Production of anti-polyubiquitin and anti-ubiquitin carboxyl terminal hydrolase antibodies and immunohistochemically assessment of them on brain sections of Alzheimer's disease and Lewy body disease

International Journal of Neuroscience

Volumn 95, Issue 1-2, 1998, Pages 33-42

  Pirim, Ibrahim ^a  

^a ATATURK UNIVERSITY   (Turkey)

Author keywords

Alzheimer's disease; Lewy body disease; Polyubiquitin; Ubiquitin carboxyl terminal hydrolase

Indexed keywords

EID: 0032125398     PISSN: 00207454     EISSN: None     Source Type: Journal    
DOI: 10.3109/00207459809000647     Document Type: Article

References (13)

1. Chau, V., Tobias, J & Bachmair, A. (1989) A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science, 243, 1576-1583.
2. Cole, G. & Timiras, P. (1987) Ubiquitin protein conjugates in Alzheimer lesions. Neuroscience letters, 79, 207-211.
3. Finley, D., Ozkaynak, E. & Varshavsky, A. (1987) The yeast polyubiquitin gene is essential for resistance to high temperature, starvation and other stress. Cell, 48, 1035-1046.
4. Finley, D , Bortel, B. & Varshavsky, A. (1989) The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis. Nature, 388, 394-401.
5. Haas, A. & Bright, P. (1985) The immunochemical detection and quantitation of intracellular ubiquitin protein conjugates. Journal of Biological Chemistry, 260(23), 12464-12470.
6. Harlow, E. & Lane, D. (1988) Antibodies (pp. 75-85, 300) USA: Cold Spring Harbor Laboratory.
7. Hershko, A. & Ciechanover, A. (1992) The ubiquitin system for protein degradation. Annual Review of Biochemistry, 61, 761-778.
8. Jentsch, S., Seufert, W. & Hauser, H. (1991) Genetic analysis of the ubiquitin system. Biochimica Et Biophysica Acta., 1089(2), 127-139.
9. Ozkaynak, E., Finley, D , Solomon, M. & Varshavsky, A. (1987) The yeast ubiquitin genes. EMBO Journal, 6, 1429-1439.
10. Pirim, I., Kiziltunc, A., Akcay, F. & Landon, M. (1995) Protein gene product (PGP9.5): purification from human brain, polyclonal antiserum production and staining of neurodegenerative diseased brain tissue. Turkish Journal of Medical Science, 24, 17-20.
11. Redman, K & Rechsteiner, M. (1989) Identification of the long ubiquitin extension as ribosomal protein S27. Nature, 338-444, 438-441.
12. Trausch, J. S., Grenfell, S. J. & H-Gearhart, P. M. (1993) Immunofluorescent localization of the ubiquitin activating enzyme (E1) to the nucleus and cytoskeleton. American Journal of Physiology, 264, C43-C102.
13. Vijay-Kumar, S., Burg, C. & Cook, W. (1985) Three dimensional structure of ubiquitin at 2.8A resolution. Proceedings of the National Academy of Sciences of the USA, 82, 3582-3587.