Developments toward large-scale bacterial bioprocesses in the presence of bulk amounts of organic solvents

Extremophiles

Volumn 2, Issue 3, 1998, Pages 249-256

  Schmid, Andrew ^a,b   Kollmer, Andreas ^a,d   Mathys, Renata G ^a   Witholt, Bernard ^a,c  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c Schneider Europe AG   (Switzerland)

^d Rieter Group   (Switzerland)

Author keywords

Alkanes; Biotransformation; Explosion hazard; High pressure; Pseudomonas oleovorans; Safety; Two liquid phase culture

Indexed keywords

AQUEOUS SOLUTION; BIOCATALYST; BIOREACTOR; BIOTRANSFORMATION; CULTURE MEDIUM; FERMENTATION; OXIDATION; SOLVENT;

BACTERIA; BIOREACTORS; BIOTECHNOLOGY; BIOTRANSFORMATION; EXPLOSIONS; OXIDATION-REDUCTION; OXYGEN; PILOT PROJECTS; PRESSURE; PSEUDOMONAS; SAFETY; SOLVENTS;

BACTERIA (MICROORGANISMS); PSEUDOMONAS; PSEUDOMONAS OLEOVORANS;

EID: 0032143815     PISSN: 14310651     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007920050067     Document Type: Review

References (40)

1. Bosetti A, van Beilen JB, Preusting H, Lageveen RG, Witholt B (1992) Production of primary aliphatic alcohols with a recombinant Pseudomonas strain, encoding the alkane-hydroxylase enzyme system. Enzyme Microb Technol 14:702-708
2. Collins AM, Woodley JM, Liddell JM (1995) Determination of reactor operation for the microbial hydroxylation of toluene in a two-liquid phase process. J Ind Microbiol 14:382-388
3. de Smet MJ (1982) A biotechnological approach to the synthesis of epoxides. PhD thesis, Rijksuniversiteit te Groningen, Netherlands
4. de Smet MJ, Kingma J, Wynberg H, Witholt B (1983) Pseudomonas oleovorans as a tool in bioconversions of hydrocarbons: growth, morphology and conversion characteristics in different two-phase systems. Enzyme Microb Technol 5:352-360
5. ESCIS (Expertenkommission für Sicherheit in der chemischen Industrie der Schweiz) (1992) Inertisierung; Methoden und Mittel zum Vermeiden zündfähiger Stoff-Luft-Gemische in chemischen Produktionsapparaturen und -anlagen. Heft 3, Basel
6. Faber K (1997) Biotransformations in organic chemistry. Springer, Berlin
7. Favre Bulle O, Witholt B (1992) Biooxidation of n-octane by a recombinant Escherichia coli in a two-liquid-phase system: effect of medium components on cell growth and alkane oxidation activity. Enzyme Microb Technol 14:931-937
8. Favre Bulle O, Weenink E, Vos T, Preusting H, Witholt B (1993) Continuous bioconversion of n-octane to octanoic acid by recombinant Escherichia coli (alk+) growing in a two-liquid-phase chemostat. Biotechnol Bioeng 41:263-272
9. Furuhashi K, Shintani M, Takagi M (1986) Effects of solvents on the production of cpoxides by Nocardia corallina B-276. Appl Microbiol Biotechnol 23:218-223
10. Goswami P, Singh HD (1991) Different modes of hydrocarbon uptake by two Pseudomonas species. Biotechnol Bioeng 37:1-11
11. Harayama S, Rekik M, Wubbolts MG, Rose K, Leppik R, Timmis KN (1989) Characterization of five genes in the upper-pathway operon of TOL plasmid pWWO from Pseudomonas putida and identification of the gene products. J Bacteriol 171:5048-5055
12. Hazenberg WM (1997) Production of poly(3-hydroxyalkanoates) by Pseudomonas oleovorans in two-liquid phase media. PhD thesis, Eidgenösische Technische Hochschule. Zürich, Switzerland
13. Kawakami K, Nakahara T (1994) Importance of solute partitioning in biphasic oxidation of benzyl alcohol by free and immobilized whole cells of Pichia pastoris. Biotechnol Bioeng 43:918-924
14. Kollmer A (1997) Verfahrenstechnische Aspekte bei zwei-flüssigphasigen Bioprozessen. PhD thesis, Eidgenösische Technische Hochschule, Zürich, Switzerland
15. Kollmer A, Rudolf von Rohr P (1997) Sichere Prozessbedingungen bei leichtflüchtigen Kohlenwasserstoffen durch erhöhten Druck. Chem Ing Tech 69:681-685
16. Lageveen RG (1986) Oxidation of aliphatic compounds by Pseudomonas oleovorans. PhD thesis, Rijksuniversiteit te Groningen. Netherlands
17. Liu WH, Horng WC, Tsai MS (1996) Bioconversion of cholesterol to cholest-4-en-3-one in aqueous/organic solvent two-phase reactors. Enzymes Microb Technol 18:184-189
18. Mathys RG (1997) Bioconversion in two-liquid phase systems: downstream processing. PhD thesis, Eidgenösische Technische Hochschule, Zürich, Switzerland
19. Mathys RG, Heinzelmann W, Witholt B (1997) Separation of higher molecular weight organic compounds by pervaporation. Chem Eng J 67:191-197
20. Mathys RG, Kut OM, Witholt B (1998a) Alkanol removal from the apolar phase of a two-liquid fermentation system. 1. Comparison of a less volatile and a more volatile in situ extraction solvent for separation of 1-octanol by distillation. J Chem Technol Biotechnol 71:315-325
21. Mathys RG, Schmid A, Kut OM, Witholt B (1998b) Alkanol removal from the apolar phase of a two-liquid fermentation system. 2. Effect of fermentation medium on distillation. J Chem Technol Biotechnol 71:326-334
22. McKenna EJ, Coon MJ (1970) Enzymatic ω-oxidation. IV. Purification and properties of the co-hydroxylase of Pseudomonas oleovorans. J Biol Chem 245:3882-3889
23. BM-3 gene. Mol Cell Biochem 79:63-71
24. Preusting H, Hazenberg W, Witholt B (1993) Continuous production of poly(3-hydroxyalkanoates) by Pseudomonas oleovorans in a highcell-density, two-liquid-phase chemostat. Enzyme Microb Technol 15:311-316
25. Preusting H, Kingma J, Witholt B (1991) Physiology and polyester formation of Pseudomonas oleovorans in continuous two-liquidphase cultures. Enzyme Microb Technol 13:770-780
26. Rosenberg M, Rosenberg E (1981) Role of adherence in growth of Acinetobacter calcoaceticus RAG-1 on hexadecane. J Bacteriol 148:51-57
27. Schmid A (1997) Two-liquid phase bioproccss development: interfacial mass transfer rates and explosion safety. PhD thesis. Eidgenössische Technische Hochschule, Zürich, Switzerland
28. Schmid A, Kollmer A, Witholt B (in press, a) Effects of biosurfactant and emulsification on two-liquid phase Pseudomonas oleovorans cultures and cell-free emulsions containing n-decane. Enzyme Microb Technol
29. Schmid A, Sonnleitner B, Witholt B (in press, b) Medium chain length alkane solvent-cell mass transfer rates in two-liquid phase, Pseudomonas oleovorans cultures. Biotechnol Bioeng
30. Schmid A, Kollmer A, Sonnleitner B, Witholt B (in press c) Development of equipment and procedures for the safe operation of aerobic bacterial bioprocesses in the presence of bulk amounts of flammable organic soluents. Bioprocess Eng
31. Staijen IE (1996) The alkane hydroxylase system of Pseudomonas oleovorans: expression and activity in recombinant Escherichia coli and the native host. PhD thesis, Eidgenösische Technische Hochschule. Zürich, Switzerland
32. Suske WA, Held M, Schmid A, Fleischmann T, Wubbolts MG, Kohler HPE (1997) Purification and characterization of 2-hydroxybiphenyl 3-monooxygenase, a novel NADH-dependent. FAD-containing aromatic hydroxylase from Pseudomonas azelaica HBP1. J Biol Chem 272:24257-24265
33. Tsai JT, Wahbi LP, Dervakos GA, Stephens GM (1996) Production of toluene cis-glycol by a recombinant Escherichia coli strain in a twoliquid phase culture system. Biotechnol Lett 18:241-244
34. van Beilen JB, Kingma J, Witholt B (1994a) Substrate specificity of the alkane hydroxylase system of Pseudomonas oleovorans Gpol. Enzyme Microb Technol 16:904-911
35. van Beilen JB. Wubbolts MG, Witholt B (1994b) Genetics of alkane oxidation by Pseudomonas oleovorans. Biodegradation 5:161-174
36. Witholt B, de Smet MJ, Kingma J, van Beilen JB, Kok M, Lageveen RG, Eggink G (1990) Bioconversions of aliphatic compounds by Pseudomonas oleovorans in multiphase bioreactors: background and economic potential. Tibtechnology 8:46-52.
37. Woodley JM, Brazier AJ, Lilly MD (1991) Lewis cell studies to determine reactor design data for two-liquid-phase bacterial and enzymic reactions. Biotechnol Bioeng 37:133-140
38. Wubbolts MG, Favre-Bulle O, Witholt B (1996) Biosynthesis of symhons in two-liquid-phase media. Biotechnol Bioeng 52:301-308
39. Wubbolts MG, Hoven J, Melgert B, Witholt B (1994a) Efficient production of optically active styrene epoxides in two-liquid phase cultures. Enzyme Microb Technol 16:887-894
40. Wubbolts MG. Reuvekamp P, Witholt B (1994b) TOL plasmid-specified xylene oxygenase is a wide substrate range monooxygenase capable of olefin epoxidation. Enzyme Microb Technol 16:608-615