XVI. The Pneumocystis carinii major surface glycoprotein (MSG): Its potential involvement in the pathophysiology of pneumocystosis

FEMS Immunology and Medical Microbiology

Volumn 22, Issue 1-2, 1998, Pages 129-134

  Benfield, Thomas L ^a   Lundgren, Jens D ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Glycoprotein; Pathophysiology; Pneumocystis carinii

Indexed keywords

GLYCOPROTEIN; MEMBRANE PROTEIN; FUNGAL PROTEIN; FUNGUS ANTIGEN; GPA PROTEIN, PNEUMOCYSTIS CARINII SP.; LUNG SURFACTANT;

ANTIGENIC VARIATION; CONFERENCE PAPER; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS PNEUMONIA; PNEUMOCYSTOSIS; PRIORITY JOURNAL; ANIMAL; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; ANTIGENIC VARIATION; ANTIGENS, FUNGAL; FUNGAL PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; PNEUMONIA, PNEUMOCYSTIS; PULMONARY SURFACTANTS;

EID: 0032148375     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(98)00070-4     Document Type: Conference Paper

References (48)

1. Lundgren, B. (1994) Pneumocystis carinii: antigenic, immunological, and molecular characterization. Dan. Med. Bull. 41, 306-318.
2. Garbe, T.R. and Stringer, J.R. (1994) Molecular characterization of clustered variants of genes encoding major surface antigens of human Pneumocystis carinii. Infect. Immun. 62, 3092-3101.
3. Kovacs, J.A., Powell, F., Edman, J.C., Lundgren, B., Martinez, A., Drew, B. and Angus, C.W. (1993) Multiple genes encode the major surface glycoprotein of Pneumocystis carinii. J. Biol. Chem. 268, 6034-6040.
4. Kovacs, J.A., Halpern, J.L., Lundgren, B., Swan, J.C., Parillo, J.E. and Masur, H. (1989) Monoclonal antibodies to Pneumocystis carinii: Identification of specific antigens and characterization of antigenic differences between rat and human isolates. J. Infect. Dis. 159, 60-70.
5. Walzer, P.D. and Linke, M.J. (1987) A comparison of the antigenic characteristics of rat and human Pneumocystis carinii by immunoblotting. J. Immunol. 138, 2257-2265.
6. Linder, E., Lundin, L. and Vorma, H. (1987) Detection of Pneumocystis carinii in lung-derived samples using monoclonal antibodies to an 82 kDa parasite component. J. Immunol. Methods 98, 57-62.
7. Walzer, P.D., Stanforth, D., Linke, M.J. and Cushion, M.T. (1987) Pneumocystis carinii: immunoblotting and immunofluorescent analyses of serum antibodies during experimental rat infection and recovery. Exp. Parasitol. 63, 319-328.
8. Graves, D.C., McNabb, S.J., Worley, M.A., Downs, T.D. and Ivey, M.H. (1986) Analyses of rat Pneumocystis carinii antigens recognized by human and rat antibodies by using western immunoblotting. Infect. Immun. 54, 96-103.
9. Gigliotti, F., Ballou, L.R., Hughes, W.T. and Mosley, B.D. (1988) Purification and initial characterization of a ferret Pneumocystis carinii surface antigen. J. Infect. Dis. 158, 848-854.
10. Lipschik, G.Y., Treml, J.F., Moore, S.D. and Beers, M.F. (1998) Pneumocystis carinii glycoprotein A inhibits surfactant phospholipid secretion by rat alveolar type II cells. J. Infect. Dis. 177(1), 182-187.
11. Lundgren, B., Lipschik, G.Y. and Kovacs, J.A. (1991) Purification and characterization of a major human Pneumocystis carinii surface antigen. J. Clin. Invest. 87, 163-170.
12. Kitamura, K. and Yamamura, Y. (1972) Purification and properties of an enzyme, zymolyase, which lyses viable yeast cells. Arch. Biochem. Biophys. 153, 403-406.
13. De Stefano, J.A., Cushion, M.T., Sleight, R.G. and Walzer, P.D. (1990) Analysis of Pneumocystis carinii cyst wall. I. Evidence for an outer surface membrane. J. Protozool. 37, 428-435.
14. Benfield, T.L., Prentø, P., Junge, J., Vestbo, J. and Lundgren, J.D. (1997) Alveolar damage in AIDS-associated Pneumocystis carinii pneumonia. Chest 111, 1193-1197.
15. Limper, A.H. and Martin, W.J. II (1990) Pneumocystis carinii: inhibition of lung cell growth mediated by parasite attachment. J. Clin. Invest. 85, 391-396.
16. Pottratz, S.T. and Martin, W.J. II (1990) Role of fibronectin in Pneumocystis carinii attachment to cultured lung cells. J. Clin. Invest. 85, 351-356.
17. Limper, A.H., Standing, J.E., Hoffman, O.A., Castro, M. and Neese, L.W. (1993) Vitronectin binds to Pneumocystis carinii and mediates organism attachment to cultured lung epithelial cells. Infect. Immun. 61, 4302-4309.
18. Pottratz, S.T., Paulsrud, J., Smith, J.S. and Martin, W.J. II (1991) Pneumocystis carinii attachment to cultured lung cells by pneumocystis gp 120, a fibronectin binding protein. J. Clin. Invest. 88, 403-407.
19. Pottratz, S.T., Weir, A.L. and Wisniowski, P.E. (1994) Pneumocystis carinii attachment increases expression of fibronectin-binding integrins on cultured lung cells. Infect. Immun. 62, 5464-5469.
20. Zimmerman, P.E., Voelker, D.R., McCormack, F.X., Paulsrud, J.R. and Martin, W.J. I (1992) 120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A. J. Clin. Invest. 89, 143-149.
21. O'Riordan, D.M., Standing, J.E., Kwon, K.Y., Chang, D., Crouch, E.C. and Limper, A.H. (1995) Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages. J. Clin. Invest. 95, 2699-2710.
22. Masur, H. and Jones, T.C. (1978) The interaction in vitro of Pneumocystis carinii with macrophages and L-cells. J. Exp. Med. 147, 157-170.
23. O'Riordan, D.M., Standing, J.E. and Limper, A.H. (1995) Pneumocystis carinii glycoprotein A binds macrophage mannose receptors. Infect. Immun. 63, 779-784.
24. Peglow, S.L., Smulian, S.L. and Linke, M.J. (1990) Serologic responses to Pneumocystis carinii antigens in health and disease. J. Infect. Dis. 161, 296-306.
25. Lundgren, B., Lebech, M., Lind, K., Nielsen, J.O. and Lundgren, J.D. (1993) Antibody response to a major human Pneumocystis carinii surface antigen in patients without evidence of immunosuppression and in patients with suspected atypical pneumonia. Eur. J. Clin. Microbiol. Infect. Dis. 12, 105-109.
26. Lundgren, B., Lundgren, J.D., Nielsen, T., Mathiesen, L., Nielsen, J.O. and Kovacs, J.A. (1992) Antibody responses to a major Pneumocystis carinii antigen in human immunodeficiency virus-infected patients with and without P. carinii pneumonia. J. Infect. Dis. 165, 1151-1155.
27. Lundgren, B., Kovacs, J.A., Mathiesen, L., Nielsen, J.O. and Lundgren, J.D. (1993) IgM response to a human Pneumocystis carinii surface antigen in HIV-infected patients with pulmonary symptoms. Scand. J. Infect. Dis. 25, 515-520.
28. Gigliotti, F. and Harmsen, A. (1997) Pneumocystis carinii host origin defines the antibody specificity and protective response induced by immunization. J. Infect. Dis. 176, 1322-1326.
29. Gigliotti, F. and Hughes, W.T. (1988) Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonitis in animal models. J. Clin. Invest. 81, 1666-1668.
30. Theus, S.A., Linke, M.J., Andrews, R.P. and Walzer, P.D. (1993) Proliferative and cytokine responses to a major surface glycoprotein of Pneumocystis carinii. Infect. Immun. 61, 4703-4709.
31. Theus, S.A., Sawhney, N. Smulian, A.G. and Walzer, P.D. (1998) Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii. J. Infect. Dis. 177, 238-241.
32. Theus, S.A., Andrews, R.P., Steele, P. and Walzer, P.D. (1995) Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat. J. Clin. Invest. 95, 2587-2593.
33. Benfield, T.L., Lundgren, B., Levine, S.J., Kronborg, G., Shelhamer, J.H. and Lundgren, J.D. (1997) The major surface glycoprotein of Pneumocystis carinii induces release and gene expression of interleukin-8 and tumor necrosis factor alpha in monocytes. Infect. Immun. 65, 4790-4794.
34. Ezekowitz, R.A.B., Williams, D.J., Koziel, H., Armstrong, M.Y.K., Warner, A., Richards, F.F. and Rose, R.M. (1991) Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor. Nature 351, 155-158.
35. Kandil, O., Fishman, J.A., Koziel, H., Pinkston, P., Rose, R.M. and Remold, H.G. (1994) Human immunodeficiency virus type 1 infection of human macrophages modulates the cytokine response to Pneumocystis carinii. Infect. Immun. 62, 644-650.
36. Benfield, T.L., Lundgren, B., Lundgren, J.D. and Shelhamer, J.H. (1996) MSG of P. carinii induces gene expression and secretion of IL-6 and 8 in alveolar epithelium. Am. J. Respir. Crit. Care Med. 153, A695.
37. Hoffman, A.G.D., Lawrence, M., Ognibene, F.P., Suffredini, A.F., Lipschik, G.Y., Kovacs, J.A., Masur, H. and Shelhamer, J.H. (1992) Reduction of pulmonary surfactant in patients with human immunodeficiency virus infection and Pneumocystis carinii pneumonia. Chest 102, 1730-1736.
38. Dichter, J.R., Lundgren, J.D., Nielsen, T.L., Jensen, B.N., Schattenkerk, J.K.M.E., Benfield, T.L., Lawrence, M. and Shelhamer, J.H. (1998) Pneumocystis carinii pneumonia in HIV infected patients: effect of steroid therapy on surfactant level (in press).
39. Rice, W., Singleton, F., Linke, M.J. and Walzer, P.D. (1993) Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. J. Clin. Invest. 92, 2778-2782.
40. Masur, H., Meier, P. and McCutchan, J.A. (1990) Consensus statement on the use of corticosteroids as adjunctive therapy for Pneumocystis pneumonia in the acquired immunodeficiency syndrome. New Engl. J. Med. 323, 1500-1504.
41. Bozzette, S.A. and Morton, S.C. (1995) Reconsidering the use of adjunctive corticosteroids in Pneumocystis pneumonia? J. AIDS 8, 345-347.
42. Kales, C.P., Murren, J.R., Torres, R.A. and Crocco, J.A. (1987) Early predictors of in-hospital mortality for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Arch. Intern. Med. 147, 1413-1417.
43. Mason, G.R., Hashimoto, C.H., Dickman, P.S., Foutty, L.F. and Cobb, C.J. (1989) Prognostic implications of bronchoalveolar lavage neutrophilia in patients with Pneumocystis carinii pneumonia and AIDS. Am. Rev. Respir. Dis. 139, 1336-1342.
44. Brenner, M., Ognibene, F.P., Lack, E.E., Simmons, J.T., Suffredini, A.F., Lane, H.C., Fauci, A.S., Parillo, J.E., Shelhamer, J.H. and Masur, H. (1987) Prognostic factors and life expectancy of patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. Am. Rev. Respir. Dis. 136, 1199-1203.
45. Zaman, M.K. and White, D.A. (1988) Serum lactate dehydrogenase levels and Pneumocystis carinii pneumonia. Am. Rev. Respir. Dis. 137, 796-800.
46. Benfield, T.L., Vestbo, J., Junge, J., Nielsen, T.L., Jensen, A.B. and Lundgren, J.D. (1995) Prognostic value of interleukin-8 in AIDS-associated Pneumocystis carinii pneumonia. Am. J. Respir. Crit. Care Med. 151, 1058-1062.
47. Bendtsen, K.D., Nielsen, T.L., Schattenkerk, J.M.E., Jensen, B.N. and Lundgren, J.D. (1993) Type III procollagen in serum as marker of disease activity and prognosis in patients with Pneumocystis carinii infection. Am. Rev. Respir. Dis. 148, 490-494.
48. Benfield, T.L., Schattenkerk, J.K., Hofmann, B., Jensen, B.N., Nielsen, T.L. and Lundgren, J.D. (1994) Differential effect on serum neopterin and serum beta 2-microglobulin is induced by treatment in Pneumocystis carinii pneumonia. J. Infect. Dis. 169, 1170-1173.