Establishment of an activated macrophage cell line, A-THP-1, and its properties

Tohoku Journal of Experimental Medicine

Volumn 186, Issue 2, 1998, Pages 99-119

  Tominaga, Tsuyoshi ^a   Suzuki, Masanori ^a   Saeki, Hisaaki ^b   Matsuno, Seiki ^a   Tachibana, Takehiko ^c   Kudo, Toshio ^b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c JAPAN IMMUNORESEARCH LABORATORIES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CARBOXYLESTERASE; COMPLEMENT RECEPTOR; CYTOKINE; FC RECEPTOR; HLA DR ANTIGEN; ISOENZYME; LACTATE DEHYDROGENASE; PROTEIN S 100;

ACUTE MONOCYTIC LEUKEMIA; ANEUPLOIDY; ARTICLE; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; HUMAN; HUMAN CHROMOSOME; KARYOTYPING; MACROPHAGE; MACROPHAGE ACTIVATION; MIXED LYMPHOCYTE CULTURE; MONOCYTE; PATHOLOGY; PHAGOCYTOSIS; PHENOTYPE; ROSETTE FORMATION; ULTRASTRUCTURE;

ACTINS; ANEUPLOIDY; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CELL ADHESION; CELL DIFFERENTIATION; CELL LINE; CHROMOSOMES, HUMAN; CYTOKINES; HLA-DR ANTIGENS; HUMANS; ISOENZYMES; KARYOTYPING; L-LACTATE DEHYDROGENASE; LEUKEMIA, MONOCYTIC, ACUTE; LYMPHOCYTE CULTURE TEST, MIXED; MACROPHAGE ACTIVATION; MACROPHAGES; MONOCYTES; PHAGOCYTOSIS; PHENOTYPE; RECEPTORS, COMPLEMENT; RECEPTORS, IGG; ROSETTE FORMATION; S100 PROTEINS; TUMOR CELLS, CULTURED;

EID: 0032174124     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.186.99     Document Type: Article

References (37)

1. Aiello, F.B., Longo, D.L., Overton, R., Takacs, L. & Durum, S.K. (1990) A role for cytokines in antigen presentation: IL-1 and IL-4 induce accessory functions of antigen-presenting cells. J. Immunol., 144, 2572-2581.
2. Anderson, C.L., Looney, R.J., Culp, D.J., Ryan, D.H., Fleit, H.B., Utell, M.J., Frampton, M.W., Manganiello, P.D. & Guyre, P.M. (1990) Alveolar and peritoneal macrophages bear three distinct classes of Fc receptors for IgG. J. Immunol., 145, 196-201.
3. Chen, T.R. (1977) In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp. Cell Res., 104, 255-262.
4. Crawford, R.M., Finbloom, D.S., Ohara, J., Paul, W.E. & Meltzer, M.S. (1987) B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J. Immunol., 139, 135-141.
5. Deo, Y.M., Granziano, R.F., Repp, R. & van de Winkel, J.G.J. (1997) Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies. Immunol. Today, 18, 127-135.
6. Geissler, K., Harrington, M., Strivastrava, C., Leemhuis, T., Tricot, G. & Broxmeyer, H.E. (1989) Effects of recombinant human colony stimulating factors (CSF) (Granulocyte-macrophage CSF, Granulocyte CSF and CSF-1) on human monocyte/ macrophage differentiation. J. Immunol., 143, 140-146.
7. Grabstein, K.H., Urdal, D.L., Tushinski, R.J., Mochizuki, D.Y., Price, V.L., Cantrell, M.A., Gillis, S. & Conlon, P.J. (1986) Induction of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor. Science, 232, 506-508.
8. Hassan, N.F., Kamani, N., Meszaros, M.M. & Douglas, S.D. (1989) Induction of multinucleated giant cell formation from human blood-derived monocytes by phorbol myristate acetate in in vitro culture. J. Immunol., 143, 2179-2184.
9. Hay, R.J., Macy, M.L. & Chen, T.R. (1989) Mycoplasma infection of cultured cells. Nature, 339, 487-488.
10. 2. J. Immunol., 143, 1198-1205.
11. Hoessly, M.C., Rossi, R.M. & Fischkoff, S.A. (1989) Factors responsible for variable reported lineages of HL-60 cells induced to mature with butyric acid. Cancer Res., 49, 3594-3597.
12. Hori, K., Mihich, E. & Ehrke, M.J. (1989) Role of tumor necrosis factor and interleukin 1 in γ-interferon-promoted activation of mouse tumoricidal macrophages. Cancer Res., 49, 2606-2614.
13. Hudson, M.M., Snyder, J.S., Jaffe, N. & Kleinerman, E.S. (1988) In vitro and in vivo effects of adriamycin therapy on monocyte activation by liposome-encapsulated immunomodulators. Cancer Res., 48, 5256-5263.
14. Imai, Y., Yamakawa, M., Sato, T. & Suda, A. (1989) Malignant fibrous histiocytoma: Similarities to the "fibrohistiocytoid cells" in chronic inflammation. Virchow Archiv-A, Pathological Anatomy & Histopathology, 414, 285-298.
15. Klaassen, R.J., Ouwehand, W.H., Huiznga, T.W., Engelfriet, C.P. & von dem Borne, A.E. (1990) The Fc-receptor III of cultured human monocytes. Structural similarity with FcRIII of natural killer cells and role in the extracellular lysis of sensitized erythrocytes. J. Immunol., 144, 599-606.
16. Kornbluth, R.S. & Edington, T.S. (1986) Tumor necrosis factor production by human monocytes is a regulated event: Induction of TNF α mediated cellular cytotoxicity by endotoxin. J. Immunol., 137, 2585-2591.
17. Kudo, T. & Tachibana, T. (1984a) Phenotype characteristics of human B cells studied by Epstein-Barr virus infection. II. C3 receptor switching during human B cell differentiation. Immunol. Lett., 6, 343-348.
18. Kudo, T. & Tachibana, T. (1984b) Phenotype characteristics of human B cells studied by Epstein-Barr virus infection. III. In vitro modulation of C3 receptor expression on human lymphoid cells. Immunol. Lett., 8, 349-353.
19. Landry, D., Lafontaine, M., Cossette, M., Barthelemy, H., Chartrand, C., Montplaisir, S. & Pelletier, M. (1988) Human thymic dendritic cells. Characterization, isolation and functional assays. Immunology, 65, 135-142.
20. Looney, R.J., Abraham, G.N. & Anderson, C.L. (1986) Human monocytes and U937 cells bear two distinct Fc receptors for IgG. J. Immunol., 136, 1641-1647.
21. McInnes, A. & Rennick, D.M. (1988) Interleukin 4 induces cultured monocytes/ macrophages to form giant multinucleated cells. J. Exp. Med., 167, 598-661.
22. Munn, D.H. & Cheung, N.K. (1989) Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays. J. Exp. Med., 170, 511-526.
23. Munn, D.H. & Cheung, N.K. (1990) Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony stimulating factor. J. Exp. Med., 172, 231-237.
24. Myones, B.L., Daizell, J.G., Hogg, N. & Ross, G.D. (1988) Neutrophil and monocyte cell surface p150, 95 has iC3b-receptor (CR4) activity resembling CR3. J. Clin. Invest., 82, 640-651.
25. Najar, H.M., Ruhl, S., Bru-Capdeville, A.C. & Peters, J.H. (1990) Adenosine and its derivatives control human monocyte differentiation into highly accessory cells versus macrophages. J. Leukoc. Biol., 47, 427-439.
26. Nasiell, M., Roger, V., Nasiell, K., Enstad, I., Vogel, B. & Bisther, A. (1972) Cytologic findings indicating pulmonary tuberculosis. I. The diagnostic significance of epitheloid cells and Langhans' giant cells found in sputum or bronchial secretions. Acta Cytol., 16, 146-151.
27. Numasaki, M., Fukuoka, Y., Kudo, T., Saeki, H., Tachibana, T., Motomiya, M. & Nukiwa, T. (1995) A novel human monoclonal antibody, TONO-1, reactive with T-lymphocytic leukemia cells. Int. J. Cancer, 62, 42-47.
28. Santamaria, P., Gehrz, R.C., Bryan, M.K. & Barbosa, J.J. (1989) Involvement of class II MHC molecules in the LPS-induction of IL-1/TNF secretions by human monocytes. Quantitative differences at the polymorphic level. J. Immunol., 143, 913-922.
29. Smith, P.D., Lamerson, C.L., Wong, H.L., Wahl, L.M. & Wahl, S.M. (1990) Granulocyte-macrophage colony-stimulating factor stimulates human monocyte accessory cell function. J. Immunol., 144, 3829-3834.
30. Stuart, P.M., Zlotnik, A. & Woodward, J.G. (1988) Induction of class I and class II MHC antigen expression on murine bone marrow-derived macrophages by IL-4 (B cell stimulatory factor 1). J. Immunol., 140, 1542-1547.
31. te Velde, A.A., Klomp, J.P., Yard, B.A., de Vries, J.E. & Figdor, C.G. (1988) Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4. J. Immunol., 140, 1548-1554.
32. te Velde, A.A., Huijbens, R.J., de Vries, J.E. & Figdor, C.G. (1990) IL-4 decreases FcγR membrane expression and FcγR-mediated cytotoxic activity of human monocytes. J. Immunol., 144, 3046-3051.
33. Tsuchiya, S., Yamabe, M., Yamaguchi, Y., Kobayashi, Y., Konno, T. & Tada, K. (1980) Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer, 26, 171-176.
34. Tsuchiya, S., Kobayashi, Y., Goto, Y., Okuyama, H., Nakae, S., Konno, T. & Tada, K. (1982) Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res., 42, 1530-1536.
35. Weinberg, J.B., Hobbs, M.M. & Misukonis, M.A. (1984) Recombinant human γ-interferon induces human monocyte polykaryon formation. Proc. Natl. Acad. Sci. USA, 81, 4554-4557.
36. Werner-Felmayer, G., Werner, E.R., Fuchs, D., Hausen, A., Reibnegger, G. & Wachter, H. (1990) Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment. Cancer Res., 50, 2863-2867.
37. Wood, G.S., Turner, R.R., Shiurba, R.A., Eng, L. & Warnke, R.A. (1985) Human dendritic cells and macrophages: In situ immunophenotypic definition of subsets that exhibit specific morphologic and microenvironmental characteristics. Am. J. Pathol., 119, 73-82.