Studies on the effects of piperidine derivatives on blood pressure and smooth muscles contractions

Archives of Pharmacal Research

Volumn 21, Issue 4, 1998, Pages 370-373

  Saeed, M ^a   Saify, Z S ^b   Gilani, A H ^c   Iqbal, Z ^a  

^a UNIVERSITY OF PESHAWAR   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

Author keywords

Antihypertensive; Piperidine; Smooth muscle contraction

Indexed keywords

PIPERIDINE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD PRESSURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; FEMALE; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; JEJUNUM; MALE; MUSCLE CONTRACTION; PHYSIOLOGY; RABBIT; RAT; SMOOTH MUSCLE; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, INTRAVENOUS; JEJUNUM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERIDINES; RABBITS; RATS; RATS, WISTAR;

EID: 0032130334     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02974628     Document Type: Article

References (16)

1. Archibald, J. L., Baum, T. and Childress, S. J., 1,4-Bis (2-indol-3-ylethyl)piperidines. J. Med Chem., 13, 138-40 (1970).
2. Bolton, T. B., Mechanism of action of transmitters and other substances on smooth muscles. Physiol. Rev., 59, 606-718 (1979).
3. Brading, A. F., TIPS., How do drugs initiate contraction in smooth muscles? 2, 259-61 (1981).
4. Clark, R. D., Caroon, J. M., Kluge, A. F. and Okada, M. D., Synthesis and antihypertensive activity of ′4-substituted spiro(4H-3,1-benzoxazine-4,′4-piperidine)-2(1H)-ones. J. Med. Chem., 26, 657-61 (1983).
5. Gilani, A. H., Janbaz, K. H., Lateef, A. and Zaman, M., Calcium channel blocking activity of Artemisia scoparia extract. Phytother. Res., 8, 161-65 (1994).
6. Maillard, J., Delaunary, P., Langlois, M. and Vo Van, T., Spiro-heterocyclic cycloalkane compounds-IV. Synthesis of ′4-piperidine-5-spiro-2-oxazolidinones. Bull. Soc. Chim. Fr., 4, 1394-98 (1970).
7. Maillard, J., Langlois, M., Delaunary, P., Vo Van, T., Chenu, J., Morin, R., Benharkate, M., Manuel, C. and Motosso, F., Cycloalkane spiroheterocyclic compounds. J. Med Chem., 15, 1123-28 (1972).
8. Mauleon, D., Pujol, M. D. and Rosell, G., Synthesis and β-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols. J. Med. Chem., 31, 2122-26 (1988).
9. Mcleod, L. C. (1970). Pharmacological Experiments on Intact Preparations (E & S Livingstone, Edinburg) p. 63.
10. Saeed, M., Ahmad, M., Saify, Z. S., Zia, A., Ahmad, V. U. and Iqbal, Z., Synthesis and analgesic activity of 4-piperidinol derivatives. Pak. J. Pharm. Pb. Univ. Lahore, 9, 37-42 (1996).
11. Saeed, M., Saify, Iqbal, Z. and Islam, N. Synthesis of 4-hydroxipiperidine derivatives and their screening for analgesic activity. Arch. Pharm. Res., 20, 338-341 (1997).
12. Saify, Z. S., Saeed, M., Khan, A. Moazzam, H., Ahmad, V. U., Zia, A. and Haleem, D.J. Synthesis of some piperidine derivatives of potential analgesic activity. Proceed. 19th IUPAC Symp. on Chem. Nat. Products., Kar., Pak., 75-83 (1994a).
13. Saify, Z. S., Saeed, M., Moazzam, H., Yasmeen, A. Zafar, A. and Haleem, D. J., Studies on the effect of 4-hydroxy-4-phenylpiperidine derivative (4-HPPD) on mice brain dopamine metabolism. Proceed. ISBBP, Univ. Kar., Pak., 1, 36-39 (1994b).
14. Takai, H., Obase, H., Nakamizo, N., Teranishi, M., Kubo, K., Shuto, K. and Hashimoto, T., Synthesis and pharmacological evaluation of piperidine derivatives with various heterocyclic rings at the 4-position. Chem. Pharm. Bull., 33, 1104-1115 (1985a).
15. Takai, H., Obase, H., Teranishi, M., Karasawa, A., Kubo K., Shuto, K., Kasuya, Y., Hashikami, M., Karashima, N. and Shigenobu, K., Spiropiperidines-I. Synthesis of ′-substituted spiropiperidine derivatives and evaluation of their antihypertensive activity. Chem. Pharm. Bull., 33, 1129-39 (1985b).
16. Weiner, N. (1985). In: Goodman and Gilman's Pharmacological Basis of Therapeutics, Gilman, A. G., Goodman, L. S., Rall, T.W. and Murad, F. ed. (MacMillan, New York) p. 145.