENTAL NEOPLASM; FEMALE; FIBROSARCOMA; LEUKEMIA L 1210; LIGHT; MOUSE; PHOTOCHEMOTHERAPY; RADIATION EXPOSURE; RADIATION INJURY;

ADENOCARCINOMA; ANIMALS; CELL SURVIVAL; DEUTEROPORPHYRINS; DRUG CARRIERS; EMULSIONS; FEMALE; FIBROSARCOMA; IMINES; LEUKEMIA L1210; LIGHT; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C3H; NEOPLASMS, RADIATION-INDUCED; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 0032185929     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1998.tb02514.x     Document Type: Article

References (31)

1. Fisher, A. M. R., A. L. Murphree and C. J. Gomer (1995) Clinical and preclinical photodynamic therapy. Lasers Surg. Med. 17, 2-33.
2. Luo, Y., C. K. Chang and D. Kessel (1996) Rapid initiation of apoptosis by photodynamic therapy. Photochem. Photobiol. 63, 528-534.
3. Levy, J. (1995) The preclinical and clinical development of Photofrin® and benzoporphyrin derivative: a reflection on opportunities and changes. (ESP Newsletter). J. Photochem. Photobiol. B Biol. 30, 79-82.
4. FDA Oncologic Drugs Advisory Committee meeting, 18 September 1997.
5. QLT Phototherapeutics Inc. Third Quarter Report 97, 30 September 1997.
6. Levy, J., A. Chan and H. A. Strong (1996) Clinical status of benzoporphyrin derivative. In Proceedings of Photochemotherapy: Photodynamic Therapy and Other Modalities, Vol. 2625 (Edited by B. Ehrenberg, G. Jori and J. Moan), pp. 86-95. SPIE, Bellingam, WA.
7. Razum, N. J., A. B. Snyder and D. R. Doiron (1996) SnET2: clinical update. In Proceedings of Optical Methods for Tumor treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, Vol. 2675 (Edited by T. J. Dougherty), pp. 43-46. SPIE, Bellingam, WA.
8. Wieman, T. J., V. Fingar, S. Taber, M. Panjehpour, C. Julius, T. J. Panella, A. Yuen, S. Horning, K. Woodburn, J. Engel, M. F. Renschler and S. W. Young (1996) Phase I photodynamic therapy trial with lutetium texaphyrin (PCI-0123) in patients with metastatic cancer. Abstract presented at the 24th Annual Meeting of the American Society for Photobiology, Atlanta, GA, 15-20 June 1996.
9. Ris, H.-B., H. J. Altermatt, B. Nachbur, J. C. M. Stewart, Q. Wang, C. K. Lim, R. Bonnett and U. Althaus (1993) Effect of drug-light interval on photodynamic therapy with meta-tetrahydroxyphenylchlorin in malignant mesothelioma. Int. J. Cancer 53, 141-146.
10. Potter, R. H. and J. C. Kennedy (1996) Photodynamic therapy with 5-aminolevulinic acid: basic principles and applications. In Proceedings of Photochemotherapy: Photodynamic Therapy and Other Modalities, Vol. 2625 (Edited by B. Ehrenberg, G. Jori and J. Moan), pp. 2-11. SPIE, Bellingam, WA.
11. Selman, S. H., J. A. Hampton, A. R. Morgan, R. W. Keck, A. D. Balkany and D. Skalkos (1993) Copper benzochlorin, a novel photosensitizer for photodynamic therapy: effects on a transplantable urothelial tumor. Photochem. Photobiol. 57, 681-685.
12. Morgan, A. R. and S. Gupta (1994) Synthesis of benzochlorin iminium salts with improved photosensitizing properties. Tetrahedron Lett. 35, 5347-5352.
13. Skalkos, D., J. A. Hampton, R. W. Keck, M. Wagoner and S. H. Selman (1994) Iminium salt benzochlorins: structure-activity relationship studies. Photochem. Photobiol. 59, 175-181.
14. Garbo, G. M. (1996) Purpurins and benzochlorins as sensitizers for photodynamic therapy. J. Photochem. Photobiol. B Biol. 34, 109-116.
15. Hampton, J. A., D. Skalkos, P. M. Taylor and S. H. Selman (1993) Iminium salt of copper benzochlorin (CDS1), a novel photosensitizer for photodynamic therapy: mechanism of cell killing. Photochem. Photobiol. 58, 100-105.
16. Kessel, D., K. Woodburn and D. Skalkos (1994) Impaired accumulation of a cationic photosensitizing agent by a cell line exhibiting multidrug resistance. Photochem. Photobiol. 60, 61-63.
17. Hampton, J. A., D. Decker and D. Kessel (1994) Immunohistochemical demonstration of multidrug resistance in the FANFT-induced urothelial tumor: implications for CDS1 mediated photodamage. Photochem. Photobiol. 59S, 11S.
18. Woodcock, D. M., S. Jefferson, M. L. Linsemeyer et al. (1990) Reversal of the multidrug resistance phenotype with cremophor E1, a common vehicle for water-insoluble vitamins and drugs. Cancer Res. 50, 4199.
19. Woodcock, D. M., M. E. Linsenmeyer, G. Chojnoswki, A. B. Kriegler, V. Nink, L. K. Webster and W. H. Sawyer (1992) Reversal of multidrug resistance by surfactants. Br. J. Cancer 66, 62-68.
20. Schuurhuis, G. J., H. J. Broxterman, H. M. Pinedo et al. (1990) The polyoxyethylene castor oil cremophor E1 modifies multi-drug resistance. Br. J. Cancer 62, 591.
21. Friche, E., P. B. Jensen, M. Sehested, E. J. Demant and N. N. Nissen (1990) The solvents cremophor E1 and Tween 80 modulate daunorubicin resistance in multidrug resistance Ehrlich ascites tumor. Cancer Commun. 2, 279-303.
22. Kessel, D. (1993) Sites of photodamage by the iminium salt of a copper octaethylbenzochlorin. Photochem. Photobiol. 58, 623-626.
23. Ricchelle, M., Y. A. Carpentier and R. J. Deckelbaum (1994) Long- and medium-chain triacylglycerols in neutral lipid-exchange processes with human plasma low-density lipoproteins. Biochemistry 33, 4872-4878.
24. Mizushima, Y., Y. Shou, T. Kato, M. Fukushima and S. Kurozumi (1986) Use of lipid microspheres as a drug carrier for antitumour drugs. J. Pharm. Pharmacol. 38, 132-134.
25. Twentyman, P. R., J. M. Brown, J. W. Gray, A. J. Franko, M. A. Scoles and R. F. Kallaman (1980) A new mouse tumor model system (RIF-1) for comparison and end-point studies. JNCI 64, 595-604.
26. Corbett, T. H., F. A. Valeriote, L. Polin, C. Panchapor, S. Pugh, K. White, N. Lowichik, J. Knight, M. C. Bissery, A. Wozniak, P. LoRusso, L. Biernat, D. Polin, L. Knight, S. Biggar, D. Looney, L. Demichik, J. Jones, L. Jones, S. Blair, K. Palmer, S. Essenmacher, L. Lisow, K. C. Matter, P. F. Cavanaugh, J. B. Rake and L. Baker (1990) Discovery of solid tumor active agents using a soft-agar-colony formation disk-diffusion assay. In Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development (Edited by R. A. Valeriote, T. H. Corbett and L. H. Baker), pp. 35-87. Kluwer, Norwell, MA.
27. Graschew, G. And M. Shopova (1986) Hypoxia, misonidazole and hyperthermia in photodynamic treatment of tumours. Laser Med. Sci. 181-186.
28. Collins-Gold, L. C., R. T. Lyons and L. C. Bartholow (1990) Parental emulsion for drug delivery. Adv. Drug Delivery Rev. 5, 189-208.
29. Fingar, V. H., W. R. Potter and B. H. Henderson (1987) Drug and light dose dependence of photodynamic therapy: a study of tumor cell clonogenicity and histologic changes. Photochem. Photobiol. 45, 643-650.
30. Ward, B., C. K. Chang and R. Young (1984) Spectral shifts upon reversible modifications of CHO peripheral substituents in porphyrin, chlorin, and bacteriochlorin. A phenomenological explanation for the red shift of protonated Schiff base. J. Am. Chem. Soc. 106, 3943-3950.
31. Kessel, D. and Y. Luo (1998) Mitochondrial photodamage and PDT-induced apoptosis. J. Photochem. Photobiol. B Biol. 42, 89-95.