Asymmetric contribution to Ig repertoire diversity by Vκ exons: Differences in the utilization of Vκ10 exons

Journal of Immunology

Volumn 161, Issue 5, 1998, Pages 2290-2300

  Fitzsimmons, Sean P ^a   Rotz, Benjamin T ^a   Shapiro, Marjorie A ^a  

^a Center for Biologics Evaluation/Res   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; EXON; GENE EXPRESSION; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; TATA BOX;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BONE MARROW; CLONING, MOLECULAR; EXONS; FETUS; GENE EXPRESSION; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LIVER; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RETROELEMENTS; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SPLEEN;

EID: 0032169196     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Wu, G., R. Juenichen, and H. G. Zachau. 1996. The mouse immunoglobulin κ locus contains about 140 variable gene segments. Eur. J. Immunol. 26:1613.
2. Brodeur, P. H., and R. Riblet. 1984. The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14:922.
3. Kofler, R., S. Geley, H. Kofler, and A. Helmberg. 1992. Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses. Immunol. Rev. 128:5.
4. Stiernholm, N. B. J., and N. L. Berinstein. 1995. A mutated promoter of a human Ig Vλ gene segment is associated with reduced germ-line transcription and a low frequency of rearrangement. J. Immunol. 154:1748.
5. Schlissel, M. S., and T. Morrow. 1994. Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination. J. Immunol. 153:1645.
6. H promoters in vitro. J. Immunol. 155:4270.
7. Goodnow, C. C., J. J. Cyster, S. B. Hartley, S. E. Bell, M. P. Cooke, J. I. Healy, S. Akkaraju, J. C. Rathmell, S. L. Pogue, and K. P. Shokat. 1995. Self-tolerance checkpoints in B lymphocyte development. Abv. Immunol. 59:279.
8. Hachemi-Rachedi, S., A. Cumano, A.-M. Drapier, P.-A. Cazenave, and P. Sanchez. 1997. Does positive selection determine the B cell repertoire? Eur. J. Immunol. 27:1069.
9. Grandien, A., Y. Modigliani, A. Freitas, J. Andersson, and A. Coutinho. 1994. Positive and negative selection of antibody repertoires during B cell differentiation. Immunol. Rev. 137:53.
10. H gene segments in pre-B cell lines. Nature 311:727.
11. H genes. Science 227:1597.
12. H gene family expression. J. Exp. Med. 168:589.
13. H exons in the primary repertoire of adult BALB/c mice. J. Immunol. 151:5364.
14. H-gene groups and may be random. Eur. J. Immunol. 15:1154.
15. Manser, T., S.-Y. Huang, and M. L. Gefter. 1984. Influence of clonal selection on the expression of immunoglobulin variable region genes. Science 226:1283.
16. H families in adult C57BL/6 and BALB/c mice. J. Exp. Med. 166:163.
17. Alt, F. W., T. K. Blackwell, and G. D. Yancopoulos. 1987. Development of the primary antibody repertoire. Science 238:1079.
18. H gene families. J. Exp. Med. 168:417.
19. H paradigm. J. Exp. Med. 169:1859.
20. Teale, J. M., and E. G. Morris. 1989. Comparison of Vκ gene family expression in adult and fetal B cells. J. Immunol. 143:2768.
21. Lawler, A. M., J. F. Keamey, M. Kuehl, and P. J. Gearhart. 1989. Early rearrangements of genes encoding murine immunoglobulin κ chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus. Proc. Natl. Acad. Sci. USA 86:6744.
22. Shapiro, M. A., and M. Weigert. 1987. How immunoglobulin genes rearrange. J. Immunol. 139:3834.
23. Medina, C. A., and J. M. Teale. 1993. Restricted κ chain expression in early ontogeny: biased utilization of Vκ exons and preferential Vκ-Jκ recombinations. J. Exp. Med. 177:1317.
24. Ramsden, D. A., C. J. Paige, and G. E. Wu. 1994. κ light chain rearrangement in mouse fetal liver. J. Immunol. 153:1150.
25. Goodhardt, M., P. Cavelier, N. Doyen, S. Kallenbach, C. Babinet, and F. Rougeon. 1993. Methylation status of immunoglobulin κ gene segments correlates with their recombination potential. Eur. J. Immunol. 23:1789.
26. Hsieh, C.-L., and M. R. Lieber. 1992. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J. 11:315.
27. Engler, P., D. Haasch, C. A. Pinkert, L. Doglio, M. Glymour, R. Brinster, and U. Storb. 1991. A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene Ioci. Cell 65:939.
28. H gene segments. Cell 40:271.
29. Blackwell, T. K., M. W. Moore, G. D. Yancopoulos, H. Suh, S. Lutzker, E. Selsing, and F. W. Alt. 1986. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature 324:585.
30. H transcripts. J. Exp. Med. 173:1529.
31. Schlissel, M. S., and D. Baltimore. 1989. Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription. Cell 58:1001.
32. Martin, D., R. Q. Huang, T. LeBien, and B. Van Ness. 1991. Induced rearrangement of κ genes in the BLIN-1 human pre-B cell line correlates with germline J-Cκ and Vκ transcription. J. Exp. Med. 173:639.
33. Ramsden, D. A., and G. E. Wu. 1997. Mouse κ light-chain recombination signal sequences mediate recombination more frequently than do those of λ light chains. Proc. Natl. Acad. Sci. USA 88:10721.
34. Hesse, J. E., M. R. Lieber, K. Mizuuchi, and M. Gellert. 1989. V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3:1053.
35. Buchanan, K. L., E. A. Smith, S. Dou, L. M. Corcoran, and C. F. Webb. 1997. Family-specific differences in transcription efficiency of Ig heavy chain promoters. J. Immunol. 159:1247.
36. Strohal, R., A. Helmberg, G. Kroemer, and R. Kofler. 1989. Mouse Vκ gene classification by nucleic acid sequence similarity. Immunogenetics 30:475.
37. Sanz, I., and J. D. Capra. 1987. Vκ and Jκ gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proc. Natl. Acad. Sci. USA 84:1085.
38. Kelley, D. E., L. M. Wiedemann, A. C. Pittet, S. Strauss, K. J. Nelson, J. Davis, B. Van Ness, and R. P. Perry. 1985. Nonproductive κ immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation. Mol. Cell. Biol. 5:1660.
39. L usage by anti-bacterial levan monoclonal antibodies. J. Immunol. 148:3864.
40. Kavaler, J., A. J. Caton, L. M. Staudt, D. Schwartz, and W. Gerhard. 1990. A set of closely related antibodies dominates the primary antibody response to the antigenic site Cb of the A/PR/8/34 influenza virus hemagglutinin. J. Immunol. 145:2312.
41. Pennycook, J., A. J. Marshall, and G. E. Wu. 1997. PCR assays for endogenous Ig gene rearrangement. In Immunology Methods Manual. I. Lefkovits, ed. Academic Press, New York, p. 250.
42. Kim, S.-O., I. Sanz, C. Williams, J. D. Capra, and P. D. Gottlieb. 1991. Polymorphism in Vκ10 genes encoding L chains of antibodies bearing the Ars-A and A48 cross-reactive idiotypes. Immunogenetics 34:231.
43. Kalled, S., and P. H. Brodeur. 1991. Utilization of Vκ families and Vκ exons. J. Immunol. 147:3194.
44. Falkner, F. G., and H. G. Zachau. 1984. Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements. Nature 310:71.
45. Parslow, T. G., D. L. Blair, W. J. Murphy, and D. K. Granner. 1984. Structure of the 5′ ends of immunoglobulin genes: a novel conserved sequence. Proc. Natl. Acad. Sci. USA 81:2650.
46. Queen, C., J. Foster, C. Stauber, and J. Stafford. 1986. Cell-type specific regulation of a κ immunoglobulin gene by promoter and enhancer elements. Immunol. Rev. 89:49.
47. Wirth, T., L. Staudt, and D. Baltimore. 1987. An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Nature 329:174.
48. Atchison, M. A., V. Delmas, and R. P. Perry. 1990. A novel upstream element compensates for an ineffectual octamer motif in an immunoglobulin Vκ promoter. EMBO J. 9:3109.
49. Ephrussi, A., G. M. Church, S. Tonegawa, and W. Gilbert. 1985. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134.
50. Hogbom, E., A.-C. Magnusson, and T. Leanderson. 1991. E-boxes as promoter elements in B cell lines and untransformed B lymphocytes. Scand. J. Immunol. 33:615.
51. Siden, E. J., D. Baltimore, D. Clark, and N. E. Rosenberg. 1979. Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell 16:389.
52. Nelson, K. J., E. L. Mather, and R. P. Perry. 1984. Lipopolysaccharide-induced transcription of the κ immunoglobulin locus occurs on both alleles and is independent of methylation status. Nucleic Acids Res. 12:1911.
53. Hardy, R. R., J. L. Dangl, K. Hayakawa, G. Jager, and L. A. Herzenberg. 1986. Frequent A light chain gene rearrangement and expression in a Ly-1 B lymphoma with a productive κ chain allele. Proc. Natl. Acad. Sci. USA 83:1438.
54. + B cell lymphoma. Nature 322:843.
55. Eckhardt, L. A., and L. A. Herzenberg. 1980. Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression. Immunogenetics 11:275.
56. Coffman, R. L. 1998. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69:5.
57. Clarke, S., and S. McCray. 1991. A shared κ reciprocal fragment and a high frequency of secondary Jκ5 rearrangements among influenza hemagglutinin specific B cell hybridomas. J. Immunol. 146:343.
58. Kalled, S. L., and P. H. Brodeur. 1990. Preferential rearrangement of Vκ4 gene segments in pre-B cell lines. J. Exp. Med. 172:559.
59. Hutchison, C. A. III, S. C. Hardies, D. D. Loeb, W. R. Shehee, and M. H. Edgell. 1989. LINEs and related retrotransposons: long interspersed repeated sequences in the eukaryotic genome. In Mobile DNA. D. E. Berg and M. M. Howe, eds. American Society for Microbiology, Washington, DC, pp. 593-617.
60. Sollbach, A., A. Marshall, C. Yu, J. Pennycook, and G. E. Wu. 1994. Understanding patterns of immunoglobulin gene rearrangements. Semin. Immunol. 6:197.
61. H and Vκ regions of monoclonal antibodies bearing the A48 regulatory idiotype. J. Immunol. 144:614.
62. Marion, T. N., D. M. Tillman, and N.-T. Jou. 1990. Interclonal and intraclonal diversity among anti-DNA antibodies from an (NZB X NZW)F-1 mouse. J. Immunol. 145:2322.
63. Kabat, E. A., T. T. Wu, M. Reid-Miller, H. M. Perry, and K. S. Gottesman. 1987. Sequences of Proteins of Immunological Interest. U.S. Department of Public Health and Human Services, National Institutes of Health, Bethesda, MD.
64. Bentley, D. L., and T. H. Rabbits. 1980. Human immunoglobulin variable region genes: DNA sequences of two V κ genes and a pseudogene. Nature 288:730.
65. Baumruker, T., R. Sturm, and W. Herr. 1988. OBP100 binds remarkably degenerated octamer motifs through specific interactions with flanking sequences. Genes Dev. 2:1400.
66. Sigvardsson, M., and T. Leanderson. 1994. Positive transcriptional control elements within the SP6 κ promoter decamer 3′ flanking sequence. Mol. Immunol. 31:1005.
67. Wilson, R., and U. Storb. 1983. Association of two different repetitive DNA elements near immunoglobulin light chain genes. Nucleic Acids Res. 11:1803.
68. Gebhard, W., T. Meitinger, J. Hochtl, and H. G. Zachau. 1982. A new family of interspersed repetitive DNA sequences in the mouse genome. J. Mol. Biol. 157:453.
69. Gebhard, W., and H. G. Zachau. 1983. Organization of the R family and other interspersed repetitive DNA sequences in the mouse genome. J. Mol. Biol. 170:255.
70. H-associated LINE-1 element with the expressed IgH cluster in a murine myeloma cell line. J. Immunol. 154:201.
71. Martin, S. L., and D. Branciforte. 1993. Synchronous expression of LINE-1 RNA and protein in mouse embryonal carcinoma cells. Mol. Cell. Biol. 13:5383.
72. Leibold, D. M., G. D. Swergold, M. F. Singer, R. E. Thayer, B. A. Dombrowski, and T. G. Fanning. 1990. Translation of LINE-1 DNA elements in vitro and in human cells. Proc. Natl. Acad. Sci. USA 87:6990.
73. H structure of the μ/surrogate L chain receptor. EMBO J. 15:1524.