Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Pentazocine and Morphine in Normal Volunteers1

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 3, 1998, Pages 1197-1207

  Zacny, James P ^a   Hill, Joanna L ^a   Black, Matthew L ^a   Sadeghi, Parvine ^a  

^a THE UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; PENTAZOCINE; NARCOTIC AGENT;

ADULT; ARTICLE; DRUG EFFECT; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIOSIS; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR DISORDER; PSYCHOMOTOR PERFORMANCE; QUESTIONNAIRE; SWEATING; SYSTOLIC BLOOD PRESSURE; VISUAL DISORDER; VOMITING; BLOOD PRESSURE; CLINICAL TRIAL; COMPARATIVE STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE;

ADULT; BLOOD PRESSURE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MORPHINE; NARCOTICS; PENTAZOCINE; PSYCHOMOTOR PERFORMANCE; SEX FACTORS;

EID: 0032160076     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders-fourth edition. American Psychiatric Association, Washington DC.
2. Baddeley AD (1968) A three-minute reasoning test based on grammatical transformation. Psychonomic Sei 10:341-342.
3. Bailey PL and Stanley TH (1994) Intravenous opioid anesthetics, in Anesthesia. 4th ed. (Miller RD ed) pp 291-387, Churchill Livingstone, New York.
4. Barker J, Miller JD and Johnston IH (1972) The effect of pentazocine on pupillary size and intracranial pressure. Br J Anaesth 44:197-202.
5. Belleville JP, Dorey F and Bellville JW (1979) Effects of nefopam on visual tracking. Clin Pharmacol Ther 26:457-463.
6. Bellville JW and Green J (1965) The respiratory and subjective effects of pentazocine. Clin Pharmacol Ther 6:152-159.
7. Berkowitz BA, Asling JH, Shnider SM and Way EL (1969) Relationship of pentazocine plasma levels to pharmacological activity in man. Clin Pharmacol Ther 10:320-328.
8. Boccuni M, Cangi F, Fusco BM, Curradi C and Sicuteri F (1987) Pentazocine in migraine: Subjective and pupillary abnormal effects. Headache 27:503-508.
9. Bradley CM and Nicholson AN (1987) Studies on performance with aspirin and paracetamol and with the centrally acting analgesics meptazinol and pentazocine. Eur J Clin Pharmacol 32:135-139.
10. Brogden RN, Speight TM and Avery GS (1973) Pentazocine: A review of its pharmacological properties, therapeutic efficacy and dependence liability. Drugs 5:691.
11. Derogatis LR, Lipman RS and Covi L (1973) HSCL-90: An outpatient psychiatric rating scale-a preliminary report. Psychopharmacol Bull 9:13-17.
12. Forrest WH, Beer EG, Bellville JW, Ciliberti BJ, Miller EV and Paddock R (1969) Analgesic and other effects of the d- and Hsomers of pentazocine. Clin Pharmacol Ther 10:468-476.
13. Fraser HF and Rosenberg DE (1964) Studies on the human addiction liability of 2'-hydroxy-5, 9-dimethyl-2-(3,3-dimethylallyl)-6, 7-benzomorphan (WIN 20, 228): A weak narcotic antagonist. J Pharmacol Exp Ther 143:149-156.
14. Fräser HF, van Horn GG, Martin WR, Wolbach AB and Isbell H (1961) Methods for evaluating abuse liability. (A) Attitude of opiate addicts towards opiate-like drugs. (B) A short-term direct addiction test. J Pharmacol Exp Ther 133:311-387.
15. Gear RW, Gordon NC, Heller PH, Paul S, Miaskowski C and Levine JD (199(>a) Gender difference in analgesic response to the fcoppa-opioid pentazocine. Neurosci Lett 205:207-209.
16. Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH and Levine JD (199b) Xappo-opioids produce significantly greater analgesia in women than in men. Nature Med 2:1248-1250.
17. Haertzen CA (1966) Development of scales based on patterns of drug effects, using the Addiction Research Center Inventory (ARCI). Psychol Rep 18:163-194.
18. Hamilton RC, Dundee JW, Clarke RSJ, Loan WB and Morrison JD (1967) Studies of drugs given before anaesthesia. XIII: Pentazocine and other opiate antagonists. BrJAnaesth 39:647-656.
19. Hannington-Kiff JG (1970) Measurement of recovery from outpatient general anaosthesia with a simple ocular test. Br Med J 3:132-135.
20. Hirschhorn ID (1977) Pentazocine, cyclazocine and nalorphine as discriminative stimuli. Psychopharmacotogy 54:289-294.
21. Hoffmeister F and Schlichting UU ( 1972) Reinforcing properties of some opiates aad opioids in rhesus monkeys with histories of cocaine and codeine self-administration. Psychopharmacologia 23:55-74.
22. Jasinski DR, Martin WR and Hoeldtke RD (1970) Effects of short- and long-tenn administration of pentazocine in man. Clin Pharmacol Ther 11:385-403.
23. Kantor TG, Sunshine A, Laska E, Meisner M and Hopper M (1966) Oral analgesic studies: Pentazocine hydrochloride, codeine, aspirin and placebo and their influ-ence on response to placebo. Clin Pharmacol Ther 7:447-454.
24. Keats AS and Telford J (1964) Studies of analgesic drugs. VIII. A narcotic antagonist analgesic without psychotomimetic effects. J Pharmacol Exp Ther 143:157-164.
25. Manner T, Kanto J, Scheinin H and Scheinin M (1987) Meptazinol and pentazocine: Plasma catecholamines and other effects in healthy volunteers. Br J Clin Pharmacol 24:687-697.
26. Martin WR, Sloan JW, Sapira JD and Jasinski DR (1971) Physiologic, subjective,
27. Nuotto EJ and Korttila K (1991) Evaluation of a new computerized psychomotor test battery: Effects of alcohol. Pharmacol Toxicol 68:360-365.
28. Overton DA and Battfi SK ( 1979) Investigation of narcotics and antitussives using drug discrimination techniques. J Pharmacol Exp Ther 211:401-408.
29. Paddock R, Beer EG, Bellville JW, Ciliberti BJ, Forrest WH and Miller EV (1969) Analgesic and side effects of pentazocine and morphine in a large population of postoperative patients. Clin Pharmacol Ther 10:355-365.
30. Paivio A, Yulle JC and Madigan SA (1968) Concreteness, imagery, and meaningfulness values for 925 nouns. J Exp Psychol 768:1-25.
31. Physicians' Desk Reference, 50th ed. (1996) Medical Economics Company, Montvale, NJ
32. Preston KL and Bigelow GE (1994) Drug discrimination assessment of agonistantagonist opioids in humans: A three-choice saline-hydromorphone-butorphanol procedure. J Pharmacol Exp Ther 271:48-60.
33. Preston KL, Bigelow G, Bickel WK and Liebson IA (1989) Drug discrimination in human postaddicts: .Agonist-antagonist opioids. J Pharmacol Exp Ther 250:184-196.
34. Preston KL, Bigelow GE and Liebson IA (1987) Comparative evaluation of morphine, pentazocine and ciramadol in postaddicts. J Pharmacol Exp Ther 240:900-910.
35. Preston KL, Liebson IA and Bigelow GE (1992) Discrimination of agonist- antagonist opioids in humans trained on a two-choice saline-hydromorphone discrimination. J Pharmacol Exp Ther 261:62-71.
36. Reisine T and Pasternak G (1996) Opioid analgesics and antagonists, in Goodman and Giltnan's The Pharmacological Basis of Therapeutics. 9th ed (Hardman, JG, Oilman AG and Limbird LE eds) pp 521-555, Pergamon Press, New York.
37. Saarialho-Kere U, Mattila MJ and Seppala T (1986) Pentazocine and codeine: Effect on human performance and mood and interactions with diazepam. Med Biol 64:293-299.
38. Saarialho-Kere U, Mattila MJ and Seppala T (1988) Parenteral pentazocine: Effects on psychomotor skills and respiration, and interactions with amitriptyline. Ev.r J Pharmacol 35:483-489.
39. Schaefer GJ and Holtzman SG (1978) Discriminative stimulus effects of cyclazocir e in the squirrel monkey. J Pharmacol Exp Ther 205:291-301.
40. Schaefer GJ and Holtzman SG (1981) Morphine-like stimulus effects in the monkey: Opioids with antagonist properties. Pharmacol Biochem Behav 14:241-245.
41. Schuster CR, Smith BB and Jaffe JH (1971) Drug abuse in heroin users. An experimental study of self-administration of methadone, codeine and pentazocine. Arch Gen Psychiat 24:359-362.
42. Selzer ML (1971) The Michigan Alcoholism Screening Test: The quest for a new diagnostic instrument. Am J Psychiatr 127:89-94.
43. Shannon HE and Holtzman SG (1979) Morphine training dose: A determinant of stimulus generalization in the rat. Psychopharmacology 61:239-244.
44. Stacher G, Steinringer H, Winklehner S, Mittelbach G and Schneider C (1983) Effects of graded oral doses of meptazinol and pentazocine in comparison with placebo on experimentally induced pain in healthy humans. Br J Clin Pharmacol 16:149-156.
45. Stacher G, Steinringer H, Winklehner S and Schneider C (1982) Ceruletide increases threshold and tolerance to experimentally induced pain in healthy man. Peptides 3:955-962.
46. Steinfels GF, Young GA and Khazan N (1982) Self-administration of nalbuphine, butorphanol and pentazocine by morphine post-addict rats, Pharmacol Blochem Behav 16:167-171.
47. Thorndike EL and Lorge L ( 1944) The teacher's word book of 30,000 words. Columbia University Press, New York.
48. Wechsler D (1958) The Measurement and Appraisal of Adult Intelligence. Williams and Wilkins, Baltimore.
49. White JM and Holtzman JM (1982) Properties of pentazocine as a discriminative stimulus in the squirrel monkey. J Pharmacol Exp Ther 223:396-401.
50. Wood AJ, Moir DC, Campbell DC, Davidson JF, Gallon SC, Henney E and McAllion S (1974) Medicines evaluation and monitoring group: Central nervous system effects of pentazocine. Br Med J 1:305-307.
51. Zacny JP, Conley K and Marks S (1997) Comparing the subjective, psychomotor, and physiological effects of intravenous nalbuphine and morphine in healthy volunteers. J Pharmacol Exp Ther 280:1159-169.
52. Zacny JP, Lichtor JL, Thapar P, Coalson DW, Flemming D and Thompson W ( 1994) Comparing the subjective, psychomotor, and physiological effects of intravenous butorphanol and morphine in healthy volunteers. J Pharmacol Exp Ther 270:579588.