TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo

Journal of Physiology Paris

Volumn 92, Issue 3-4, 1998, Pages 205-208

  Debeir, Thomas ^a   Saragovi, H Uri ^a   Cuello, A Claudio ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE ACETYLTRANSFERASE; NERVE GROWTH FACTOR; PROTEIN TYROSINE KINASE INHIBITOR; SYNAPTOPHYSIN; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CHOLINERGIC NERVE CELL; CHOLINERGIC SYNAPSE; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SYNAPTOGENESIS;

EID: 0032105348     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(98)80011-9     Document Type: Conference Paper

References (17)

1. [1] Cuello A.C., Garofalo L., Kenigsberg R.L., Maysinger D., Gangliosides potentiate in vivo and in vitro effects of nerve growth factor on central cholinergic neurons, Proc. Natl. Acad. Sci. USA 86 (1989) 2056-2060.
2. [2] Cuello A.C., Thoenen H., The Pharmacology of Neurotrophic Factors, in: Claudio Cuello A., Collier B. (Eds.), Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s, Birkhauser Verlag, Basel, 1995, pp. 241-254.
3. [3] Debeir T., Benavides J., Vige X., Dual effects of thrombin and a 14-amino acid peptide agonist of the thrombin receptor on septal cholinergic neurons, Brain Res. 708 (1996) 159-166.
4. [4] Dreyfus C.F., Bernd, P., Martinez, H.J., Rubin, S.J. and Black, I.B., GABAergic and cholinergic neurons exhibit high affinity nerve growth factor binding in the rat basal forebrain, Exp.Neurol. 104 (1989) 181-185.
5. [5] Fonnum F., A rapid radiochemical method for the determination of choline acetyltransferase, J. Neurochem. 24 (1975) 407-409.
6. [6] Garofalo L., Ribeiro-da-Silva A., Cuello A.C., Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals, Proc. Natl. Acad. Sci. USA 89 (1992) 2639-2643.
7. [7] Garofalo L., Ribeiro-da-Silva A., Cuello A.C., Potentiation of nerve growth factor-induced alterations in cholinergic fibre length and presynaptic terminal size in cortex of lesioned rats by the monosialoganglioside GM1, Neuroscience 57 (1993) 21-40.
8. [8] Gnahn H., Hefti R, Heumann R., Schwab M.E., Thoenen H., NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?, Dev. Brain Res. 9 (1983) 45-52.
9. [9] Hatanaka H., Nihonmatsu I., Tsukui H., Nerve growth factor promotes survival of cultured magnocellular neurons from nucleus basalis of Meynert in postnatal rats, Neurosci. Lett. 90 (1988) 63-68.
10. [10] Johnston H.V., Rutkowski J.L., Wainer B.H., Long J.B., Mobley W.C., NGF effects on developing forebrain cholinergic neurons are regionally specific, Neurochem. Res. 12 (1987) 985-994.
11. [11] LeSauteur L., Wei L., Gibbs B.F., Saragovi H.U., Small peptide mimics of nerve growth factor bind TrkA receptors and affect biological responses J. Biol. Chem. 270 (1995) 6564-6569.
12. [12] LeSauteur L., Cheung N.K.V., Lisbona R., Saragovi H.U., Small molecule nerve growth factor analogs image receptors in vivo, Nature BioTech. 14 (1996) 1120-1122.
13. [13] Lewin G.R., Barde Y.A., Physiology of the neurotrophins, Annu. Rev. Neurosci. 19 (1996) 289-317.
14. [14] Lindsay R.M., Wiegand S.J., Altar C.A., DiStefano P.S., Neurotrophic factors: From molecule to man, Trends Neurosci. 17 (1994) 182-190.
15. [15] Paxinos G., Watson C., The rat brain in stereotaxic coordinates, Academic Press, Sydney, Australia, 1986.
16. [16] Thoenen H., The changing scene of neurotrophic factors, Trends Neurosci. 14 (1991) 165-170.
17. [17] Wong T.P., Campbell P.M., Ribeiro-da-silva A., Cuello A.C. Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing, Neuroscience 84 (1998) 403-412.