메뉴 건너뛰기




Volumn 90, Issue 5, 1998, Pages 199-206

The antithrombotic effect of potent bifunctional thrombin inhibitors based on hirudin sequence, P551 and P532, on He-Ne laser-induced thrombosis in rat mesenteric microvessels

Author keywords

Bifunctional thrombin inhibitor; He Ne laser; Hirudin; Platelet; Thrombin; Thrombosis

Indexed keywords

ARGATROBAN; DESULFATOHIRUDIN; HIRUDIN DERIVATIVE; HIRULOG; THROMBIN INHIBITOR;

EID: 0032104319     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(98)00023-1     Document Type: Article
Times cited : (8)

References (35)
  • 1
    • 0025676311 scopus 로고
    • Prevention of reocclusion by MCI-9038, a thrombin inhibitor, following t-PA-induced thrombolysis in a canine model of femoral arterial thrombosis
    • 1. Mellott MJ, Connolly TM, York SJ, Bush LR. Prevention of reocclusion by MCI-9038, a thrombin inhibitor, following t-PA-induced thrombolysis in a canine model of femoral arterial thrombosis. Thromb Haemost 1990;64: 526-53.
    • (1990) Thromb Haemost , vol.64 , pp. 526-553
    • Mellott, M.J.1    Connolly, T.M.2    York, S.J.3    Bush, L.R.4
  • 2
    • 0026335337 scopus 로고
    • The effect of thrombin inhibition in a rat arterial thrombosis model
    • 2. Broersma RJ, Kutcher LW, Heminger EF. The effect of thrombin inhibition in a rat arterial thrombosis model. Thromb Res. 1991;64:405-12.
    • (1991) Thromb Res , vol.64 , pp. 405-412
    • Broersma, R.J.1    Kutcher, L.W.2    Heminger, E.F.3
  • 3
    • 0027502204 scopus 로고
    • The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels
    • 3. Yamashita T, Yamamoto J, Sasaki Y, Matsuoka A. The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels. Thromb Res 1993;69:93-100.
    • (1993) Thromb Res , vol.69 , pp. 93-100
    • Yamashita, T.1    Yamamoto, J.2    Sasaki, Y.3    Matsuoka, A.4
  • 4
    • 0027184198 scopus 로고
    • Antithrombotic effect of argatroban on the pial vessels of the rat: A study with He-Ne laser-induced thrombosis formation
    • 4. Sasaki Y, Morili S, Yamashita T, Yamamoto J. Antithrombotic effect of argatroban on the pial vessels of the rat: A study with He-Ne laser-induced thrombosis formation. Haemostasis 1993;23:104-11.
    • (1993) Haemostasis , vol.23 , pp. 104-111
    • Sasaki, Y.1    Morili, S.2    Yamashita, T.3    Yamamoto, J.4
  • 5
    • 0028919701 scopus 로고
    • Thrombin hypothesis of thrombus generation and vascular lesion formation
    • 5. Harker LA, Hanson SR, Runge MS. Thrombin hypothesis of thrombus generation and vascular lesion formation. Am J Cardiol 1995;75: 12B-7B.
    • (1995) Am J Cardiol , vol.75
    • Harker, L.A.1    Hanson, S.R.2    Runge, M.S.3
  • 7
    • 0020404408 scopus 로고
    • Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation
    • 7. Esmon CT, Esmon NL, Harrir KW. Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem. 1982;257:7944-7.
    • (1982) J Biol Chem. , vol.257 , pp. 7944-7947
    • Esmon, C.T.1    Esmon, N.L.2    Harrir, K.W.3
  • 8
    • 0024393955 scopus 로고
    • 2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator
    • 2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc Natl Acad Sci USA 1989;86:7585-9.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7585-7589
    • Fitzgerald, D.J.1    Fitzgerald, G.A.2
  • 9
    • 0024345758 scopus 로고
    • Evaluation of the inhibition by heparin and hirudin of coagulation activation during r-tPA-induced thrombolysis
    • 9. Mirshahi M, Soria J, Soria C, Faivre R, Courtney M, Roitsch C, Tripier D, Caen JP. Evaluation of the inhibition by heparin and hirudin of coagulation activation during r-tPA-induced thrombolysis. Blood 1989;74:1025-30.
    • (1989) Blood , vol.74 , pp. 1025-1030
    • Mirshahi, M.1    Soria, J.2    Soria, C.3    Faivre, R.4    Courtney, M.5    Roitsch, C.6    Tripier, D.7    Caen, J.P.8
  • 11
    • 0024670167 scopus 로고
    • Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III. Implications for heparin efficacy
    • 11. Hogg PJ, Jackson CM. Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III. Implications for heparin efficacy. Proc Natl Acad Sci USA 1989;86:3619-23.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3619-3623
    • Hogg, P.J.1    Jackson, C.M.2
  • 12
    • 0025146426 scopus 로고
    • Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors
    • 12. Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J Clin Invest 1990;86:385-91.
    • (1990) J Clin Invest , vol.86 , pp. 385-391
    • Weitz, J.I.1    Hudoba, M.2    Massel, D.3    Maraganore, J.4    Hirsh, J.5
  • 15
    • 0026692059 scopus 로고
    • Comparative antithrombotic effects of heparin, recombinant hirudin and argatroban in a hamster femoral vein platelet-rich mural thrombosis model
    • 15. Imura Y, Stassen JM, Collen D. Comparative antithrombotic effects of heparin, recombinant hirudin and argatroban in a hamster femoral vein platelet-rich mural thrombosis model. J Pharmacol Exp Ther 1992;261:895-8.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 895-898
    • Imura, Y.1    Stassen, J.M.2    Collen, D.3
  • 17
    • 0022521744 scopus 로고
    • Kinetics of the inhibition of thrombin by hirudin
    • 17. Stone SR, Hofsteenge J. Kinetics of the inhibition of thrombin by hirudin. Biochemistry 1986;25: 4622-8.
    • (1986) Biochemistry , vol.25 , pp. 4622-4628
    • Stone, S.R.1    Hofsteenge, J.2
  • 18
    • 0028559927 scopus 로고
    • Design of potent bivalent thrombin inhibitors based on hirudin sequence: Incorporation of non-substrate-type active site inhibitors
    • 18. Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Fethiere J, Yue SY, Konishi Y. Design of potent bivalent thrombin inhibitors based on hirudin sequence: Incorporation of non-substrate-type active site inhibitors. Biochemistry 1994;33: 14443-51.
    • (1994) Biochemistry , vol.33 , pp. 14443-14451
    • Tsuda, Y.1    Cygler, M.2    Gibbs, B.F.3    Pedyczak, A.4    Fethiere, J.5    Yue, S.Y.6    Konishi, Y.7
  • 20
    • 0026731584 scopus 로고
    • Synthesis of a homologous series of ketomethylene arginyl pseudodipeptidea and application to low molecular weight hirudin-like thrombin inhibitors
    • 20. Dimaio J, Gibbs B, Lefebvre J, Konishi Y, Munn D, Yue SY, Hornberger W. Synthesis of a homologous series of ketomethylene arginyl pseudodipeptidea and application to low molecular weight hirudin-like thrombin inhibitors. J Med Chem 1992;35:3331-41.
    • (1992) J Med Chem , vol.35 , pp. 3331-3341
    • Dimaio, J.1    Gibbs, B.2    Lefebvre, J.3    Konishi, Y.4    Munn, D.5    Yue, S.Y.6    Hornberger, W.7
  • 21
    • 0024426079 scopus 로고
    • Effect of physical training on thrombotic tendency in rats: Decrease in thrombotic tendency measured by the He-Ne laser-induced thrombus formation method
    • 21. Yamamoto J, Iizumi H, Hirota R, Shimonaka K, Nagamatsu Y, Horie N, Morita S. Effect of physical training on thrombotic tendency in rats: Decrease in thrombotic tendency measured by the He-Ne laser-induced thrombus formation method. Haemostasis 1989;19:260-5.
    • (1989) Haemostasis , vol.19 , pp. 260-265
    • Yamamoto, J.1    Iizumi, H.2    Hirota, R.3    Shimonaka, K.4    Nagamatsu, Y.5    Horie, N.6    Morita, S.7
  • 22
    • 0016714950 scopus 로고
    • Evans Blue: An ideal energy-absorbing material to produce intravascular microinjury by He-Ne gas laser
    • 22. Kovacs IB, Tigy-Sebes A, Trombitas K, Gorog P. Evans Blue: An ideal energy-absorbing material to produce intravascular microinjury by He-Ne gas laser. Microvasc Res 1975;10: 107-24.
    • (1975) Microvasc Res , vol.10 , pp. 107-124
    • Kovacs, I.B.1    Tigy-Sebes, A.2    Trombitas, K.3    Gorog, P.4
  • 23
    • 0027140468 scopus 로고
    • Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris
    • 23. Sharma GVRK, Lapsley D, Vita JA, Sharma S, Coccio E, Adelman B, Loscalzo J. Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris. Am J Cardiol 1993;72:1357-60.
    • (1993) Am J Cardiol , vol.72 , pp. 1357-1360
    • Gvrk, S.1    Lapsley, D.2    Vita, J.A.3    Sharma, S.4    Coccio, E.5    Adelman, B.6    Loscalzo, J.7
  • 25
    • 0010515052 scopus 로고
    • An orally active, specific inhibitor of factor Xa prevents thrombosis without affecting bleeding time in rats
    • 25. Tanabe K, Hara T, Morishima Y, Ishihara H, Yokoyama A, Honda, Y, Iwamoto M. An orally active, specific inhibitor of factor Xa prevents thrombosis without affecting bleeding time in rats. Thromb Haemostas 1993;69: (Suppl)890.
    • (1993) Thromb Haemostas , vol.69 , Issue.SUPPL. , pp. 890
    • Tanabe, K.1    Hara, T.2    Morishima, Y.3    Ishihara, H.4    Yokoyama, A.5    Honda, Y.6    Iwamoto, M.7
  • 26
    • 0010481338 scopus 로고
    • Safe lasting interruption of arterial thrombosis by transient intravenous administration of tick anticoagulant peptide TAP
    • 26. Kelly AB, Hanson SR, Dunwiddie CT, Harker LA. Safe lasting interruption of arterial thrombosis by transient intravenous administration of tick anticoagulant peptide TAP (Abstract). Circulation 1992;86:(Suppl 1)I-411.
    • (1992) Circulation , vol.86 , Issue.SUPPL. 1
    • Kelly, A.B.1    Hanson, S.R.2    Dunwiddie, C.T.3    Harker, L.A.4
  • 27
    • 0028236252 scopus 로고
    • The antithrombotic effect of human activated protein C on He-Ne laser-induced thrombosis in rat mesenteric microvessels
    • 27. Yamashita T, Matsuoka A, Funatsu A, Yamamoto J. The antithrombotic effect of human activated protein C on He-Ne laser-induced thrombosis in rat mesenteric microvessels. Thromb Res 1994;75:33-40.
    • (1994) Thromb Res , vol.75 , pp. 33-40
    • Yamashita, T.1    Matsuoka, A.2    Funatsu, A.3    Yamamoto, J.4
  • 28
    • 0000828983 scopus 로고
    • Active site-inhibited factor VIIa blocks tissue factor activity and prevents arterial thrombus formation in baboons
    • 28. Lindahl AK, Wildgoose P, Lumsden AB, Allen R, Kelly AB, Harker LA, Hanson SR. Active site-inhibited factor VIIa blocks tissue factor activity and prevents arterial thrombus formation in baboons (Abstract). Circulation 1993; 88:(Suppl)I-417.
    • (1993) Circulation , vol.88 , Issue.SUPPL.
    • Lindahl, A.K.1    Wildgoose, P.2    Lumsden, A.B.3    Allen, R.4    Kelly, A.B.5    Harker, L.A.6    Hanson, S.R.7
  • 30
    • 0023184550 scopus 로고
    • Injury of brain microvessels with a helium-neon laser and Evans Blue can elicit local platelet aggregation without endothelial denudation
    • 30. Povlishok JT, Rosenblum WI. Injury of brain microvessels with a helium-neon laser and Evans Blue can elicit local platelet aggregation without endothelial denudation. Arch Pathol Lab Med 1987;111:415-21.
    • (1987) Arch Pathol Lab Med , vol.111 , pp. 415-421
    • Povlishok, J.T.1    Rosenblum, W.I.2
  • 31
    • 0019422496 scopus 로고
    • Coordinate binding of factor Va and factor Xa to the unstimulated platelet
    • 31. Tracy PB, Nesheim NE, Mam KG. Coordinate binding of factor Va and factor Xa to the unstimulated platelet. J Biol Chem 1981;256: 743-51.
    • (1981) J Biol Chem , vol.256 , pp. 743-751
    • Tracy, P.B.1    Nesheim, N.E.2    Mam, K.G.3
  • 32
    • 0018760408 scopus 로고
    • Binding of human thrombin to cultured human endothelial cells
    • 32. Awbrey BJ, Hoak JC, Owen WG. Binding of human thrombin to cultured human endothelial cells. J Biol Chem 1979;254:4092-5.
    • (1979) J Biol Chem , vol.254 , pp. 4092-4095
    • Awbrey, B.J.1    Hoak, J.C.2    Owen, W.G.3
  • 33
    • 0026441167 scopus 로고
    • Thrombin receptor 14-amino acid peptide binds to endothelial cell and stimulates calcium transients
    • 33. Tiruppathi C, Lum H, Andersen TT, Fenton JW, Malik AB. Thrombin receptor 14-amino acid peptide binds to endothelial cell and stimulates calcium transients. Am J Physiol 1992; 263:595-601.
    • (1992) Am J Physiol , vol.263 , pp. 595-601
    • Tiruppathi, C.1    Lum, H.2    Andersen, T.T.3    Fenton, J.W.4    Malik, A.B.5
  • 35
    • 0002633103 scopus 로고
    • Proteinase inhibitors: α-macroglobulins, serpins and kunins
    • Salzman RW, Editor. Philadelphia: J.B. Lippincott Co
    • 35. Salveson G, Pizzo SV. Proteinase inhibitors: α-macroglobulins, serpins and kunins. In: Salzman RW, Editor. Hemostasis and Thrombosis. Basic Principles and Clinical Practice. Philadelphia: J.B. Lippincott Co; p. 241-58. 1994.
    • (1994) Hemostasis and Thrombosis. Basic Principles and Clinical Practice , pp. 241-258
    • Salveson, G.1    Pizzo, S.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.