Evidence against Anandamide as the Hyperpolarizing Factor Mediating the Nitric Oxide-Independent Coronary Vasodilator Effect of Bradykinin in the Rat1

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 3, 1998, Pages 1146-1151

  Fulton, David ^a   Quilley, John ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UMDNJ School of Osteopathic Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANANDAMIDE; ARACHIDONIC ACID; ARACHIDONIC ACID DERIVATIVE; BIOLOGICAL FACTOR; BRADYKININ; CYTOCHROME P450; ENDOTHELIUM DEPENDENT HYPERPOLARIZATION FACTOR; ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION FACTOR; NITRIC OXIDE; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; PYRAZOLE DERIVATIVE; RIMONABANT; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCIUM CHANNEL; CANNABINOID RECEPTOR; CHARYBDOTOXIN; CROMAKALIM; ICOSANOID; INDOMETACIN; NIFEDIPINE; POTASSIUM CHANNEL;

ANIMAL; ARTICLE; CORONARY BLOOD VESSEL; DOSE RESPONSE; DRUG EFFECT; MALE; METABOLISM; PHYSIOLOGY; RAT; VASODILATATION; WISTAR RAT; ANIMAL TISSUE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; DOSE TIME EFFECT RELATION; HEART PERFUSION; HYPERPOLARIZATION; INTRAVENOUS DRUG ADMINISTRATION; MEDIATOR RELEASE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; BIOLOGICAL FACTORS; BRADYKININ; CORONARY VESSELS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NITRIC OXIDE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNEL BLOCKERS; PYRAZOLES; RATS; RATS, WISTAR; VASODILATION;

EID: 0032160757     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Bauersachs J, Hecker M and Busse R (1994) Display of the characteristics of endothelium-derived hyperpolarising factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary microcirculation. Br J Pharmacol 113:1548-1553.
2. Bornheim LM, Kim KY, Chen B and Corraia MA (1993) The effect of cannabidiol on mouse hepatic microsomal cytochrome P450-dependent anandamide metabolism. Biochem Biophys Res Commun 197:740-746.
3. Campbell WB, Gebremedhin D, Pratt PF and Harder DR (1996) Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarising factors. Circ Res 78:415-423.
4. Devane WA, Hanus I, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-1949.
5. Edwards G, Zygmunt PM., Hogestatt ED and Weston AH (1996) Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. Br J Pharmacol 119:691-701.
6. Fukao M, Hattori Y, Kanno M, Sakuma I and Kitabatake A (1997) Evidence against a role of cytochrome P459-derived arachidonic acid metabolites in endotheliumdependent hyperpolarization by acetylcholine in rat isolated mesenteric artery. Br J Pharmacol 120:439-446.
7. Fulton D, McGiff JC and Quilley J (1992) Contribution of NO and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney. Br J Pharmacol 107:722-725.
8. Fulton D, Mahboubi K, McGiff JC and Quilley J (1995) Cytochrome P450-dependent effects of bradykinin in the rat heart. Br J Pharmacol 114:99-102.
9. Fulton D, McGiff JC and Quilley J (1994) Role of K channels in the vasodilator response to bradykinin in the rat heart. Br J Pharmacol 113:954-958.
10. Fulton D, McGiff JC and Quilley J (1996) Role of phospholipase C and phospholipase A2 in the nitric oxide-independent vasodilator effect of bradykinin in the rat perfused heart. J Pharmacol Exp Ther 278:518-526.
11. Furchgott RF and Zawadski JV ( 1980) The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373-376.
12. Hecker M, Bara AT, Bauersachs J and Busse R (1994) Characterisation of endothelium-derived hyperpolarising factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol 481:407-414.
13. Hu S and Kim HS (1993) Activation of K+ channels in vascular smooth muscle by cytochrome P450 metabolites of arachidonic acid. Ear J Pharmacol 230:215-221.
14. Laurent F, Michel A, Chapat JP and Boucard M (1993) Evaluation of the relaxant effects of SCA 40, a novel charybdotoxin-sensitive potassium channel opener in guinea pig isolated trachealis. Br J Pharmacol 108:622-626.
15. Ohlmann P, Martinez MC, Schneider F, Stoclet JC and Andriantsitohaina R (1997) Characterization of endothelium-derived relaxing factors released by bradykinin in human resistance arteries. Br J Pharmacol 121:657-664.
16. Oyekan AO, McGiff JC, Rosencrantz-Weiss P and Quilley J (1994) Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors. J Pharmacol Exp Ther 268:262-269.
17. Plane F, Holland M, Waldron GJ, Garland CJ and Boyle JP (1997) Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. Br J Pharmacol 121:1509-1511.
18. Popp R, Bauersachs J, Hecker M, Fleming I and Busse R (1996) A transferable, β-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells. J Physiol 497:699-709.
19. Pratt PF, Hillard CJ, Edgemond WS and Campbell WB (1998) N-arachidonylethanolamide relxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor. Am J Physiol 274:H375-H381.
20. Quilley J, McGiff JC and Fulton D (1997) Pharmacological evaluation of an epoxide (EET) as the putative mediator of cytochrome P450-dependent (P450) vasodilation to bradykinin (BK) in the rat heart. Hypertension 29:888 Abstr.
21. Rapacon M, Mieyal P, McGiff JC, Fulton D and Quilley J (1996) Contribution of calcium-activated potassiumchannels to the vasodilator effect of bradykinin in the isolated, perfused kidney of the rat. Br J Pharmacol 118:1504-1508.
22. Randall MD, Alexander SPH, Bennett T, Boyd EA, Fry JR, Gardiner SM, Kemp PA, McCulloch AI and Kendall DA (1996) An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem Biophys Res Commun 229:114-120.
23. Taylor SG and Weston AH (1988) Endothelium-derived hyperpolarizing factor: a new endogenous inhibitor from the vascular endothelium. Trends Pharmacol Sei 9:272-274.
24. White R and Hiley CR (1998) Studies on the effects of carrabinoid receptor ligands in the small mesenteric artery of the rat. Br J Pharmacol 123:65P.
25. Zygmunt PM, Edwards G, Weston AH, Davis SC and Hogestatt ED (1996) Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. Br J Pharmacol 118:1147-1152.