Apolipoprotein E ε4 allele frequency is increased in Parkinson's disease only with co-existing Alzheimer pathology

Acta Neuropathologica

Volumn 96, Issue 4, 1998, Pages 417-420

  Mattila, P M ^a   Koskela, T ^b,c   Roytta M ^a   Lehtimaki T ^b,c   Pirttila T A ^b   Ilveskoski, E ^b,c   Karhunen, P ^c   Rinne, J O ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Alzheimer's disease; Apolipoprotein E; Genotype; Parkinson's disease; Polymerase chain reaction

Indexed keywords

APOLIPOPROTEIN E; DNA; ENZYME; APOLIPOPROTEIN E4;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENOTYPE; HISTOLOGY; HUMAN; HUMAN TISSUE; LEWY BODY; MALE; NEUROPATHOLOGY; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION MAPPING; RISK; SUBSTANTIA NIGRA; BRAIN; GENETICS; PATHOLOGY;

AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BRAIN; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; PARKINSON DISEASE; POLYMERASE CHAIN REACTION;

EID: 0032175345     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050913     Document Type: Article

References (27)

1. Agresti A (1990) Categorical Data Analysis. Wiley, New York, p 558
2. Arai H, Lee VM-Y, Hill WD, Greenberg BD, Trojanowski JQ (1992) Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Res 585: 386-390
3. Arai H, Muramatsu T, Higuchi S, Sasaki H, Trojanowski JW (1994) Apolipoprotein E gene in Parkinson's disease with or without dementia. Lancet 344: 889
4. Benjamin R, Leake A, Edwardson JA, McKeith IG, Ince PG, Perry RH, Morris CM (1994) Apolipoprotein E genes in Lewy body and Parkinson's disease. Lancet 343: 1565
5. Egensperger R, Bancher C, Kösel S, Jellinger K, Mehraein P, Graeber MB (1996) The apolipoprotein E ε4 allele in Parkinson's disease with Alzheimer lesions. Biochem Biophys Res Commun 224: 484-486
6. Emi M, Wu LL, Robertson MA, Myers RL, Hegele RA, Williams RL, White R, Landouel J-M (1988) Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics 3: 373-379
7. Galasko D, Saitoh T, Xia Y, Thal LJ, Katzman R, Hill LR, Hansen L (1994) The apolipoprotein E allele ε4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease. Neurology 44: 1950-1951
8. Gearing M, Schneider JA, Rebeck GW, Hyman BT, Mirra SS (1995) Alzheimer's disease with and without coexisting Parkinson's disease changes: apolipoprotein E genotype and neuropathologic correlates. Neurology 45: 1985-1990
9. Harrington CR, Louwagie J, Rossau R, Vammechelen E, Perry RH, Perry EK, Xuereb JH, Roth M, Wischik CM (1994) Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Am J Pathol 145: 1472-1484
10. Hixson JE, Vernier DT (1990) Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31: 545-548
11. Koller WC, Glatt SL, Hubble JP, Paolo A, Tröster AI, Handler MS, Horvat RT, Martin C, Schmidt K, Karst A, Wijsman EM, Yu C-E, Schellenberg GD (1995) Apolipoprotein E genotypes in Parkinson's disease with and without dementia. Ann Neurol 37: 242-245
12. Lippa CF, Smith TW, Nee L, Robitaille Y, Crain B, Dickson D, Pulaski-Salo D, Pollen DA (1995) Familial Alzheimer's disease and cortical Lewy bodies: is there a genetic susceptibility factor? Dementia 6: 191-194
13. Lippa CF, Smith TW, Saunders AM, Crook R, Pulaski-Salo D, Davies P, Hardy J, Roses AD, Dickson D (1995) Apolipoprotein E genotype and Lewy body disease. Neurology 45: 97-103
14. Marder K, Maestre G, Cote L, Meija H, Alfaro B, Halim A, Tang M, Tycko B, Mayeux R (1994) The apolipoprotein ε4 allele in Parkinson's disease with and without dementia. Neurology 44: 1330-1331
15. Mattila PM, Röyttä M, Torikka H, Dickson DW, Rinne JO (1998) Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease. Acta Neuropathol 95: 576-582
16. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson IA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen ENH, Ballard C, Vos RAI de, Wilcock GK, Jellinger KA, Perry RH, for the Consortium on Dementia with Lewy Bodies (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47: 1113-1124
17. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, Belle G van , Berg L, participating CERAD neuropathologists (1991) The Consortium to Establish a Registry tor Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41: 479-486
18. Mölsä PK, Säkö E, Paljärvi L, Rinne JO, Rinne UK (1987) Alzheimer's disease: neuropathological correlates of cognitive and motor disorders. Acta Neurol Scand 75: 376-384
19. Pickering-Brown SM, Mann DMA, Bourke JP, Roberts DA, Balderson D, Burns A, Byrne J, Owen F (1994) Apolipoprotein E4 and Alzheimer's disease pathology in Lewy body disease and in other β-amyloid-forming diseases. Lancet 343: 1155
20. Pickering-Brown S, Roberts D, Owen F (1994) Apolipoprotein E4 alleles and non-Alzheimer's disease forms of dementia. Neurodegeneration 3: 95-96
21. Pollanen MS, Bergeron C, Weyer L (1994) Characterization of a shared epitope in cortical Lewy body fibrils and Alzheimer paired helical filaments. Acta Neuropathol 88: 1-6
22. Reisberg B (1985) Alzheimer's disease update. Psychiatr Ann 15: 319-322
23. Rinne JO, Rummukainen J, Paljärvi L, Rinne UK (1989) Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra. Ann Neurol 26: 47-50
24. Saunders AM, Strittmatter WJ, Schmechel D, et al (1993) Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Azheimer's disease. Neurology 43: 1467-1472
25. Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD (1993) Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late onset Alzheimer disease. Proc Natl Acad Sci USA 90: 9649-9653
26. Schneider JA, Gearing M, Robbins RS, De l'Aune W, Mirra SS (1995) Apolipoprotein E genotype in diverse neurodegenerative disorders. Ann Neurol 38: 131-135
27. St Clair D, Norrman J, Perry R, Yates C, Wilcock G, Brookes A (1994) Apolipoprotein E ε4 allele frequency in patients with Lewy body dementia. Alzheimer's disease and age-matched controls. Neurosci Lett 176: 45-46