3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: A novel class of central nicotinic receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 9, 1998, Pages 1623-1629

  Olesen, Preben H ^a   Swedberg, Michael D B ^a   Rimvall, Karin ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

3 (5 Alkylamino 4 isoxazolyl) 1,2,5,6 tetrahydropyridine; Agonist; Antagonist; Cholinergic channel modulators; Functional activity; Nicotinic; Subtype selectivity

Indexed keywords

3 (5 ALKYLAMINO 4 ISOXAZOLYL) 1,2,5,6 TETRAHYDROPYRIDINE DERIVATIVE; ARECOLINE; LOBELINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; DOPAMINE RELEASE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; RECEPTOR AFFINITY;

ANIMALS; CEREBRAL CORTEX; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; SPODOPTERA;

EID: 0032169090     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00101-1     Document Type: Article

References (26)

1. William, M.; Sullivan, J. P.; Arneric, S. P. Drug News Perspect. 1994, 7, 205.
2. Rosecrans, J. A.; Levin, E.; Karan, L. Med. Chem. Res. 1993, 2, 505.
3. Levin, E. D.; Rosecrans, J. A. Drug Dev. Res. 1994, 31, 1.
4. Arneric, S. P.; Sullivan, J. P.; Decker, M. W.; Brioni, J. D.; Bannon, A. W.; Briggs, C. A.; Donelly-Roberts, D.; Radek, R. J.; Marsh, K. M.; Kyncl, J.; Williams, M.; Buccafusco, J. J. A.D. Assoc. Disord. 1995, 9, 50.
5. Anderson, D. J.; Arneric, S. P. Eur. J. Pharmacol. 1994, 253, 261.
6. Toja, E.; Bonetti, C.; Butti, A.; Hunt, P.; Fortin, M.; Barzahhi, F.; Formento, M. L.; Maggioni, A.; Nencioni, A.; Galliani, G. Eur. J. Med. Chem. 1991, 26, 853.
7. Saunders, J.; MacLeod, A. M.; Merchant, K.; Showell, G. A.; Snow, R. J.; Street, L. J.; Baker, R. J. Chem. Soc., Chem. Commun. 1988, 1618.
8. Ward, J. S.; Merritt, L.; Calligaro, D. O.; Bymaster, F. P.; Shannon, H. E.; Sawyer, B. D.; Mitch, C. H.; Deeter, J. B.; Peters, S. C.; Sheardown, M. J., Olesen, P. H.; Swedberg, M. D. B.; Sauerberg, P. J. Med. Chem. 1995, 38, 3469.
9. Sauerberg, P.; Olesen, P.H.; Nielsen, S.; Treppendahl, S.; Sheardown, M. J.; Honoré, T.; Mitch, C. H.; Ward, J. S.; Pike, J. A.; Bymaster, F. P.; Sawyer, B. D.; Shannon, H. E. J. Med. Chem. 1992, 33, 2274.
10. Waters, J. A.; Spivak, C. E.; Hermsmeier, M.; Yadav, J. S.; Liang, R. F.; Gund, T. M. J. Med. Chem. 1988, 31, 545.
11. Spivak, C. E.; Waters, J. A.; Aronstam, R. S. J. Mol. Pharmacol. 1989, 36, 177.
12. Ward, J. S.; Merrit, L.; Bymaster, F. P.; Calligaro, D. O. Bioorg. Med. Chem. Lett. 1994, 4, 573.
13. Olesen, P. H.; Rimwall, K.; Eskesen, K.; Sheardown, M.; Egebjerg, J.; Tønder, E.; Judge, M. E.; Rasmussen, T.; Swedberg, M. D. B. Submitted to J. Pharmacol. Exp. Ther.
14. Abood, L. G.; Grassi, S. Biochem. Pharmacol. 1986, 35, 4199.
15. Boksa, P.; Quik, M.; Mitchell, J. B.; Collier, B.; O'Niel, W.; Quirion, R. Eur. J. Pharmacol. 1989, 173, 93.
16. Punzi, J. S.; Banerjee, S.; Abood, L. G. Biochem. Pharmacol. 1991, 41, 465.
17. Sauerberg, P.; Kindtler, J. W.; Nielsen, L.; Sheardown, M. J.; Honoré, T. J. Med. Chem. 1991, 34, 687.
18. Whiting, P. J.; Schoepfer, R.; Conroy, W. G.; Gore, M. J.; Keyser, K. T.; Shimasaki, S.; Esch, F.; Lindstrom, J. M. Mol. Brain Res. 1991, 10, 83.
19. Wada, E.; Wada, K.; Boulter, J.; Deneris, E.; Heinemann, S.; Patrick, J.; Swanson, L. W. J. Comp. Neurol. 1989, 284, 314.
20. Wonnacott, S.; Drasdo, A.; Sanderson, E.; Rowell, P. In The Biology of Nicotine Dependence; Bock, G.; Marsh, J., Eds.; Ciba Foundation: Chichester, 1990; Vol 87.
21. Grady, S. R.; Marks, M. J.; Collins, A. C. J. Neurochem. 1994, 62, 1390.
22. Reavill, C.; Stolerman, I. P. J. Psycopharmacol. 1987, 1, 264.
23. Swedberg, M. D. B.; Jacobsen, P.; Honore, T. J. Pharmacol. Exp. Ther. 1995, 274, 1113.
24. Lin, N-H.; He, Y.; Anderson, D. J.; Wasicak, J. T.; Kasson, R.; Sweeny, D.; Sullivan, J. P. Bioorg. Med. Chem. Lett. 1994, 4, 2389.
25. Dunkat, M.; Fiedler, W.; Dumas, D.; Damaj, I.; Martin, B. R.; Rosecrans, J. A.; James, J. R.; Glennon, R. A. Eur. J. Med. Chem. 1996, 31, 875.
26. Decker, M. W.; Brioni, J. D.; Bannon, A. W.; Arneric, S. P. Life Sci. 1995, 56, 545.