Potential antitumor α-methylene-γ-butyrolactone-bearing nucleic acid base. 3. Synthesis of 5′-methyl-5′-[(6-substituted-9H-purin-9-yl)methyl]-2′-oxo- 3′-methylenetetrahydrofurans

Archives of Pharmacal Research

Volumn 21, Issue 4, 1998, Pages 458-464

  Kim, Jack C ^a   Kim, Si Hwan ^a   Kim, Ji A ^a   Choi, Soon Kyu ^b   Park, Won Woo ^c  

^a Pusan National University   (South Korea)

^b Dong A University   (South Korea)

^c Pusan Junior College   (South Korea)

Author keywords

5 Methyl 5 (6 substituted 9H purin 9 yl)methyl 2 oxo 3 methylenetetrahydrofuran; 6 Substituted 9H purin 9 yl 2 propanone; Antitumor activity; Cytotoxic moiety; IC50; Reformatsky reaction

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; PURINE DERIVATIVE;

ANIMAL; ARTICLE; CELL CULTURE; CHEMISTRY; DRUG SCREENING; HUMAN; MOUSE; SYNTHESIS;

4-BUTYROLACTONE; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; PURINES; TUMOR CELLS, CULTURED;

EID: 0032130672     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02974643     Document Type: Article

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