Characterization of the DNA-Binding and Dominant Negative Activity of v-erbA Homodimers

Molecular Endocrinology

Volumn 12, Issue 9, 1998, Pages 1380-1392

  Subauste, Jose S ^a,b   Koenig, Ronald J ^c  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b G V SONNY MONTGOMERY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GUANINE; ONCOPROTEIN; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR; URACIL; VITAMIN D;

ANIMAL; ARTICLE; CELL LINE; CONSENSUS SEQUENCE; DIMERIZATION; DNA METHYLATION; GENETIC TRANSFECTION; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE;

ANIMALS; BASE SEQUENCE; CELL LINE; CONSENSUS SEQUENCE; DIMERIZATION; DNA; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; GUANINE; MICE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS V-ERBA; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; TRANSFECTION; URACIL; VITAMIN D;

EID: 0032158788     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.9.0167     Document Type: Article

References (33)

1. Graf T, Beug H 1983 Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid cell transformation. Cell 34:7-9
2. Gandrillon O, Jurdic P, Benchaibi M, Xiao JH, Ghysdael J, Samarut J 1987 Expression of the v-erbA oncogene in chicken embryo fibroblasts stimulates their proliferation in vitro and enhances tumor growth in vivo. Cell 49:687-697
3. Frykberg L, Palmieri S, Beug H, Graf T, Hayman M, Vennstrom B 1983 Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes. Cell 32:227-238
4. Glass CK 1994 Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocr Rev 15:391-407
5. Umesono K, Evans RM 1989 Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139-1146
6. Sap J, Munoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennstrom B 1986 The c-erbA protein is a high affinity receptor for thyroid hormone. Nature 324:635-640
7. Sharif M, Privalsky ML 1991 V-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid. Cell 66:885-893
8. Damm K, Thompson CC, Evans RM 1989 Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 339:593-597
9. Zechel C, Shen X, Chen J, Chen Z, Chambon P, Gronemeyer H 1994 The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO J 13:1425-1433
10. Perlmann T, Rangarajan P, Umesono K, Evans RM 1993 Determinants for selective RAR and TR recognition of direct repeat HREs. Genes Dev 7:1411-1422
11. Umesono K, Murakami KK, Thompson CC, Evans RM 1991 Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65:1255-1266
12. Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM 1991 A direct repeat in the cellular retinol-binding protein type II confers differential regulation by RXR and RAR. Cell 66:555-561
13. Yen PM, Ikeda M, Brubaker JH, Forgione M, Sugawara A, Chin WW 1994 Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA. J Biol Chem 269:903-909
14. Subauste JS, Koenig RJ 1995 Comparison of the DNA binding specificity and function of v-erbA and thyroid hormone receptor α1. J Biol Chem 270:7957-7962
15. Koenig RJ, Lazar MA, Hodin RA, Brent GA, Larsen PR, Chin WW, Moore DD 1989 Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature 337:659-661
16. Bikle DD 1992 Vitamin D: new actions, new analogs, new therapeutic potential. Endocr Rev 13:765-784
17. Chen H, Smit-McBride Z, Lewis S, Sharif M, Privalsky ML 1993 Nuclear hormone receptors involved in neoplasia: erbA exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain. Mol Cell Biol 13:2366-2376
18. Chen DJ, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
19. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass C, Rosenfeld M 1995 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404
20. Hermann T, Hoffmann B, Piedrafita FJ, Zhang X, Pfahl M 1993 V-erbA requires auxiliary proteins for dominant negative activity. Oncogene 8:55-65
21. Damm K, Evans RM 1993 Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor α. Proc Natl Acad Sci USA 90:10668-10672
22. Nagaya T, Madison LD, Jameson JL 1992 Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes. J Biol Chem 267:13014-13019
23. Kakizuka A, Miller WH, Umesono K, Warell RP, Frankel SR, Murty VV, Dimitrovsky E, Evans RM 1991 Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR α with a novel putative transcription factor. Cell 66:663-674
24. Hughes MR, Malloy PJ, Kieback DG, Kesterson RA, Pike JW, Feldman D, O'Malley BW 1988 Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242:1702-1705
25. Horowitz KB 1992 Cellular heterogeneity and mutant oestrogen receptors in hormone resistant breast cancers. Cancer Surv 14:41-54
26. Katz RW, Koenig RJ 1993 Nonbiased identification of DNA sequences that bind thyroid hormone receptor α1 with high affinity. J Biol Chem 268:19392-19397
27. Subauste JS, Katz RW, Koenig RJ 1994 DNA binding specificity and function of retinoid X receptor α. J Biol Chem 269:30232-30237
28. Prost E, Koenig RJ, Moore DD, Larsen PR, Whalen RG 1988 Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries. Nucleic Acids Res 16:6248
29. Prost E, Moore DD 1986 CAT vectors for analysis of eukaryotic promoters and enhancers. Gene 45:107-111
30. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds) 1994 Current Protocols in Molecular Biology. John Wiley & Sons, New York, pp 12.3.1-12.3.7
31. Pu WT, Struhl K 1992 Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res 20:771-775
32. Koenig RJ, Wame RL, Brent GA, Harney JW, Larsen PR, Moore DD 1988 Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci USA 85:5031-5035
33. Thompson CC, Evans RM 1989 Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors. Proc Natl Acad Sci USA 86:3494-3498