Immunodetection and characterisation of soluble CD105-TGFβ complexes

Journal of Immunological Methods

Volumn 218, Issue 1-2, 1998, Pages 85-93

  Li, C G ^a   Wilson, P B ^b   Bernabeu, C ^c   Raab, U ^c   Wang, J M ^d   Kumar, S ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^d BD Technologies   (United States)

Author keywords

Breast cancer; CD105 TGF complex; ELISA; Plasma

Indexed keywords

ENDOGLIN; HORSERADISH PEROXIDASE; MONOCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BREAST CANCER; CHEMOLUMINESCENCE; COVALENT BOND; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LIGAND BINDING; MAJOR CLINICAL STUDY; MYOCARDIAL DISEASE; OLIGOMERIZATION; PRIORITY JOURNAL; RECEPTOR BINDING; RHEUMATOID ARTHRITIS; STROKE;

ANTIGENS, CD; BREAST NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LIGANDS; PRECIPITIN TESTS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; SENSITIVITY AND SPECIFICITY; SOLUBILITY; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE-1;

ARMORACIA RUSTICANA; GALLUS GALLUS; ORYCTOLAGUS CUNICULUS;

EID: 0032170354     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(98)00118-5     Document Type: Article

References (26)

1. Attisano L., Carcamo J., Ventura F., Weis F.M.B., Massague J., Wrana J.L. Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors. Cell. 75:1993;671-680.
2. Blann A.D., Wang J.M., Wilson P.B., Kumar S. Serum levels of TGFβ receptor are increased in atherosclerosis. Atherosclerosis. 120:1996;221-226.
3. Border W.A., Noble N.A. Transforming growth factor β in tissue fibrosis. N. Engl. J. Med. 331:1994;1286-1292.
4. Cheifetz S., Bellon T., Cales C., Vera S., Bernabeu C., Massague J., Letarte M. Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells. J. Biol. Chem. 267:1992;19027-19030.
5. Derynck R., Jarrett J.A., Chen E.Y., Eaton D.H., Bell J.R., Assoian R.K., Roberts A.B., Sporn M.B., Goeddel D.V. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature. 316:1985;701-705.
6. Fremeaux-Bacchi V., Bernard I., Meillet F., Mani J.C., Fontaine M., Bonnefoy J.Y., Kazatchine M.D., Fischer E. Human lymphocyte shed a soluble form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that binds iC3b and CD23. Eur. J. Immunol. 26:1996;1497-1503.
7. Hartsough M.T., Mulders K.M. Transforming growth factor β activation of p44 in proliferating cultures of epithelial cells. J. Biol. Chem. 270:1995;7117-7124.
8. Herzinger T., Wolf D.A., Eick D., Kind P. The pRb-related protein p130 is a possible effector of transforming growth factor β1 induced cell cycle arrest in keratinocytes. Oncogene. 10:1995;2079-2084.
9. Krupinski J., Kaluza J., Kumar P., Kumar S., Wang J.M. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 25:1994;1794-1798.
10. Kumar S., Wang J.M., Bernabeu C. CD105 and angiogenesis. J. Pathol. 178:1996;363-366.
11. Lastres P., Letamendia A., Zhang H., Rius C., Almendro N., Raab U., Lopez L.A., Langa C., Fabra A., Letarte M., Bernabeu C. Endoglin modulates cellular responses to TGFβ1. J. Cell Biol. 133:1996;1109-1121.
12. Letarte, M., Greaves, A., Vera, S., 1995. CD105 (endoglin) cluster report. In: Stuart, F., et al. (Eds.), Leucocyte Typing V, White Cell Differentiation Antigens. Oxford Univ. Press, Oxford, p. 1756-1759.
13. McAllister K.A., Grogg K.M., Johnson D.W., Gallione C.J., Baldwin M.A., Jackson C.E., Helmbold E.A., Markel D.S., McKinnon W.C., Murrell J., McCormick M.K., Pericak-Vance M.A., Heutink P., Oostra B.A., Haitjema T., Westerman C.J.J., Porteous M.E., Guttmacher A.E., Letarte M., Marchuk D.A. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat. Genet. 8:1994;345-351.
14. O'Connor-McCourt M., Wakefield L.M. Latent transforming growth factor-β in serum. J. Biol. Chem. 262:1987;14090-14099.
15. Pichuantes S., Vera S., Bourdeau A., Pece N., Kumar S., Wayner E.A., Letarte M. Mapping epitopes to distinct regions of the extracellular domain of endoglin using bacterially expressed recombinant fragments. Tissue Antigens. 50:1997;265-276.
16. Porteous M.E.M., Burn J., Proctor S.J. Hereditary haemorrhagic telangiectasia: a clinical analysis. J. Med. Genet. 29:1992;527-530.
17. Raab, U., Langa, C., Letamendia, A., Lastres, P., Paez, E., Bernabeu, C., 1998. Characterisation of anti-CD105 monoclonal antibodies using recombinant vaccinia virus. In: Kishimoto, T., et al. (Eds.), Leucocyte typing VI. Garland Publishing, New York, in press.
18. RayChaudhury A., D'Amore P.A. Endothelial cell regulation by transforming growth factor-β J. Cell Biochem. 47:1991;224-229.
19. Roberts A.B., Sporn M.B. Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors. 8:1993;1-9.
20. Seon B.K., Matsuno F., Haruta Y., Kondo M., Barcos M. Long-lasting complete inhibition of human solid tumours in SCID mice by targeting endothelial cells of tumour vasculature with antihuman endoglin immunotoxin. Clin. Cancer Res. 3:1997;1031-1044.
21. Wang J.M., Kumar S., Pye D., van Agthoven A., Krupinski J., Hunter R.D. A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues. Int. J. Cancer. 54:1993;363-370.
22. Wang J.M., Kumar S., Pye D., Haboubi N., al-Nakib L. Breast carcinoma: comparative study of tumour vasculature using two endothelial cell markers. J. Natl. Cancer Inst. 86:1994;386-388.
23. Wang J.M., Wilson P.B., Kumar S., Pye D., Hunter R.D. Quantitation of endothelial cell specific protein E9 employing a single monoclonal antibody in an indirect sandwich ELISA. J. Immunol. Methods. 171:1994;55-64.
24. Wang J.M., Kumar S., van Agthoven A., Kumar P., Pye D., Hunter R.D. Irradiation induces up-regulation of E9 protein in human vascular endothelial cells. Int. J. Cancer. 62:1995;791-796.
25. Westphal J.R., Willems H.W., Schalkwijk C.J., Ruiter D.J., De-Waal R.M. Characteristics and possible function of endoglin, a TGF-β binding protein. Behring Inst. Mitt. 92:1993;15-22.
26. Yamashita H., Ichijo H., Grimsby S., Moren A., ten-Dijke P., Miyazono K. Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-β J. Biol. Chem. 269:1994;1995-2001.