Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases

Molecular and Biochemical Parasitology

Volumn 95, Issue 1, 1998, Pages 153-158

  Gor, Dennis O ^a   Li, Albert C ^a   Wiser, Mark F ^b   Rosenthal, Philip J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TULANE UNIVERSITY   (United States)

Author keywords

Malaria; Plasmodium; Protease; Proteinase; SERA; SERPH

Indexed keywords

CYSTEINE PROTEINASE; PROTEINASE; SERINE REPEAT ANTIGEN; SERINE REPEAT ANTIGEN HOMOLOG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CONTROLLED STUDY; DNA LIBRARY; ENZYME ACTIVITY; MALARIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM; PLASMODIUM VINCKEI; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SCHIZONT; SHORT SURVEY;

ANIMALIA; PLASMODIUM VINCKEI; PLASMODIUM VIVAX;

EID: 0032168226     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(98)00097-8     Document Type: Article

References (22)

1. McKerrow JH, Sun E, Rosenthal PJ, Bouvier J The proteases and pathogenicity of parasitic protozoa. Annu Rev Microbiol. 47:1993;821-853.
2. Rosenthal PJ Proteases of malaria parasites: New targets for chemotherapy. Emerg Infect Dis. 4:1998;49-57.
3. Debrabant A, Delplace P Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum. Mol Biochem Parasitol. 33:1989;151-158.
4. 33 as a noncovalently associated complex with other fragments of the MSP1. Mol Biochem Parasitol. 50:1992;307-316.
5. Delplace P, Dubremetz JF, Fortier B, Vernes A A 50 kDa Plasmodium falciparum culture medium antigen specific of the merozoite release-reinvasion stage is processed from a 126 kDa schizont precursor. Mol Biochem Parasitol. 17:1985;239-251.
6. Bzik DJ, Li W-B, Horii T, Inselburg J Amino acid sequence of the serine-repeat antigen (SERA) of Plasmodium falciparum determined from cloned cDNA. Mol Biochem Parasitol. 30:1988;279-288.
7. Knapp B, Hundt E, Nau U, Küpper HA Molecular cloning, genomic structure and localization in a blood stage antigen of Plasmodium falciparum characterized by a serine stretch. Mol Biochem Parasitol. 32:1989;73-84.
8. Anders RF, Saul AJ Candidate antigens for an asexual blood stage vaccine against falciparum malaria. Good MF, Saul AJ Molecular Immunological Considerations in Malaria Vaccine Development. 1994;169-208 CRC Press, Boca Raton, FL.
9. Knapp B, Nau U, Hundt E, Küpper HA A new blood stage antigen of Plasmodium falciparum highly homologous to the serine-stretch protein SERP. Mol Biochem Parasitol. 44:1991;1-14.
10. Fox BA, Bzik DJ Analysis of stage-specific transcripts of the Plasmodium falciparum serine repeat antigen (SERA) gene and transcription from the SERA locus. Mol Biochem Parasitol. 68:1994;133-144.
11. Kiefer MC, Crawford KA, Boley LJ et al. Identification and cloning of a locus of serine repeat antigen (SERA)-related genes from Plasmodium vivax. Mol Biochem Parasitol. 78:1996;55-65.
12. Delplace P, Fortier B, Tronchin G, Dubremetz J, Vernes A Localization, biosynthesis, processing and isolation of a major 126 kDa antigen of the parasitophorous vacuole of Plasmodium falciparum. Mol Biochem Parasitol. 23:1987;193-201.
13. Higgins DG, McConnell DJ, Sharp PM Malarial proteinase? Nature. 340:1989;604.
14. Rosenthal PJ, Ring CS, Chen X, Cohen FE Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases. J Mol Biol. 241:1994;312-316.
15. Gor DO, Li AC, Rosenthal PJ Protective immune responses against protease-like antigens of the murine malaria parasite Plasmodium vinckei. Vaccine. 16:1998;1193-1202.
16. Eakin AE, Higaki JN, McKerrow JH, Craik CS Cysteine or serine proteinase? Nature. 342:1989;132.
17. Mottram JC, Coombs GH, North MJ Cysteine or serine proteinase? Nature. 342:1989;132.
18. Dufour E Sequence homologies, hydrophobic profiles and secondary structures of cathepsins B, H and L: Comparison with papain and actinidin. Biochimie. 70:1988;1335-1342.
19. Berti PJ, Storer AC Alignment/phylogeny of the papain superfamily of cysteine proteases. J Mol Biol. 246:1995;273-283.
20. Toebe CS, Clements JD, Cardenas L, Jennings GJ, Wiser MF Evaluation of immunogenicity of an oral Salmonella vaccine expressing recombinant Plasmodium berghei merozoite surface protein-1. Am J Trop Med Hyg. 56:1997;192-199.
21. Wiser MF, Schweiger HG Cytosolic protein kinase activity associated with the maturation of the malaria parasite Plasmodium berghei. Mol Biochem Parasitol. 17:1985;179-189.
22. Izumo A, Tanabe K, Kato M A method for monitoring the viability of malaria parasites (Plasmodium yoelii) freed from the host erythrocytes. Trans R Soc Trop Med Hyg. 81:1987;264-267.