Automated synthesis of 6-[18F]fluoro-L-DOPA using modified polystyrene supports with bound 6-mercuric DOPA precursors

Applied Radiation and Isotopes

Volumn 49, Issue 7, 1998, Pages 795-804

  Szajek, L P ^a   Channing, M A ^a   Eckelman, W C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLYSIS; MERCURY (METAL); POLYSTYRENES; SUBSTRATES; SYNTHESIS (CHEMICAL);

CHEMICAL YIELD;

RADIOACTIVE MATERIALS;

6 FLUORODOPA; DOPA; FLUORINE 18; MERCURY; POLYSTYRENE; RESIN;

ARTICLE; AUTOMATION; DRUG SYNTHESIS; HYDROLYSIS; POSITRON EMISSION TOMOGRAPHY; PRECURSOR; PRIORITY JOURNAL;

EID: 0032128449     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(97)00304-7     Document Type: Article

References (9)

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2. Darling, G. D. and Frechet, J. M. (1986) Chemical modification of polystyrene resins. Approaches to the binding of reactive functionalities to polystyrene resins through a dimethylene spacer. J. Org. Chem. 51, 2270-2276.
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8. 18F]fluoro-L-dopa for human studies with PET. Appl. Radial. Isot. 41, 275-281.
9. 18F]-FMEDOPA, a potentially-improved imaging agent for the presynaptic dopaminergic nervous system. Nucl. Med. Biol. 23, 857-865.