Change of antigenic and neutralizing specificity in substitutional epitope peptides of hemophilia B inhibitor

Peptides

Volumn 19, Issue 7, 1998, Pages 1129-1136

  Takahashi, Isao ^a   Yako, Fumie ^a   Saito, Hidehiko ^b,c   Kamiya, Tadashi ^a,b  

^a JAPANESE RED CROSS SOCIETY   (Japan)

^b Aichi Blood Dis Research Foundation   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigenicity; Factor IX; Hemophilia B inhibitor; Neutralization; Substitutional epitope peptide

Indexed keywords

BLOOD CLOTTING FACTOR 9; BOVINE SERUM ALBUMIN; EPITOPE; INHIBITOR PROTEIN; NEUTRALIZING ANTIBODY; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VALYLASPARAGINYLSERYLTHREONYLGLUTAMYLTYROSYLGLUTAMYLTHREONYLISOLEUCINE;

AMINO ACID SUBSTITUTION; ANTIGEN SPECIFICITY; ANTIGENICITY; ARTICLE; CASE REPORT; CONJUGATE; HEMOPHILIA B; HUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODIES; BINDING SITES; EPITOPES; FACTOR IX; HEMOPHILIA B; HUMANS; MALEIMIDES; NEUTRALIZATION TESTS; PEPTIDES; PROTEIN BINDING; SERUM ALBUMIN, BOVINE;

EID: 0032123577     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(98)00064-3     Document Type: Article

References (16)

1. Abildgaard C.F., Penner J.A., Watson-Williams E.J. Anti-inhibitor coagulant complex (Autoplex) for treatment of factor VIII inhibitors in hemophilia. Blood. 56:1980;978-984.
2. Brinkhous K.M., Hedner U., Garris J.B., Diness V., Read M.S. Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. Proc. Natl. Acad. Sci. USA. 86:1989;1382-1386.
3. Giannelli F., Choo K.H., Rees D.J.G., Boyd Y., Rizza C.R., Brown G.G. Gene deletions in patients with hemophilia B and anti-factor IX antibodies. Nature (London). 303:1983;181-182.
4. Hedner U., Glazer S., Pingel K., et al. Successful use of rFVIIa in a patient with severe hemophilia A subjected to synovectomy. Lancet. ii:1988;1193.
5. Hedner U. Factor VIIa in the treatment of hemophilia. Blood Coagul. Fibrin. 1:1990;307-317.
6. W.; Knatterud G. L. FEIBA Study Group. The use of factor eight inhibitor by-passing activity (FEIBA Immuno) product for treatment of bleeding episodes in hemophiliacs with inhibitors. Blood. 61:1983;36-40.
7. Hoyer L.W. Immunochemical properties of factor VIII and factor IX inhibitors. Blood Coagul. Fibrin. 2:1991;11-15.
8. Kamiya T., Takahashi I., Saito H. Retrospective study of inhibitor formation in Japanese hemophiliacs. Int. J. Hematol. 62:1995;175-181.
9. Lusher J.M., Blatt P.M., Penner J.A., et al. Autoplex versus Proplex: a controlled, double-blind study of effectiveness in acute hemarthroses in hemophiliacs with inhibitors to factor VIII. Blood. 62:1983;1135-1138.
10. Macik G.B., Hohneker J., Roberts H., Griffin A.M. The use of recombinant activated factor VII for treatment of a retropharyngeal hemorrhage in a hemophilic patient with a high titer inhibitor. Am. J. Hematol. 32:1989;232-234.
11. Matsushita T., Tanimoto M., Yamamoto K., et al. DNA sequence analysis of three inhibitor-positive hemophilia B patients without gross gene deletion: Identification of four novel mutation in factor IX gene. J. Lab. Clin. Med. 116:1990;492-497.
12. Mizuochi T., Taniguchi T., Fujikawa K., Titani K., Kobata A. The structure of the carbohydrate moieties of bovine blood coagulation factor IX (Christmas Factor). Occurrence of penta- and tetrasialyl triantennary sugar chains in the asparagine-linked sugar chains. J. Biol. Chem. 258:1983;6020-6024.
13. Takahashi I., Mizuno S., Takamatsu J., Kamiya T., Saito H. Epitope mapping of human factor IX inhibitor antibodies. Br. J. Haematol. 88:1994;166-173.
14. Tanimoto M., Kojima T., Kamiya T., et al. DNA analysis of seven patients with hemophilia B who have anti-factor IX antibodies: Relationship to clinical manifestations and evidence that the abnormal gene was inherited. J. Lab. Clin. Med. 112:1988;307-317.
15. Thompson A.R. Structure, function, and molecular defects of factor IX. Blood. 67:1986;565-572.
16. Yoshitake S., Schach B.G., Foster D.C., Davie E.W., Kurachi K. Nucleotide sequence of the gene for factor IX (antihemophilic factor B). Biochemistry. 25:1985;3736-3750.