ARA, a novel ABC transporter, is located at 16p13.1, Is deleted in inv(16) leukemias, and is shown to be expressed in primitive hematopoietic precursors

Genomics

Volumn 51, Issue 3, 1998, Pages 455-458

  Kuss, B J ^a   O'Neill, G M ^b   Eyre, H ^a   Doggett, N A ^c   Callen, D F ^a   Davey, R A ^b  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHROMOSOME 16P; CLINICAL ARTICLE; FEMALE; GENE DELETION; GENE MAPPING; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA; MALE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0032142981     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1998.5349     Document Type: Article

References (18)

1. r. Cancer Res. 55:1995;102-110.
2. Bellann-Chantelot C., Lacroix B., Ougen P., Billaut A., Beaufils S., Bertrand S., Georges I., Gilbert F., Gros I., Lucotte G., Susini L., Codani J. J., Gesnouin P., Pook S., Vaysseix G., Lu-Kuo J., Ried T., Ward D., Chumakov I., Le Paslier D., Barillot E., Cohen D. Mapping the whole human genome by fingerprinting yeast artificial chromosomes. Cell. 70:1992;1059-1068.
3. Callen D. F., Baker E., Eyre H. J., Chernos J. E., Bell J. A., Sutherland G. R. Reassessment of two apparent deletions of chromosome 16p to an ins(11;16) and a t(1;16) by chromosome painting. Ann. Genet. 33:1990;219-221.
4. Callen D. F., Lane S., Kozman H., Kremmidiotis G., Whitmore S. A., Lowenstein M., Doggett N. A., Kenmochi N., Page D. C., Maglott D. R., Nierman W. C., Murakawa K., Berry R., Sikela J. M., Houlgatte R., Auffray C., Sutherland G. R. Integration of transcript and genetic maps of chromosome 16 at near-1-Mb resolution: Demonstration of a hot spot for recombination at 16p12. Genomics. 29:1995;503-511.
5. Cole S. P., Bhardwaj G., Gerlach J. H., Mackie J. E., Grant C. E., Almquist K. C. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 258:1992;1650-1654.
6. Cole S. P. C., Sparks K. E., Fraser K., Loe D. W., Grant C. E., Wilson G. M. Pharmacological characterisation of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54:1994;5902-5910.
7. Dauwerse J. G., Wessels J. W., Giles R. H., Wiegant J., van der Reijden B. A., Fugazza G. Cloning the breakpoint cluster region of the inv(16) in acute nonlymphocytic leukemia M4Eo. Hum. Mol. Genet. 2:1993;1527-1534.
8. Doggett N. A., Goodwin L. A., Tesmer J. G., Meincke L. J., Bruce D. C., Clark L. M., Altherr M. R., Ford A. A., Chi H. C., Marrone B. L., Longmire J. L., Lane S. A., Whitmore S. A., Lowenstein M. G., Sutherland R. D., Mundt M. O., Knill E. H., Bruno W. J., Macken C. A., Torney D. C., Wu J. R., Griffith J., Sutherland G. R., Deaven L. L., Callen D. F., Moyzis R. K. An integrated physical map of human chromosome 16. Nature. 377:1995;335-339.
9. Grant C. E., Valdimarsson G., Hipfner D. R., Almquist K. C., Cole S. P. C., Deeley R. G. Overexpression of multidrug resistance associated protein (MRP) increases resistance to natural product drugs. Cancer Res. 54:1994;357-361.
10. Hipfner D. R., Almquist K. C., Stride B. D., Deeley R. G., Cole S. P. C. Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1. Cancer Res. 56:1996;3307-3314.
11. Keppler D., Konig J. Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/MOAT) gene in liver. FASEB J. 11:1997;509-516.
12. Klughbauer N., Hofmann F. Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance associated protein. FEBS Lett. 391:1996;61-65.
13. Kool M., de Haas M., Scheffer G., Scheper R., van Eijk M., Juijn J., Baas F., Borst P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5 homologues of multidrug resistance-associated protein gene (MRP1) in human cancer cell lines. Cancer Res. 57:1997.
14. Kuss B., Deeley R., Cole S., Willman C., Kopecky K., Wolman S., Eyre H. J., Lane S. A., Nancarrow J., Whitmore S. A., Callen D. F. Deletion of the gene for multidrug resistance in acute myeloid leukaemia with the inversion chromosome 16: Prognostic implications. Lancet. 343:1994;1531-1534.
15. Kuss B. J., Deeley R. G., Cole S. P. C., Willman C. L., Kopecky K. J., Wolman S. R., Eyre H. J., Callen D. F. The biological significance if the multidrug resistance gene MRP in inversion 16 leukaemias. Leukemia Lymphoma. 20:1996;357-364.
16. Liu P. P., Tarle S. A., Hajra A., Claxton D. F., Marlton P., Freedman M., Siciliano M. J. Fusion between a transcription factor CBFβ and a myosin heavy chain gene (MYH11). Science. 261:1993;1041-1044.
17. Longhurst T. J., O'Neill G. M., Harvie R. M., Davey R. A. The Anthracycline Resistance Associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line. Br. J. Cancer. 74:1996;1331-1335.
18. Marlton P., Claxton D. F., Liu P., Estey E., Beran M., LeBeau M. Molecular charaterization of 16p deletions associated with inversion 16 defines the critical fusion for leukaemogenesis. Blood. 85:1995;772-779.