Hepatoma with severe non-islet cell tumor hypoglycemia

American Journal of Gastroenterology

Volumn 93, Issue 6, 1998, Pages 997-1000

  Tietge, Uwe J F ^b   Schöfl, Christof ^b   Ocran, Kenneth W ^b   Wagner, Siegfried ^b   Böker, Klaus H W ^b   Brabant, Georg ^b   Zapf, Jürgen ^b   Manns, Michael P ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; INSULIN; NORADRENALIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 3;

ADULT; ARTICLE; CASE REPORT; DIET RESTRICTION; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOGLYCEMIA; LIVER CELL CARCINOMA; MALE; METASTASIS POTENTIAL; PANCREAS ISLET CELL CARCINOMA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TREATMENT FAILURE;

ADULT; CARCINOMA, HEPATOCELLULAR; HEPATITIS B, CHRONIC; HUMANS; HYPOGLYCEMIA; INSULIN-LIKE GROWTH FACTOR II; LIVER NEOPLASMS; MALE; PARANEOPLASTIC SYNDROMES;

EID: 0032105364     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.1998.00297.x     Document Type: Article

References (26)

1. 1. Service FJ. Hypoglycemic disorders. N Engl J Med 1995;332:1144-52.
2. 2. Zapf J. Insulinlike growth factor binding proteins and tumor hypoglycemia. Trends Endocrinol Metab 1995;6:37-42.
3. 3. Kahn CR. The riddle of tumour hypoglycemia revisited. J Clin Endocrinol Metab 1980;9:335-60.
4. 4. Daughaday WH, Emanuele MA, Brooks MH, et al. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med 1988;319:1434-40.
5. 5. Merimee TJ. Insulin-like growth factors in patients with non-islet cell tumours and hypoglycemia. Metabolism 1986;35:33-6.
6. 6. Widmer U, Zapf J, Froesch ER. Is extrapancreatic tumor hypoglycemia associated with elevated levels of insulin-like growth factor II? J Clin Endocrinol Metab 1982;55:833-839.
7. 7. Zapf J, Futo E, Peter M, et al. Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? J Clin Invest 1992;90:2574-84.
8. 8. Daughaday WH, Wu J-C, Lee S-D, et al. Abnormal processing of pro-IGF-II in patients with hepatoma and in some hepatitis B virus antibody-positive asymptomatic individuals. J Lab Clin Med 1990; 115:555-62.
9. 9. Baxter RC, Daughaday WH. Impaired formation of the ternary insulin-like growth factor binding protein complex in patients with hypoglycemia due to nonislet cell tumors. J Clin Endocrinol Metab 1991;73: 696-702.
10. 10. Petrides AS, DeFronzo RA. Glucose metabolism in cirrhosis: A review with some perspectives for the future. Diabetes Metab Rev 1989;5: 691-709.
11. 11. Bürgi H, Müller WA, Humbel RE, et al. Non-suppressible insulin-like activity of human serum. I. Physico-chemical properties, extraction and partial purification. Biochim Biophys Acta 1966;121:349-59.
12. 12. Froesch ER, Müller WA, Bürgi H, et al. Non-suppressible insulin-like activity of human serum. II. Biological properties of plasma extracts with non-suppressible insulin-like activity. Biochim Biophys Acta 1966;121:360-74.
13. 13. Rinderknecht E, Humbel RE. Aminoterminal sequences of two poly-peptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: Evidence for structural homology with insulin B chain. Proc Natl Acad Sci USA 1976;73:4379-4381.
14. 14. Rechler MM. Insulin-like growth factor binding proteins. Vitam Horm 1993;47:1-114.
15. 15. Baxter RC, Martin JL. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling. Proc Natl Acad Sci USA 1989;86:6898-6902.
16. 16. Binoux M, Hossenlopp P. Insulin-like growth factor (IGF) and IGF-binding proteins: Comparison of human serum and lymph. J Clin Endocrinol Metab 1988;67:509-14.
17. 17. Guler HP, Zapf J, Schmid C, et al. Insulin-like growth factors I and II in healthy man: Estimations of half-lives and production rates. Acta Endocrinol (Copenh) 1989;121:753-8.
18. 18. Daughaday WH, Kapadia M. Significance of abnormal binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors. Proc Natl Acad Sci USA 1989;73: 696-702.
19. 19. Donaghy A, Ross R, Gimson A, et al. Growth hormone, insulinlike growth factor-1, and insulinlike growth factor binding proteins 1 and 3 in chronic liver disease. Hepatology 1995;21:680-8.
20. 20. Kratzsch J, Blum WF, Schenker E, et al. Regulation of growth hormone (GH), insulin-like growth factor (IGF)I, IGF binding proteins-1, -2, -3 and GH binding protein during progression of liver cirrhosis. Exp Clin Endocrinol 1995;103:285-91.
21. 21. Zapf J. IGFs: Function and clinical importance: role of insulin-like growth factor (IGF) II and IGF binding proteins in extrapancreatic tumour hypoglycemia. J Intern Med 1993;234:543-52.
22. 22. Hunter SJ, Daughaday WH, Callender ME, et al. A case of hepatoma associated with hypoglycemia and overproduction of IGF-II (E-21): Beneficial effects of treatment with growth hormone and intrahepatic adriamycin. Clin Endocrinol 1994;41:397-401.
23. 23. Teale JD, Blum WF, Marks V. Allevation of non-islet cell tumor hypoglycemia by growth hormone therapy is associated with changes in IGF binding protein-3. Ann Clin Biochem 1992;29:314-22.
24. 24. Wing JR, Panz VR, Joffe WJ, et al. Hypoglycemia in hepatocellular carcinoma: Failure of short-term growth hormone administration to reduce enhanced glucose requirements. Metabolism 1991;40:508-12.
25. 111In-octreotide imaging and efficacy of octreotide, growth hormone and glucocorticosteroids. Clin Endocrinol 1996;44: 727-31.
26. 26. Samaan NA, Pham FK, Sellin RV, et al. Successful treatment of hypoglycemia using glucagon in a patient with an extrapancreatic tumor. Ann Intern Med 1990;113:404-6.