Clinical and antimicrobial effects of a single episode of subgingival irrigation with tetracycline HCl or chlorhexidine in deep periodontal pockets

Journal of Clinical Periodontology

Volumn 25, Issue 10, 1998, Pages 794-800

  Stabholz, Ayala ^a,e   Nicholas, Anne A ^b   Zimmerman, Grenith J ^c   Wikesjö, Ulf M E ^d  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b Loma Linda University ^*

^c LOMA LINDA UNIVERSITY   (United States)

^d PFIZER INC   (United States)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Chlorhexidine digluconate letracycline; HCl therapeutic use; Periodontal disease therapy

Indexed keywords

ANTIINFECTIVE AGENT; CHLORHEXIDINE; TETRACYCLINE; TOPICAL ANTIINFECTIVE AGENT;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BACTERIAL COUNT; CLINICAL TRIAL; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; HUMAN; LAVAGE; MICROBIOLOGY; NONPARAMETRIC TEST; OUTCOME ASSESSMENT; PERIODONTICS; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; COLONY COUNT, MICROBIAL; DOUBLE-BLIND METHOD; HUMANS; IRRIGATION; OUTCOME ASSESSMENT (HEALTH CARE); PERIODONTAL INDEX; PERIODONTAL POCKET; STATISTICS, NONPARAMETRIC; TETRACYCLINE;

EID: 0032184989     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.1998.tb02372.x     Document Type: Article

References (45)

1. Ainamo, J., Lie, T., Ellingsen, B. H., Hansen, B. F. Johansson, L. A., Karring, T., Kisch, J., Paunio, K. & Stoltze, K. (1992) Clinical responses to subgingival application of metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. Journal of Clinical Periodontology 19, 723-729.
2. Baker, P. J., Evans, R. T., Coburn, R. A. & Genco, R. J. (1983) Tetracycline and its derivatives strongly bind to and are released from the tooth surface in active form. Journal of Periodontology 54, 580-585.
3. Bjorvatn, K., Skaug, N. & Selvig, K. A. (1985) Tetracycline-impregnated enamel and dentin: duration of antimicrobial capacity. Scandinavian Journal of Dental Research 93, 192-197.
4. Christersson, L. A., Norderyd, O. M. & Puchalsky, C. S. (1993) Topical application of tetracycline-HCl in human periodontitis. Journal of Clinical Periodontology 20, 88-95.
5. Drisko, C. L., Cobb, C. M., Killoy, W. J., Michalowicz, B. S., Philstrom, B. L., Lowenguth, R. A., Caton, J. G., Encarnacion, M., Knowles, M. & Goodson, J. M. (1995) Evaluation of periodontal treatments using controlled-release tetracycline fibers: clinical response. Journal of Periodontology 66, 692-699.
6. Eckles, T. A., Reinhardt, R. A., Dyer, J. K., Tussing, G. L., Szydlowski, W. M. & DuBous, L.M. (1990) Intracrevicular application of tetracycline in white petrolatum for the treatment of periodontal disease. Journal of Clinical Periodontology 17, 454-462.
7. Emrich, L. J. (1990) Common problems with statistical aspects of periodontal research papers. Journal of Periodontology 61, 206-208.
8. Goodson, J. M., Holborow, D., Dunn, R. L., Hogan, P. & Dunham, S. (1983) Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets. Journal of Periodontology 54, 575-579.
9. Goodson, J. M., Offenbacher, S., Farr, D. H. & Hogan, P. E. (1985a) Periodontal disease treatment by local drug delivery. Journal of Periodontology 56, 265-272.
10. Goodson, J. M., Hogan, P. E. & Dunham, S. L. (1985b) Clinical responses following periodontal treatment by local drug delivery. Journal of Periodontology 56, 81-87.
11. Goodson, J. M., Cugini, M. A., Kent R. L., Armitage G. C., Cobb, C. M., Fine, D., Fritz, M. E., Green, E., Imoberdorf, M. J., Killoy, W. J., Mendieta, C., Niederman, R., Offenbacher, S., Taggart, E. J. & Tonetti, M. (1991a) Multicenter evaluation of tetracycline fiber therapy: (II). Clinical response. Journal of Periodontal Research 26, 371-379.
12. Goodson, J. M., Tanner, A., McArdle, S., Dix, K. & Watanabe, S. M. (1991b) Multicenter evaluation of tetracycline fiber therapy: (III). Microbiological response. Journal of Periodontal Research 26, 440-451.
13. Greenstein, G. (1992) Periodontal response to mechanical non-surgical therapy: A review. Journal of Periodontology 63, 118-130.
14. Heijl, L., Dahlén, G., Sundin, Y., Wenander, A. & Goodson, J. M. (1991) A four quadrant comparative study of periodontal treatment using tetracycline containing drug delivery fibers and scaling. Journal of Clinical Periodontology 18, 111-116.
15. Khoo, J. G. L. & Newman H. N. (1983) Subgingival plaque control by a simplified oral hygiene regime plus local chlorhexidine or metronidazole. Journal of Periodontal Research 18, 607-619.
16. Klinge, B., Attström, R., Karring, T., Kisch, J., Lewin, B. & Stoltze, K. (1992) 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. Journal of Clinical Periodontology 19, 708-714.
17. Kornman, K. S., Newman, M. G., Moore, D. J. & Singer, R. E. (1994) The influence of supragingival plaque control on clinical and microbial outcomes following the use of antibiotics for the treatment of periodontitis. Journal of Periodontology 65, 848-854.
18. Listgarten, M. A. & Helldén, L. (1978) Relative distribution of bacteria at clinically healthy and periodontally diseased sites in humans. Journal of Clinical Periodontology 5, 115-132.
19. Löe, H. & Silness, J. (1963) Periodontal disease in pregnancy (I). Prevalence and severity. Acta Odontologica Scandinavica 21, 533-551.
20. MacAlpine, R., Magnusson, I., Kiger, R., Crigger, M. & Egelberg, J. (1985) Antimicrobial irrigation of deep pockets to supplement oral hygiene instruction and root debridement (I): Bi-weekly irrigation. Journal of Clinical Periodontology 12, 568-577.
21. Macaulay, W.J. & Newman, H. N. (1986) The effect on the composition of subgingival plaque of simplified oral hygiene system including pulsating jet subgingival irrigation. Journal of Periodontal Research 21, 375-385.
22. McNabb, H., Mombelli, A. & Lang, N. P. (1992) Supragingival cleaning 3X a week. The microbiological effects in moderately deep pockets. Journal of Clinical Periodontology 19, 348-356.
23. Minabe, M., Takeuchi, K., Tamura, T., Hori, T. & Umemoto, T. (1989) Subgingival administration of tetracycline on a collagen film. Journal of Periodontology 60, 552-556.
24. Minabe, M., Takeuchi, K., Nishimura, T., Hori, T. & Umemoto, T. (1991) Therapeutic effects of combined treatment using tetracycline-immobilized collagen film and root planing in periodontal furcation pockets. Journal of Clinical Periodontology 18, 287-290.
25. Needleman, I. G. & Watts, T. L. P. (1989) The effect of 1% metronidazole gel in routine maintenance of persistent furcation involvement in human beings. Journal of Periodontology 60, 699-703.
26. Newman, M. G., Kornman, K. S. & Doherty, F. M. (1994) A six month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: Clinical results. Journal of Periodontology 65, 685-691.
27. Nylund, K. & Egelberg, J. (1990) Antimicrobial irrigation of periodontal furcation lesions to supplement oral hygiene instruction and root debridement. Journal of Clinical Periodontology 17, 90-95.
28. Okuda, K., Wolff, L., Oliver, R., Osborn, J., Stoltenberg, J., Bereuter, J., Anderson, L., Foster, P., Hardie, N., Aeppli, D. & Hara, K. (1992) Minocycline slow-release formulation. Effect on subgingival bacteria. Journal of Periodontology 63, 73-79.
29. Polson, A. M., Garrett, S., Stoller, N. H., Bandt, C. L., Hanes, P. J., Killoy, W. J., Southard, G. L., Duke, S. P., Bogle, G. C., Drisko, C. H. & Friesen, L. R. (1997) Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis (II). Clinical results. Journal of Periodontology 68, 119-126.
30. Rølla, G., Löe, H. & Schiøtt, C. R. (1970) The affinity of chlorhexidine for hydroxyapatite and salivary mucins. Journal of Periodontal Research 5, 90-95.
31. Rølla, G., Löe, H. & Schiøtt, C. R. (1971) Retention of chlorhexidine in the human oral cavity. Archives of Oral Biology 16, 1109-1116.
32. Silness, J. & Löe, H. (1964) Periodontal disease in pregnancy (II). Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica 22, 121-135.
33. Socransky, S. S., Haffajee, A. D. & Tanner, A. C. R. (1983) Statistical analysis of microbial counts of dental plaque. Journal of Periodontal Research 18, 187-199.
34. Soskolne, W. A., Heasman, P. A., Stabholz, A., Smart, G. J., Palmer, M., Flashner, M. & Newman, H. N. (1997) Sustained delivery of chlorhexidine in the treatment of periodontitis: A multi-center study. Journal of Periodontology 68, 32-38.
35. Stabholz, A., Sela, M. N., Friedman, M., Golomb, G. & Soskolne, A. (1986) Clinical and microbiological effects of sustained release chlorhexidine in periodontal pockets. Journal of Clinical Periodontology 13, 783-788.
36. Stabholz, A., Elkayam, R., Friedman, M., Sela, M. N., Azury, R. & Soskolne, W. A. (1989) Clinical and microbiological evaluation of sustained release device of tetracycline in periodontal pockets. Proceedings of the 5th International Conference of Pharmaceutical Technology vol. 2, 336-345.
37. Stabholz, A., Soskolne, W. A., Friedman, M. & Sela, M. N. (1991) The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets: 2 year clinical trial. Journal of Periodontology 62, 429-433.
38. Stabholz, A., Kettering, J., Aprecio, R., Zimmerman, G., Baker, P. J. & Wikesjö, U. M. E. (1993a) Retention of antimicrobial activity by human root surfaces after in situ subgingival irrigation with tetracycline HCl or chlorhexidine. Journal of Periodontology 64, 137-141.
39. Stabholz, A., Kettering, J., Aprecio, R., Zimmerman, G., Baker, P. J. & Wikesjö, U. M. E. (1993b) Antimicrobial properties of human dentin impregnated with tetracycline HCl or chlorhexidine. An in vitro study. Journal of Clinical Periodontology 20, 557-562.
40. Van Steenberghe, D., Bercy, P., Kohl, J., De Boever, J., Adriaens, P., Vanderfaeillie, A., Adriaenssen, C., Rompen, E., De Vree, H., McCarthy, F. & Vandenhoven, G. (1993) Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double-blind, vehicle-controlled, multicenter study. Journal of Periodontology 64, 637-644.
41. Turner, Y., Ashley, F. P. & Wilson, R. F. (1994) Effectiveness of oral hygiene with and without root planing in treating subjects with chronic periodontitis. British Dental Journal 177, 367-371.
42. Wennström, J. L., Heijl, L., Dahlén, G. & Gröndahl, K. (1987a) Periodic subgingival antimicrobial irrigation of periodontal pockets (I). Clinical observations. Journal of Clinical Periodontology 14, 541-550.
43. Wennström, J. L., Dahlén, G., Gröndahl, D. G. & Heijl, L. (1987b) Periodic subgingival antimicrobial irrigation of periodontal pockets (II). Microbiological and radiographical observations. Journal of Clinical Periodontology 14, 573-580.
44. Westling, M. & Tynelius-Bratthall, G. (1984) Microbial and clinical short-term effects of repeated intracrevicular chlorhexidine rinsing. Journal of Periodontal Research 19, 202-209.
45. Wikesjö, U. M. E., Baker, P. J., Christersson, L. A., Genco, R. J., Lyall, R. M., Hic, S., DiFlorio, R. M. & Terranova, V. P. (1986) A biochemical approach to periodontal regeneration: tetracyclinetreatment conditions dentin surfaces. Journal of Periodontal Research 21, 322-329.