Effects of pedunculopontine tegmental nucleus lesions on responding for intravenous heroin under different schedules of reinforcement

Journal of Neuroscience

Volumn 18, Issue 13, 1998, Pages 5035-5044

  Olmstead, Mary C ^a   Munn, Elizabeth M ^b   Franklin, Keith B J ^c   Wise, Roy A ^b  

^a QUEEN S UNIVERSITY   (Canada)

^b and Applied Physiology   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Brainstem; Learning; Opiates; PPTg; Reward; Self administration

Indexed keywords

DIAMORPHINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ELECTROSTIMULATION; GIGANTOCELLULAR RETICULAR NUCLEUS; INSTRUMENTAL CONDITIONING; LEARNING; LIMBIC SYSTEM; MALE; MENTAL TASK; MOTOR SYSTEM; MUSCULOSKELETAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; REWARD; SIGNAL TRANSDUCTION; TASK PERFORMANCE;

EID: 0032125476     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-13-05035.1998     Document Type: Article

References (60)

1. Adams CD (1982) Variations in the sensitivity of instrumental responding to reinforcer devaluation. Q J Exp Psychol 34B:77-98.
2. Adams CD, Dickinson A (1981) Actions and habits: variations in associative representations during instrumental learning. In: Information processing in animals: memory mechanisms (Spear NE, Miller RR, eds). Hillsdale, NJ: Erlbaum.
3. Bechara A, van der Kooy D (1989) The tegmental pedunculopontine nucleus: a brain-stem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine. J Neurosci 9:3400-3409.
4. Bechara A, van der Kooy D (1992) A single brainstem substrate mediates the motivational effects of both opiates and food in non-deprived rats but not in deprived rats. Behav Neurosci 106:351-363.
5. Bechara A, Harrington F, Nader K, van der Kooy D (1992) Neurobiology of motivation: double dissociation of two motivational mechanisms mediating opiate reward in drug-naive versus drug-dependent animals. Behav Neurosci 106:798-807. \
6. Bertorelli R, Forloni G, Consolo S (1991) Modulation of the cortical in vivo ACh release by the basal nuclear complex; role of the pontomesencephalic tegmental area. Brain Res 563:353-356.
7. Bolles RC (1972) Reinforcement, expectancy, and learning. Psychol Rev 79:394-409.
8. Buscher W, Schugens M, Wagner U, Huston JP (1989) Interhemispheric relationship between lateral hypothalamic self-stimulation and the region of the nucleus tegmenti pedunculo-pontinus. Brain Res 487:321-334.
9. Dellu F, Mayo W, Cherkauoui J, LeMoal M, Simon H (1991) Learning disturbances following excitotoxin lesion of cholinergic pedunculopontine nucleus in the rat. Brain Res 544:126-132.
10. Dunbar JS, Hitchcock K, Latimer M, Rugg EL Ward N, Winn P (1992) Excitotoxin lesions of the pedunculopontine tegmental nucleus of the rat II. Examination of eating and drinking, rotation, and reaching and grasping following unilateral ibotenate or quinolinate lesions. Brain Res 589:194-206.
11. Fitzpatrick D, Diamond IT, Raczkowski D (1989) Cholinergic and monoaminergic innervation of the cat's thalamus: comparison of the lateral geniculate nucleus with other principal sensory nuclei. J Comp Neurol 288:647-675.
12. Fujimoto K, Yoshida M, Ikeguchi K, Niijima K (1989) Impairment of active avoidance produced after destruction of pedunculopontine nucleus areas in the rat. Neurosci Res 6:321-328.
13. Fujimoto K, Ikeguchi K, Yoshida M (1992) Impaired acquisition, preserved retention and retrieval of avoidance behavior after destruction of pedunculopontine nucleus areas in the rat. Neurosci Res 13:43-51.
14. Garcia-Rill E, Skinner RD, Gilmore SA, Owings R (1983) Connections of the mesencephalic locomotor region (MLR) II. Afferents and efferents. Brain Res Bull 10:63-71.
15. Glickman SE, Schiff BB (1967) A biological theory of reinforcement. Psychol Rev 74:81-109.
16. Guarraci F, Melanson N, Franklin KBJ, Olmstead MC (1994) Effects of PPTg lesions on the conditioned locomotor response to stimulants. Soc Neurosci Abstr 20:1029.
17. Hallanger AE, Levey AI, Lee HJ, Rye DB, Wainer BH (1987) The origins of cholinergic and other subcortical afferents to the thalamus in the rat. J Comp Neurol 262:105-124.
18. Hallanger AE, Wainer BH (1988) Ascending projections from the pedunculopontine tegmental nucleus and the adjacent mesopontine tegmentum in the rat. J Comp Neurol 274:483-515.
19. Herberg JL, Franklin KBJ (1972) Adrenergic feeding: its blockade or reversal by posterior VMH lesions; and a new hypothesis. Physiol Behav 8:1029-1034.
20. Inglis WL, Winn P (1995) The pedunculopontine tegmental nucleus: where the striatum meets the reticular formation. Prog Neurobiol 47:1-29.
21. Inglis WL, Dunbar JS, Winn P (1994) Outflow from the nucleus accumbens to the pedunculopontine tegmental nucleus: a dissociation between locomotor activity and the acquisition of responding for conditioned reinforcement stimulated by D-amphetamine. Neuroscience 62:51-64.
22. Keesey RE, Powley TL (1973) Self-stimulation and body weight in rats with lateral hypothalamic lesions. Am J Physiol 224:970-978.
23. Kessler J, Markowitsch HJ, Sigg G (1986) Memory related role of the posterior cholinergic system. J Neurosci 30:101-119.
24. Klitenick MA, Kalivas PW (1994) Behavioral and neurochemical studies of opioid effects in the pedunculopontine nucleus and mediodorsal thalamus. J Pharmacol Exp Ther 269:437-448.
25. Kofman O, Yeomans JS (1989) Cholinergic antagonists in ventral tegmentum elevate thresholds for lateral hypothalamic and brainstem self-stimulation. Pharmacol Biochem Behav 31:547-559.
26. Kofman O, McGlynn SM, Olmstead MC, Yeomans JS (1990) Differential effects of atropine, procaine and dopamine in the rat ventral tegmentum on lateral hypothalamic rewarding brain stimulation. Behav Brain Res 38:55-68.
27. Lepore M (1993) Parametric and neurological studies of brain stimulation reward. PhD thesis, McGill University.
28. Lepore M, Franklin KBJ (1996) N-Methyl-D-aspartate lesions of the pedunculopontine nucleus block acquisition and impair maintenance of responding reinforced with brain stimulation. Neuroscience 71:147-155.
29. Mogenson GJ (1987) Limbic-motor integration. Prog Psychobiol Physiol Psychol 12:117-170.
30. Mogenson GJ (1990) Brainstem systems for the control of behavioral acts. In: Brainstem mechanisms of behavior (Klemm WR, Vertes RP, eds), pp 171-195. New York: Wiley.
31. Mogenson GJ, Jones DL, Yim CY (1980) From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14:69-97.
32. Mogenson GJ, Yang CR (1991) The contribution of basal forebrain to limbic-motor integration and the mediation of motivation to action. Adv Exp Med Biol 295:267-290.
33. MunnEM, Olmstead MC, Franklin KBJ, Wise RA (1994) The effects of lesions of the pedunculopontine nucleus (PPN) on brain stimulation reward (BSR). Soc Neurosci Abstr 20:558.
34. Nader K, Bechara A, Roberts DCS, van der Kooy D (1994) Neuroleptics block high- but not low-dose heroin place preferences: Further evidence for a two-system model of motivation. Behav Neurosci 108:1128-1138.
35. Newman DB, Ginsberg CY (1994) Brain-stem reticular nuclei that project to the thalamus in rats: a retrograde tracer study. Brain Behav Evol 44:1-39.
36. Oakman SA, Paris PL, Cozzari C, Hartman BK (1995a) Evidence that pontomesencephalic cholinergic projections to midbrain dopaminergic groups are a subset of the tegmentothalamic projection. Soc Neurosci Abstr 21:68.
37. Oakman SA, Paris PL, Kerr PE, Cozzari C, Hartman BK (1995b) Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J Neurosci 15:5859-5869.
38. Olmstead MC, Franklin KBJ (1993) Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test. Neuroscience 57:411-418.
39. Olmstead MC, Franklin KBJ (1994a) Lesions of the pedunculopontine tegmental nucleus block drug-induced reinforcement but not amphetamine-induced locomotion. Brain Res 638:29-35.
40. Olmstead MC, Franklin KBJ (1994b) Lesions of the pedunculopontine tegmental nucleus abolish catalepsy and locomotor depression induced by morphine. Brain Res 662:134-140.
41. Olmstead MC, Eramian DR, Purdy DA, Franklin KBJ (1995) Effects of PPTg lesions on responding for sucrose reward on a progressive ratio schedule of reinforcement. Soc Neurosci Abstr 21:449.
42. Orlovsky GN (1970) Activity of reticulospinal neurons during locomotion. Biophys J 15:728-737.
43. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. New York: Academic.
44. Roberts DCS, Bennett SAL (1993) Heroin self-administration in rats under a progessive ratio schedule of reinforcement. Psychopharmacology 111:215-218.
45. Rugg EL, Dunbar JS, Latminer M, Winn P (1992) Comparison of the neurotoxic properties of various excitotoxins in the pedunculopontine tegmental nucleus of the rat, with particular reference to the loss of immunohistochemically identified cholinergic neurons. Brain Res 589:1-13.
46. Rye DB, Saper CB, Lee HJ, Wainer BH (1987) Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J Comp Neurol 259:483-528.
47. Sleeves JD, Jordan LM (1984) Autoradiographic demonstration of the projections from the mesencephalic locomotor region. Brain Res 307:263-276.
48. Steriade M, Datta S, Pare D, Oakson S, Curro R (1990) Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems. J Neurosci 10:2541-2559.
49. Sugimoto T, Hattori T (1984) Organization and efferent projections of nucleus tegmenti pedunculopontinus pars compacta with special reference to its cholinergic aspects. Neuroscience 11:931-946.
50. Swanson LW, Cowan WM (1975) A note on the connections and development of the nucleus accumbens. Brain Res 92:324-330.
51. Swanson LW, Mogenson GJ, Gerfen CR, Robinson P (1984) Evidencefor a projection from the lateral preoptic area and substantia innominata to the mesencephalic locomotor region in the rat. Brain Res 295:161-178.
52. Trojniar W, Staszewska M (1995) Bilateral lesions of the pedunculopontine tegmental nucleus affect feeding induced by electricalstimulation of the ventral tegmental area. Acta Neurobiol Exp 55:201-206.
53. Tsai CT, Mogenson GJ, Wu M, Yang CR (1989) A comparison o the effects of electrical stimulation of the amygdala and hippocampus on subpallidal output neurons to the pedunculopontine nucleus. Brain Res 494:22-29.
54. Vincent SR, Satoh K, Armstrong DM, Fibiger HC (1983) NADPH-diaphorase: a selective histochemical marker for the cholinergic neurons of the pontine reticular formation. Neurosci Lett 43:31-36.
55. Waraczynski M, Shizgal P (1995) self-stimulation of the MFB following parabrachial lesion. Physiol Behav 58:559-566.
56. Woolf NJ, Butcher LL (1986) Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain. Brain Res Bull 16:603-637.
57. Yeomans JS (1995) Role of tegmental cholinergic neurons in dopami- nergic activation, antimuscarinic psychosis and schizophrenia. Neuro- psychopharmacology 12:3-16.
58. Yeomans JS, Kofman O, McFarlane V (1985) Cholinergic involvemeni in lateral hypothalamic rewarding brain stimulation. Brain Res 329:19-26.
59. Yeomans JS, Mathur A, Tampakeras M (1993) Rewarding brain stimulation: role of tegmental cholinergic neurons that activate dopamine neurons. Behav Neurosci 107:1077-1087.
60. Yokel RA, Pickens R (1976) Extinction responding following amphetamine self-administration: determination of reinforcement magnitude Physiol Psychol 4:39-42.