The murine Fhit locus: Isolation, characterization, and expression in normal and tumor cells

Cancer Research

Volumn 58, Issue 15, 1998, Pages 3401-3408

  Pekarsky, Yuri ^a   Druck, Teresa ^a   Cotticelli, Maria Grazia ^a   Ohta, Masataka ^a,c   Shou, Jiang ^a   Mendrola, Jeannine ^a   Montgomery, Jeffry C ^a   Buchberg, Arthur M ^a   Siracusa, Linda D ^a   Manenti, Giacomo ^b   Fong, Louise Y Y ^a   Dragani, Tommaso A ^b   Croce, Carlo M ^a   Huebner, Kay ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CHROMOSOME 3P; GENE DELETION; GENE ISOLATION; GENE LOCUS; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; DNA, COMPLEMENTARY; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTEIN BIOSYNTHESIS; PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0032146785     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Ohta, M., Inoue, H., Cotticelli, M. G., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, M., McCue, P., Druck, T., Croce, C. M., and Huebner, K. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell, 84: 587-597, 1996.
2. Druck, T., Hadaczek, P., Fu, T-B., Ohta, M., Siprashvili, Z., Baffa, R., Negrini, M., Kastury, K., Veronese, M. L., Rosen, D., Rothstein, J., McCue, P., Cotticelli, M. G., Inoue, H., Croce, C. M., and Huebner, K. Structure and expression of the human FHIT gene in normal and tumor cells. Cancer Res., 57: 504-512, 1997.
3. Inoue, H., Ishii, H., Alder, H., Snyder, E., Druck, T., Huebner, K., and Croce, C. M. Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion. Proc. Natl. Acad. Sci. USA, 94: 14584-14589, 1997.
4. Virgilio, L., Schuster, M., Gollin, S. M., Veronese, M. L., Ohta, M., Huebner, K., and Croce, C. M. FHIT gene alterations in head and neck squamous cell carcinomas. Proc. Natl. Acad. Sci. USA, 93: 9770-9775, 1996.
5. Michael, D., Beer, D. G., Wilke, C. W., Miller, D. E., and Glover, T. W. Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas. Oncogene, 15: 1553-1559, 1997.
6. Sozzi, G., Veronese, M. L., Negrini, M., Baffa, R., Cotticelli, M. G., Inoue, H., Tornielli, S., Pilotti, S., DeGregorio, L., Pastorino, V., Pierotti, M. A., Ohta, M., Huebner, K., and Croce, C. M. The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell, 85: 17-26, 1996.
7. Greenspan, D. L., Connolly, D. C, Wu, R., Lei, R. Y., Vogelstein, J. T. C., Kim, Y-T., Mok, J. E., Munoz, N., Bosch, X., Shah, K., and Cho, K. R. Loss of FHIT expression in cervical carcinoma cell lines and primary tumors. Cancer Res., 57: 4692-4698, 1997.
8. Gemma, A., Hagiwara, K., Ke, Y., Burke, L. M., Khan, M. A., Nagashima, M., Bennett, W. P., and Harris, C. C. FHIT mutations in human primary gastric cancer. Cancer Res., 57: 1435-1437, 1997.
9. Panagopoulos, I., Thelin, S., Mertens, F., Mitelman, F., and Aman, P. Variable FHIT transcripts in non-neoplastic tissues. Genes Chromosomes Cancer, 19: 215-219, 1997.
10. van den Berg, A., Draaijers, T. G., Kok, K., Timmer, T., Van der Veen, A. Y., Veldhuis, P. M. J. F., de Leij, L., Gerhartz, C. D., Naylor, S. L., Smith, D. I., and Buys, C. H. C. M. Normal FHIT transcripts in renal cell cancer- and lung cancer-derived cell lines, including a cell line with a homozygous deletion in the FRA3B region. Genes Chromosomes Cancer, 19: 220-227, 1997.
11. Siprashvili, Z., Sozzi, G., Barnes, L. D., McCue, P., Robinson, A. K., Eryomin, V., Sard, L., Tagliabue, E., Greco, A., Fusetti, L., Schwartz, G., Pierotti, M. A., Croce, C. M., and Huebner, K. Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc. Natl. Acad. Sci. USA, 94: 13771-13776, 1997.
12. Otterson, G. A., Xiao, G-H., Geradts, J., Jin, F., Chen, W., Niklinska, W., Kaye, F. J., and Yeung, R. S. Protein expression and functional analysis of the FHIT gene in human tumor cells. J. Natl. Cancer Inst. (Bethesda), 90: 426-432, 1998.
13. Sozzi, G., Tornielli, S., Tagliabue, E., Sard, L., Pezzella, F., Pastorino, U., Minoletti, F., Pilotti, S., Ratcliffe, C., Veronese, M. L., Goldstraw, P., Huebner, K., Croce, C. M., and Pierotti, M. A. Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities. Cancer Res., 57: 5207-5212, 1997.
14. Xiao, G-H., Jin, F., Klein-Szanto, A. J. P., Goodrow, T. L., Linehan, M. W., and Yeung, R. S. The FHIT gene product is highly expressed in the cytoplasm of renal tubular epithelium and is down-regulated in kidney cancers. Am. J. Pathol., 151: 1541-1547, 1997.
15. Mao, L., Lee, J. S., Kurie, J. M., Fan, Y. H., Lippman, S. M., Lee, J. J., Ro, J. Y., Broxson, A., Yu, R., Morice, R. C., Kemp, B. L., Khuri, F. R., Walsh, G. L., Hittelman, W. N., and Hong, W. K. Clonal genetic alterations in the lungs of current and former smokers. J. Natl. Cancer Inst. (Bethesda), 89: 857-862, 1997.
16. Wistuba, I. I., Lam, S., Behrens, C., Virmani, A. K., Fong, K. M., LeRiche, J., Samet, J. M., Srivastava, S., Minna, J. D., and Gazdar, A. F. Molecular damage in the bronchial epithelium of current and former smokers. J. Natl. Cancer Inst. (Bethesda), 89: 1366-1373, 1997.
17. Yunis, J. J., and Soreng, A. L. Constitutive fragile sites and cancers. Science (Washington DC), 226: 1199-1204, 1984.
18. Mao, L. Tumor suppressor genes: does FHIT fit? J. Natl. Cancer Inst. (Bethesda), 90: 412-414, 1998.
19. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual, Ed. 2. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
20. Marini, J. C., Nelson, K. K., Battey, J., and Siracusa, L. D. The pituitary hormones arginine vasopressin-neurophysin II and oxytocin-neurophysin I show close linkage with interleukin-1 on mouse chromosome 2. Genomics, 15: 200-202, 1993.
21. Wary, K., Lou, Z., Buchberg, A., Siracusa, L., Druck, T., LaForgia, S., and Huebner, K. A homozygous deletion in the carbonic anhydrase-like domain of the Ptpg gene in murine L cells. Cancer Res., 53: 1498-1502, 1993.
22. Canzian, P., Gariboldi, M., Manenti, G., De Gregorio, L., Osada, S., Ohno, S., Dragani, T. A., and Pierotti, M. A. Expression in lung tumors and genetic mapping of the murine protein kinase Cn (nPKCn). Mol. Carcinog., 9: 111-113, 1994.
23. Dragani, T. A., Falvella, F. S., Manenti, G., Pierotti, M. A., and Gambetta, R. A. Downexpression of aldehyde dehydrogenase 1 in murine lung tumors. Mol. Carcinog., 16: 123-125, 1996.
24. Pathak, S., Dave, B. J., and Gadhia, P. K. Mouse chromosome 14 is altered in different metastatic murine neoplasias. Cancer Genet. Cytogenet., 83: 172-173, 1995.
25. Williams, R. F., Pekarsky, Y., Cheng, S., and Gardiner, K. YAC clones targeting gene-rich regions of human chromosome 3. Mamm. Genome, 5: 380-383, 1994.
26. Dragani, T. A., Manenti, G., and Della Porta, G. Quantitative analysis of genetic susceptibility to liver and lung carcinogenesis in mice. Cancer Res., 51: 6299-6303, 1991.
27. Gariboldi, M., Manenti, G., Canzian, P., Falvella, F. S., Radice, M. T., Pierotti, M. A., Della Porta, G., Binelli, G., and Dragani, T. A. A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6. Nat. Genet. 3: 132-136, 1993.
28. Kastury, K., Ohta, M., Lasota, J., Moir, D., Dorman, T., LaForgia, S., Druck, T., and Huebner, K. Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. Genomics 32: 225-235, 1996.
29. Zimonjic, D. B., Druck, T., Ohta, M., Kastury, K., Popescu, N. C., and Huebner, K. Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene. Cancer Res. 57: 1166-1170, 1997.
30. Glover, T. W., Hoge, A., Miller, D. E., Askara-Wilke, J., Wilke, C. M., Adam, A., Dagenais, S. L., Dierick, H. A., and Beer, D. G. The murine FHIT gene is highly similar to its human orthologue and maps to a common fragile site region. Cancer Res., 58: 3409-3414, 1998.