Lipofection indirectly increases expression of endogenous major histocompatibility complex class I molecules on tumor cells

Cancer Gene Therapy

Volumn 5, Issue 5, 1998, Pages 307-312

  Fox, Bernard A ^a,b   Drury, Marcie ^a   Hu, Hong Ming ^a,b   Cao, Zhuwei ^a   Huntzicker, Erik G ^a   Qie, Wenxia ^a,b   Urba, Walter J ^a,b  

^a EARLE A CHILES RESEARCH INSTITUTE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Gene transfer; Immunotherapy; Lipofection; MHC class I; Tumor vaccines

Indexed keywords

DNA; H 2K(K) ANTIGEN; H 2KB PROTEIN, MOUSE; H-2K(K) ANTIGEN; H-2KB PROTEIN, MOUSE; H2 ANTIGEN; HISTOCOMPATIBILITY ANTIGEN H 2D(B); HISTOCOMPATIBILITY ANTIGEN H-2D(B); HLA ANTIGEN CLASS 1; LIPID; LIPOPOLYSACCHARIDE;

ANIMAL; ARTICLE; CELL CULTURE; CHEMISTRY; DRUG EFFECT; GENE TRANSFER; GENETICS; MELANOMA; METABOLISM; MOUSE; TIME; UPREGULATION;

ANIMALS; DNA; GENE TRANSFER TECHNIQUES; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; LIPIDS; LIPOPOLYSACCHARIDES; MELANOMA; MICE; TIME FACTORS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0032152333     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Roth JA, Cristiano RJ. Gene therapy for cancer: what have we done and where are we going? J Natl Cancer Inst. 1997;89:21-39.
2. Plautz GE, Yang ZY, Wu BY, et al. Immunotherapy of malignancy by in vivo gene transfer into tumors [see comments]. Proc Natl Acad Sci USA. 1993;90:4645-4649.
3. Nabel GJ, Nabel EG, Yang ZY, et al. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci USA. 1993;90:11307-11311.
4. Wahl WL, Plautz GE, Fox BA, et al. Generation of therapeutic T lymphocytes after in vivo transfection of a tumor with a gene encoding allogeneic class I major histocompatability complex antigen. Surg Forum. 1992:476-478.
5. Wahl W, Strome S, Nabel G, et al. Generation of therapeutic T-lymphocytes after in vivo tumor transfection with an allogeneic class I major histocompatibility complex gene. J Immunother Emphas Tumor Immunol. 1995;17:1-11.
6. Zabner J, Fasbender AJ. Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem. 1995;270: 18997-19007.
7. Hart IR. The selection and characterization of an invasive variant of the B16 melanoma. Am J Pathol. 1979;97:587-600.
8. Rivoltini L, Barracchini KC, Viggiano V, et al. Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes. Cancer Res. 1995;55:3149-3157.
9. Restifo NP, Kawakami Y, Marincola F, et al. Molecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I. J Immunother. 1993;14:182-190.
10. Weber JS, and Jay G. MHC class I gene expression by tumors: immuno-therapeutic implications [Review]. Curr Top Microbiol Immimol. 1988;137:140-147.
11. Cordon-Cardo C, Fuks Z, Drobnjak M, et al. Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas. Cancer Res. 1991; 51:6372-6380.
12. Weber JS, Jay G, Tanaka K, et al. Immunotherapy of a murine tumor with interleukin 2: increased sensitivity after MHC class I gene transfection. J Exp Med. 1987;166:1716-1733.
13. Der SD, Lau AS. Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity. Proc Natl Acad Sci USA. 1995;92:8841-8845.
14. Samuel CE, Kuhen KL, George CX, et al. The PKR protein kinase-an interferon-inducible regulator of cell growth and differentiation. Int J Hematol. 1997;65:227-237.
15. Wong AH, Tam NW, Yang YL, et al. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and doublestranded RNA signaling pathways. EMBO J. 1997;16: 1291-1304.
16. Meurs E. Tumor suppressor function of the interferoninduced double-stranded RNA-activated protein kinase. Proc Natl Acad Sci USA. 1993;90:232-236.
17. + T cells against the wild-type tumor: correlation with antigen presentation capability. J Exp Med. 1992;175:1423-1431.
18. Andrews JM, Newbound GC, Lairmore MD. Transcriptional modulation of viral reporter gene constructs following induction of the cellular stress response. Nucleic Acids Res. 1997;25:1082-1084.
19. Becker J, Craig EA. Heat-shock proteins as molecular chaperones. Eur J Biochem. 1994;219:11-23.
20. Srivastava PK, Udono H, Blachere NE, et al. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics. 1994;39:93-98.
21. Wells AD, Rai SK, Salvato MS, et al. Restoration of MHC class I surface expression and endogenous antigen presentation by a molecular chaperone. Scand J Immunol 1997; 45:605-612.
22. Shevach EM. Accessory Molecules. In: Paul WE, ed. Fundamental Immunology. 3rd Ed. New York: Raven Press;1993:531-575.
23. Pandolfi F, Trentin L, Boyle LA, et al. Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor-infiltrating lymphocytes. Cancer. 1992;69:1165-1173.