Low dihydrotestosterone and weight loss in the AIDS wasting syndrome

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 18, Issue 3, 1998, Pages 246-251

  Sattler, Fred ^a,b   Briggs, William ^a   Antonipillai, Indra ^a   Allen, Jon ^a   Horton, Richard ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b RAND CORPORATION   (United States)

Author keywords

5 Reductase; AIDS wasting; Dihydrotestosterone; Insulin like growth factor 1 (IGF 1); Testosterone; Weight loss

Indexed keywords

ANDROSTANOLONE; SOMATOMEDIN C; STEROID 5ALPHA REDUCTASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ANDROGEN THERAPY; ANTIBODY SPECIFICITY; ARTICLE; CLINICAL ARTICLE; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HYPOGAMMAGLOBULINEMIA; LYMPHOCYTE COUNT; MALE; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; SEXUAL FUNCTION; TESTOSTERONE BLOOD LEVEL; WASTING SYNDROME; WEIGHT REDUCTION;

EID: 0032127322     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199807010-00008     Document Type: Article

References (36)

1. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Report 1992;4:1-13.
2. Chan ISF, Neaton JD, Saravolatz LR, Crane LR, Osterberger J. Frequencies of opportunistic diseases prior to death among HIV-infected persons. AIDS 1995;9:1145-52.
3. Kotler DP, Tierney AR, Wang J, Pierson RN. Magnitude of body cell-mass depletion and time of death from wasting in AIDS. Am J Clin Nutr 1989;50:444-7.
4. Dobs AS, Dempsey MA, Ladenson PW, Polk BF. Endocrine disorders in men infected with human immunodeficiency virus. Am J Med 1988;84:611-16.
5. Croxson TS, William EC, Miller LK, Levit CD, Senie R, Zumoff B. Changes in the hypothalamic-pituitary-gonadal axis in human immunodeficiency virus infected homosexual men. J Clin Endocrinol Metab 1989;68:317-21.
6. Griggs RC, Kingston W, Jozefowicz RF, Hen BE, Forbes G, Halliday D. Effect of testosterone on muscle mass and muscle protein synthesis. Am J Appl Physiol 1989;66:498-503.
7. Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81:4358-65.
8. Wang C, Alexander G, Berman N, et al. Testosterone replacement therapy improves mood in hypogonadal men - a clinical research center study. J Clin Endocrinol Metab 1996;81:3578-83.
9. Brodsky IG, Balagopal P, Sreekumaran N. Effect of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men - a clinical research center study. J Clin Endocrinol Metab 1996;81:3469-75.
10. Bhasin S, Storer T, Berman N, et al. The effects of supraphysiologic doses of testosterone on muscle size and strength. N Engl J Med 1996;335:1-7.
11. Hengge UR, Baumann M, Maleba R, Brockmeyer NH, Goos M. Oxymethalone promotes weight gain in patients with advanced human immunodeficiency virus (HIV-1) infection. Br J Nutr 1996; 75:129-38.
12. Gold J, High HA, Yueming L, et al. Safety and efficacy of nandrolone decanoate for treatment of wasting in patients with HIV infection. AIDS 1996;10:745-57.
13. Berger JR, Pall L, Hall CD, Simpson DM, Berry PS, Dudley R. Oxandrolone in AIDS-wasting myopathy. AIDS 1996;10:1657-62.
14. Wilson J, Gloyna R. The intranuclear metabolism of testosterone. Recent Prog Horm Res 1971;26:309-30.
15. Snochowski M, Tonu S, Dahlberg E, Eriksson E, Gustafsson J-A. Androgen and glucocorticoid receptors in human skeletal muscle cytosol. J Steroid Biochem 1981;14:765-71.
16. Tonu S, Dahlberg E, Gustafsson J-A. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology 1984;114:2100-6.
17. Johnson MP, Murthy LR, Rowley DR, Young CYF, Scardino PT, Tindall DJ. Properties and isolation of androgen receptors from hyperplastic human prostate and other target tissues. In Rodgers CH, Coffey DS, Cunha G, Grashack JT, Hinman F, Horton R, eds. Benign prostatic hyperplasia, vol. 2., NIH publication No. 87-2881. Bethesda, MD: National Institutes of Health, 1987:189-98.
18. Mowszowicz I, Berthauit I, Mestayer C, Kuttenn F, Mauvais-Jarvis P. 5-alpha reductases: physiology and pathology. Ann Endocrinol (Paris) 1995;56:555-9.
19. Zhou ZX, Lane MV, Kemppainen JA, French FS, Wilson EM. Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Mol Endocrinol 1995;9:208-18.
20. Schaison G, Renoir M, Lagogney M, Mowszowicz I. On the role of dihydrotestosterone in regulating luteinizing hormone secretion in man. J Clin Endocrinol Metab 1980;51:1133-7.
21. Sparks R, Brewster SE, Libman H, Dezube BJ. Dihydrotestosterone gel: a novel androgen for AIDS wasting [abstract PI-319]. In Proceedings of the 79th meeting of the Endocrine Society, Minneapolis, MN, June 11-14, 1997:214.
22. Ishimaru T, Edmiston W, Pages L, Horton R. Splanchnic extraction and conversion of testosterone and dihydrotestosterone in man. J Clin Endocrinol 1978;46;528.
23. Horton R, Pasupuletti V, Antonipillai I. Androgen induction of steroid 5 α-reductase may be mediated via insulin-like growth factor-I. Endocrinology 1993;133:447-51.
24. Rabaud CH, Doussset B, Hussenet F, Amiel C, May TH, Canton PH. Disorders of somatotrophic axis in HIV-infected patients [abstract 126]. Third Conference on Retroviruses and Opportunistic Infections, Washington, D.C., U. S. A., February, 1996.
25. Sattler F, Dube M, Montgomery AB, LoPresti J, Leedom J, Nicoloff J. Phase I study of insulin like growth factor-1 (IGF-1) in HIV [abstract 112]. 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Florida, U. S. A., October, 1994 .
26. Grinspoon S, Corcoran C, Lee K, et al. Loss of lean body and muscle mass correlate with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. J Clin Endocrinol Metab 1996;81:4051-7.
27. Counts DR, Gwirtsman H, Carlsson LMS, Lesem M, Cutler GB. The effect of anorexia nervosa and refeeding on growth hormone-binding protein and insulin-like growth factors (IGFs) and the IGF-binding proteins. J Clin Endocrinol Metab 1992;75:762-7.
28. Jackson SW, Underwood LE, Clemmons DR. Effects of calorie or protein restriction on insulin-like growth factor-1 (IGF-1) and IGF binding proteins in children and adults. J Clin Endocrinol Metab 1995;80:443-9.
29. Cuttler L. Regulation of growth hormone secretion. Endocrinol Metab Clin North Am 1996;25:541-71.
30. Frost RA, Fuhrer J, Steigbigel R, Mariuz P, Lange CH, Gelato MC. Wasting in the acquired immune deficiency syndrome is associated with multiple defects in the serum insulin-like growth factor system. Clin Endocrinol 1996;44:501-14.
31. Liu L, Merriam GR, Sherins RJ. Chronic sex steroid exposure increases mean plasma growth hormone concentrations and pulse amplitude in men with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1989;64:651-6.
32. Weissberger AJ, Ho KFY. Activation of the somatotropic axis by testosterone in adult males; evidence for the role of aromatization. J Clin Endocrinol Metab 1993;76:1407-12.
33. Hobbs CJ, Plymate SR, Rosen CJ, Adler RA. Testosterone administration increases insulin-like growth factor-I levels in normal men. J Clin Endocrin Metab 1993;77:776-9.
34. Ashton WS, Degnan BM, Daniel A, Francis GL. Testosterone increases insulin-like growth factor-1 and insulin-like growth factor-binding protein. Ann Clin Lab Sci 1995;25:381-8.
35. Chuzel F, Clark AM, Avallet O, Saez JM. Transcriptional regulation of lutropin/human choriogonadotropin receptor and three enzymes of steroidogenesis by growth factors in cultured pig Leydig cells. Eur J Biochem 1996;239:8-16.
36. Martin ME, Benassayag C, Amiel C, Canton P, Nunex EA. Alterations in the concentrations and binding properties of sex steroid binding protein and corticosteroid-binding protein globulin in HIV+ patients. J Endocrinol Invest 1992;15:597-603.