Differential distribution, affinity and plasticity of dopamine D-1 and D-2 receptors in the target sites of the mesolimbic system in an animal model of ADHD

Behavioural Brain Research

Volumn 94, Issue 1, 1998, Pages 173-185

  Carey, Margaret P ^a   Diewald, Linda M ^a   Esposito, Felice J ^a   Pellicano, Mario P ^a   Gironi Carnevale, Ugo A ^a   Sergeant, Joseph A ^b   Papa, Michele ^c   Sadile, Adolfo G ^a  

^a Behaviour and Neural Networks D   (Italy)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

7 OH DPAT; Attention Deficit Hyperactivity Disorder; Autoradiography; Competition studies; Correlative analysis; DAT; Dopamine receptors; Dopamine transporter protein; Methylphenidate; Model; Quinpirole; Raclopride; Saturation analysis; SCH23390; Spontaneously hypertensive rat; VMAT 2

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE UPTAKE INHIBITOR; DRUG VEHICLE; METHYLPHENIDATE; QUINPIROLE; RACLOPRIDE; RECEPTOR SUBTYPE; SPIPERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; AUTORADIOGRAPHY; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG BINDING SITE; DRUG TARGETING; FOREBRAIN; INTRAPERITONEAL DRUG ADMINISTRATION; LIMBIC SYSTEM; MALE; MOLECULAR INTERACTION; NERVE CELL PLASTICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; NUCLEUS ACCUMBENS; OLFACTORY BULB; PRIORITY JOURNAL; PUTAMEN; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTORADIOGRAPHY; BRAIN MAPPING; DISEASE MODELS, ANIMAL; LIMBIC SYSTEM; MALE; MESENCEPHALON; NEURONAL PLASTICITY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTOR CROSS-TALK; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2;

EID: 0032126383     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)00178-2     Document Type: Article

References (70)

1. Amara S.G. Neurotransmitter transporters: recent progress. Annu Rev Neurosci. 16:1993;73-93.
2. Benkelfat C., Nordahl T.E., Semple W.E., King A.C., Murphy D.L., Cohen R.M. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Patients treated with clomipramine. Arch Gen Psychiatry. 47:1990;840-848.
3. 3H]spiroperidol binding in the corpus striatum and hypothalamus of spontaneously hypertensive rats. Eur J Pharmacol. 100:1984;109-112.
4. Bunzow J.R., Van Tol H.H.M., Grandy D.K., Albert P., Salon J., Christie J., Machida C.A., Neve K.A., Civelli O. Cloning and expression of a rat dopamine D2 receptor cDNA. Nature. 336:1988;783-787.
5. Carlson J.N., Visker K.E., Nielsen D.M., Keller Jr R.W., Glick S.D. Chronic antidepressant drug treatment reduces turning behavior and increases dopamine levels in the medial prefrontal cortex. Brain Res. 707:1996;122-126.
6. Cerbone A., Pellicano M.P., Sadile A.G. Evidence for and against the Naples Highand Low-Excitability rats as genetic model to study hippocampal functions. Neurosci Biobehav Rev. 17(3):1993;295-304.
7. 50) of an enzymatic reaction. Biochem Pharmacol. 22:1973;3099-3108.
8. 3H]spiroperidol binding in striatum of spontaneously hypertensive rat (SHR). Eur J Pharmacol. 82:1982;243-244.
9. Cook Jr E.H., Stein M.A., Krasowski M.D., Cox N.J., Olkon D.M., Kieffer J.E., Leventhal B.L. Association of attention-deficit disorder and the dopamine transporter gene. Am J: Hum Genet. 56:1995;993-998.
10. Dahlstrom A., Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in cell bodies of brain stem neurons. Acta Physiol Scand. 62 (S232):1964;1-55.
11. Dearry A., Gingrich J.A., Falardeau P., Fremeau R.T., Bates M.D., Caron M.G. Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature. 347:1990;72-76.
12. 3H]dopamine release from nucleus accumbens slices and monoamines levels in a rat model for attention-deficit hyperactivity disorder. Neurochem Res. 20:1995;427-433.
13. Edwards A.L. Statistical Methods for the Behavioral Sciences. 1967;Holt, Rinehart and Winston, New York.
14. Filipek P.A., Semrud-Clikeman M., Steingard R.J., Renshaw P.F., Kennedy D.N., Blederman J. Volumetric MRI analysis comparing Attention-Deficit Hyperactivity Disorder and normal controls. Neurology. 48:1997;589-601.
15. Gatley S.J., Pan D.F., Chen R.Y., Chaturvedi G., Ding Y.S. Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters. Life Sci. 58:1996;SL231-SL239.
16. Gerfen C.R., Keefe K.A., Gauda E.B. D1 and D2 dopamine receptor function in the striatum: Coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons. J Neurosci. 15:1995;8167-8176.
17. Geyer M.A. Serotonergic functions in arousal and motor activity. Behav Brain Res. 73:1996;31-35.
18. Giros B., Jaber M., Jones S.R., Wightman R.M., Caron M.G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 379:1996;606-612.
19. Grandy D.K., Zhang Y., Bouvier C., Zhou Q., Johnson R.A., Allen L., Buck K., Bunzow J.R., Salon J., Civelli O. Multiple D5 dopamine receptor genes: A functional receptor and two pseudogenes. Proc Natl Acad Sci USA. 88:1991;9175-9179.
20. Graybiel A.M., Aosaki T., Flaherty A.W., Kimura M. The basal ganglia and adaptive motor control. Science. 265:1994;1826-1831.
21. Halliwell J.V., Home A.L. Membrane properties of the granule cells of the islands of Calleja of the rat studied in vitro. J Physiol. 487:1995;421-440.
22. Hoebel B.G., Rada P., Mark G.P., Hernandez L. The power of integrative peptides to reinforce behavior by releasing dopamine. Ann N Y Acad Sci. 739:1994;36-41.
23. Hyttel J. SCH23 390-the first selective dopamine D-1 antagonist. Eur Pharmacol. 91:1983;153-154.
24. Kebabian J.W., Caine D.B. Multiple receptors for dopamine. Nature. 277:1979;9396.
25. Keynes R. HOX genes and regionalization of the nervous system. Annu Rev Neurosci. 17:1994;109-132.
26. Kilpatrick G.J., Hagan R.M., Gale J.D. 5-HT3 and 5-HT4 receptors in terminal regions of the mesolimbic system. Behav Brain Res. 7314:1996;11-13.
27. Kirouac G.J., Ganguly P.K. Up-regulation of dopamine receptors in the brain of the spontaneously hypertensive rat: an autoradiographic analysis. Neuroscience. 52:1993;135-141.
28. LaHoste G.J., Swanson J.M., Wigal S.B., Glabe C., Wigal T., King N., Kennedy J.L. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry. 1:1996;121-124.
29. Le Fur G., Guilloux F., Kabouche M., Mitrani N., Ferris O., Uzan A. Central dopaminergic neurons during development of genetic and DOCA-salt hypertension in the rat. DevBrain Res. 1:1981;153-163.
30. Lew M.J., Angus J.A. Analysis of competitive agonist-antagonist interactions by nonlinear regression. Trends Pharmacol Sci. 16:1995;328-337.
31. Lim D.K., Ito Y., Hoskins B., Rockhold R.W., Ho I.K. Comparative studies of muscarinic and dopamine receptors in three strains of rat. Eur J Pharmacol. 165:1989;279-287.
32. Lim D.K., Yu Z.J., Hoskins B., Rockhold R.W., Ho I.K. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: II. Dopamine receptors. Neurochem Res. 15:1990;621-627.
33. 3H]spiperone binding to rat brain regions. Proc Natl Acad Sci USA. 78:1981;2620-2624.
34. Liu L.X., Monsma F.J., Sibley D.R., Chiodo L.A. D2L, D2S, and D3 dopamine receptors stably transfected into NG108-15 cells couple to a voltage-dependent potassium current via distinct G protein mechanisms. Synapse. 24:1996;156-164.
35. Liu Y., Peter D., Merickel A., Krantz D., Finn J.P., Edwards R.H. A molecular analysis of vesicular monoamine transport. Behav Brain Res. 73:1996;51-58.
36. 3H]spiroperidol binding in the corpus striatum and hypothalamus of spontaneously hypertensive rats. Eur J Pharmacol. 100:1984;109-112.
37. Mark G.P., Weinberg J.B., Rada P.V., Hoebel B.G. Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus. Brain Res. 688:1995;184-188.
38. Marrocco R.T., Witte E.A., Davidson M.C. Arousal systems. Curr Opin Neurobiol. 4:1994;166-170.
39. Meiergerd S.M., Patterson T.A., Schenk J.O. D2 receptors may modulate the function of the striatal transporter for dopamine: evidence from studies in vitro and in vivo. Neurochemistry. 61:1993;764-767.
40. Meller E., Bohmaker K., Goldstein M., Basham D.A. Evidence that striatal synthesis-inhibiting autoreceptors are dopamine D3 receptors. Eur Pharmacol. 249:1993;R5-R6.
41. Nauta W.J.H., Smith J.P., Faull R.L.M., Domesick V.B. Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. Neuroscience. 3:1978;385-401.
42. Papa M., Sagvolden T., Sergeant J.A., Sadile A.G. Reduced CaMKII-positive neurones in the accumbal shell of an animal model of Attention-Deficit Hyperactivity Disorder. Neuroreport. 7:1996;3017-3020.
43. Papa M., Sagvolden T., Sergeant J.A., Sadile A.G. Quantitative cytochrome oxidase mapping study, cross-regional and neurobehavioral correlative analyses in the anterior forebrain of an animal model of ADHD. Behav Brain Res. 94:1998;197-211.
44. Papa M, Sagvolden T, Sergeant JA, Sadile AG. Reduced transduction mechanisms in the anterior accumbal interface of an animal model of ADHD. Behav Brain Res 1998, in press.
45. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, London.
46. Pilotte N.S., Sharpe L.G., Rountree S.D., Kuhar M.J. Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse. 22:1996;87-92.
47. Pontieri F.E., Tanda G., Di Chiara G. Intravenous cocaine, morphine and amphetamine preferentially increase extracellular dopamine in the 'shell' as compared with the 'core' of the rat nucleus accumbens. Proc Natl Acad Sci USA. 92:1995;12304-12308.
48. Posner M.I., Dehaene S. Attentional Networks. Trends Neurosci. 17:1994;75-79.
49. Rapoport J.L. The neurobiology of obsessive-compulsive disorder (clinical conference). J Am Med Assoc. 260:1988;2888-2890.
50. Reyneke L., Russell V.A., Taljaard J.J.F. Evidence that the stimulatory effect of neurotensin on dopamine release from rat nucleus accumbens slices is independent of dopamine D2-receptor activation. Brain Res. 534:1990;188-194.
51. Robbins T.W., Everett B.J. Arousal systems and attention. Gazzaniga M.S. The Cognitive Neurosciences. 1994;703-720 MIT Press, Cambridge, MA.
52. Robertson G.S., Jian M. D1 and D2 dopamine receptors differentially increase Fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrain. Neuroscience. 64:1995;1019-1034.
53. Rubenstein J.L., Martinez S., Shimamura K., Puelles L. The embryonic vertebrate forebrain: the prosomeric model. Science. 266:1994;578-580.
54. Russell V.A., de Villiers A.S., Sagvolden T., Lamm M.C.L., Taliaard J.J.F. Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of Attention-Deficit Hyperactivity Disorder-the spontaneously hypertensive rat. Brain Res. 676:1995;343-351.
55. 14C]-acetylcholine release in the dorsomedial part of the nucleus accumbens. Neurochem Res. 14:1998;877-881.
56. 3H]dopamine from brain slices suggest impaired vesicular storage of dopamine in an animal model of attention-deficit hyperactivity disorder. Behav Brain Res 1998, in press.
57. Safer D.J., Krager J.M. A survey of medication treatment for hyperactive/inattentive students. J Am Med Assoc. 260:1988;2256-2258.
58. Sagvolden T. The Attention Deficit Disorder might be a reinforcement deficit disorder. Georgas J., Manthouli M., Besevegis E., Kokkevi A. Contemporary Psychology in Europe: Theory, Research and Application. 1996;132-143 Hogrefe and Huber, Göttingen.
59. Seeman P., Van Tol H.H.M. Dopamine receptor pharmacology. Trends Pharmacol Sci. 15:1994;264-270.
60. Seiden L.S., Sabol K.E., Ricaurte G.A. Amphetamine: effects on catecholamine systems and behaviour. Annu Rev Pharmacol Toxicol. 32:1993;639-677.
61. Sergeant J.A., Steinhausen H.-C. European perspectives on hyperkinetic disorder. Eur Child Adolescent Psychiatry. 1:1992;34-41.
62. Shaywitz B.A., Yager R.D., Klopper J.H. An experimental model of minimal brain dysfunction (MBD) in developing rats. Science. 191:1976;305-307.
63. Sokoloff P., Giros B., Martres M.P., Bouthenet M.L., Schwartz J.C. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature. 347:1990;146-151.
64. Sunahara R.K., Guan H.C., O'Dowd B.F., Seeman P., Laurier L.G., Ng G., George S.R., Torchia J., Van Tol H.H.M., Niznik H.G. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 150:1991;614-619.
65. Surmeier J.D., Reiner A., Levine M.S., Ariano M.A. Are neostriatal dopamine receptors co-localized? Trends Neurosci. 16:1993;299-305.
66. Van Tol H.H.M., Bunzow J.R., Guan H.C., Sunahara R.H., Seeman P., Niznik H.B., Civelli O. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic dozapine. Nature. 350:1991;610-614.
67. Volkow N.D., Ding Y.-S., Fowler J.S., Wang G.-J., Logan J., Gatley J.S., Dewey S., Ashby C., Liebermann J., Hitzemann R., Wolf A.P. Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Arch Gen Psychiatry. 52:1995;456-463.
68. Watanabe M., Tsuruta S., Inoue Y., Kinnya M., Ogawa K., Mamiya G., Tatsunuma T. Dopamine D1 and D2 receptors in spontaneously hypertensive rat brain striatum. Can Physiol Pharmac. 67:1989;1596-1597.
69. Zahm D.S., Brog J.S. On the significance of subterritories in the 'Accumbens' part of the rat ventral striatum. Neuroscience. 50:1992;751-767.
70. Zilles K., Schleicher A., Rath M., Glaser T., Traber J. Quantitative autoradiography of transmitter binding sites with an image analyzer. J Neurosci Methods. 18:1986;207-220.