Platelet glycoprotein IIb/IIIa inhibitor attenuates complement activation during in vitro ventricular assist circulation

ASAIO Journal

Volumn 44, Issue 5, 1998, Pages

  Serna, Dan L ^a   Huh, Joseph ^a   Ha, Hongphuc ^a   Parhizgar, Suzan S ^a   Chen, John C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CHEMICAL ACTIVATION; ENZYME INHIBITION; HEMODYNAMICS; IMPLANTS (SURGICAL); PROTEINS;

COMPLEMENT ACTIVATION; PLATELET GLYCOPROTEIN INHIBITORS; VENTRICULAR ASSIST CIRCULATION;

HEART VALVE PROSTHESES;

FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR INHIBITOR; SERINE PROTEINASE INHIBITOR; TIROFIBAN; UNCLASSIFIED DRUG;

ARTICLE; ASSISTED CIRCULATION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; HEART INDEX; HEART PROTECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; PROTEIN ANALYSIS; SECRETORY GRANULE;

EID: 0032169971     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002480-199809000-00006     Document Type: Article

References (12)

1. Pennington DG, McBride LR, Peigh PS, Miller LW, Swartz MT: Eight years' experience with bridging to cardiac transplantation. J Thorac Cardiovasc Surg 107: 472-481, 1994.
2. King B, Serna DL, Huh J, Jalal R, Tran L, Chen JC: Evidence for degradation of platelet GP IIb/IIIa receptor after prolonged in vitro ventricular assist (Abstract). J Invest Med 46: 69A, 1998.
3. Ha H, Serna DL, Tenner A, Chen JC: Classical pathway of complement is activated in an in vitro ventricular assist device (Abstract). J Invest Med 46: 135A, 1998.
4. Schapira M, Scott CF, Colman RW: Contribution of plasma protease inhibitors to the inactivation of kallikrein in plasma. J Clin Invest 69: 462-468, 1982.
5. Van der Graff F, Koedam JA, Bouma BN: Inactivation of kallikrein in human plasma. J Clin Invest 71: 149-159, 1983.
6. Forbes CD, PenskyJ, Ratnoff OD: Inhibition of activated Hageman factor and activated thromboplastin antecedent by purified C1 inactivator. J Lab Clin Med 52: 1402-1409, 1970.
7. Schreiber AD, Kaplan AP, Austen KF: Plasma inhibitors of the components of the fibrinolytic pathway in man. J Clin Invest 52: 1402-1409, 1973.
8. Laurell AB, Johnson U, Martensson U, Sjoholm AG: Formation of complexes composed of C1 r, C1s, and C1 inactivator in human serum on activation of C1. Acta Pathol Microbiol Scand Sect C Immunol 86: 299-306, 1978.
9. Schmaier AH, Smith PM, Colman RW: Platelet C1 inhibitor, a secreted alpha-granule protein. J Clin Invest 75: 242-50, 1985.
10. Downing SW, Edmunds LH Jr: Release of vasoactive substances during cardiopulmonary bypass. Ann Thorac Surg 54: 1236-1243, 1992.
11. DiSilav WD, Eiselle JW, Lepow IH: Complement as a mediator of information. J Exp Med 126: 1027-1048, 1967.
12. Del Balza UH, Levi R, Polley MJ: Cardiac dysfunction caused by purified human C3a anaphylatoxin. Proc Natl Acad Sci U S A 82: 886-890, 1985.