A polyethylene glycol copolymer for carrying and releasing multiple copies of cysteine-containing peptides

Bioconjugate Chemistry

Volumn 9, Issue 5, 1998, Pages 612-617

  Huang, Shaei Yun ^a   Pooyan, Shahriar ^a,b   Wang, Jihong ^a   Choudhury, Indrani ^b   Leibowitz, Michael J ^b,c   Stein, Stanley ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COVALENT BONDS; ETHYLENE GLYCOL; FUNCTIONAL POLYMERS; GENE EXPRESSION; PEPTIDES; POLYOLS; SULFUR COMPOUNDS; VIRUSES;

COUPLING RATIOS; CYSTEAMINE; CYSTEINE-CONTAINING PEPTIDES; DISULPHIDE BONDS; NEUTRAL PH; PROCEDURE A; PROPANETHIOL; REDUCING ENVIRONMENT; RELEASE RATE; THIOL GROUPS;

POLYETHYLENE GLYCOLS;

EID: 0032170071     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc980038p     Document Type: Article

References (12)

1. Duncan, R., and Kopacek, J. (1984) Soluble synthetic polymers as potential drug carriers. Adv. Polym. Sci. 57, 53-101.
2. Zalipsky, S. (1995) Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates. Bioconj. Chem. 6, 150-165.
3. Davis, S., Abuchowski, A., Park, Y. K., and Davis, F. F. (1981) Alteration of the circulating half-life and antigenic properties of bovine adenosine deaminase in mice by attachment of poly(ethylene glycol). Clin. Exp. Immunol. 46, 649-652.
4. Nathan, A., Zalipsky, S., Ertel, S. L, Agathos, S. N., Yarmush, M. L., and Kohn, J. (1993) Copolymers of lysine and poly(ethylene glycol): A new family of functionalized drug carriers. Bioconj. Chem. 4, 54-62.
5. Woghiren, C., Sharma, B., and Stein, S. (1993) Protected thiol-poly(ethylene glycol): A new activated polymer for reversible protein modification. Bioconj. Chem. 4, 314-318.
6. Grassetti, D. R., and Murray. J. R. (1967) Determination of sulfhydryl groups with 2, 2′-or 4, 4′-dithiodipyridine. Arch. Biochem. Biophys. 119, 41-49.
7. Riddles, P. W., Blakeley, R. L., and Zerner, B. (1979) Ellman's reagent: 5,5′-Dithiobis(2-nitrobenzoic acid)-a reexamination. Anal. Biochem. 94, 75-81.
8. Choudhury, I., Wang, J., Rabson, A. B., Stein, S., Pooyan, S., Stein, S., and Leibowitz, M. J. (1998) Inhibition of HIV-1 replication by a Tat RNA-binding domain peptide analogue. J. Acquired Immune Defic. Syndr. 17, 104-111.
9. Goff, D. A., and Carroll, S. F. (1990) Substituted 2-iminothiolanes: Reagents for the preparation of disulfide cross-linked conjugates with increased stability. Bioconjugate Chem. 1, 381-386.
10. Trimble, S. P., Marquardt, D., and Anderson, D. C. (1997) Use of designed peptide linkers and recombinant hemoglobin mutants for drug delivery: In vitro release of an angiotensin II analogue and kinetic modeling of delivery. Bioconj. Chem. 8, 416-423.
11. Meister, A., Griffith, O. W., and Tate, S. S. (1979) New aspects of glutathione metabolism and translocation in mammals. Ciba Found. Symp. 72, 135-161.
12. Meister, A. (1991) Glutathione deficiency produced by inhibition of its synthesis and its reversal; applications in research and therapy. Pharmacol. Ther. 51, 155-194.