Toward the identification of the cardiac cGMP inhibited-phosphodiesterase catalytic site

Journal of Computer-Aided Molecular Design

Volumn 12, Issue 4, 1998, Pages 361-

  Fossa, Paola ^a   Boggia, Raffaella ^a   Mosti, Luisa ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

3D SAR; Molecular modelling; Pharmacophoric model; Phosphodiesterase inhibitors

Indexed keywords

ENZYME INHIBITION; ESTERS; NUCLEOTIDES; PRINCIPAL COMPONENT ANALYSIS;

3D-SAR; CATALYTIC SITES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES; MECHANISM OF ACTION; PHARMACOPHORE MODELS; PHARMACOPHORIC MODEL; PHOSPHODIESTERASE INHIBITORS; PHOSPHODIESTERASES; PRIMARY MECHANISM; PROPERTY;

MOLECULAR MODELING;

3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CARDIOTONIC AGENT; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER AIDED DESIGN; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG DESIGN; ENZYMOLOGY; HEART MUSCLE; HUMAN; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; BINDING SITES; CARDIOTONIC AGENTS; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MYOCARDIUM; PHOSPHODIESTERASE INHIBITORS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0032110255     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1007928412086     Document Type: Article

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