Flow cytometric analyses of the specific activation of peripheral blood mononuclear cells from healthy donors after in vitro stimulation with a fermented mistletoe extract and mistletoe lectins

European Journal of Cancer

Volumn 34, Issue 7, 1998, Pages 1105-1110

  Stein, G M ^a   Berg, P A ^b  

^a Herdecke Community Hospital   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Co stimulation; Flow cytometry; Mistletoe; PBMC; Specific immune system; Viscum album

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYCOPROTEIN GP 39; HLA DR ANTIGEN; PLANT EXTRACT; VISCUM ALBUM LECTIN;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; VISCUM ALBUM;

ADULT; ANTIGEN-ANTIBODY REACTIONS; B-LYMPHOCYTES; CELL COMMUNICATION; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; HUMANS; LECTINS; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MIDDLE AGED; MISTLETOE; MONOCYTES; PLANT EXTRACTS; PLANT LECTINS; PLANTS, MEDICINAL; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0032103912     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(98)00044-6     Document Type: Article

References (29)

1. Beuth J., Ko H.L., Gabius H.J., Burrichter H., Oette K., Pulverer G. Behaviour of lymphocyte subsets and expression of activation markers in response to immunotherapy with galacto side-specific lectin from mistletoe in breast cancer patients. Clin Invest. 70:1992;658-661.
2. Büssing A. Induction of apoptosis by mistletoe lectins. A review on the mechanisms of cytotoxicity mediated by Viscum album L. Apoptosis. 1:1996;25-32.
3. Fischer S., Scheffler A., Kabelitz D. Stimulation of the specific immune system by mistletoe extracts. Anti-Cancer Drugs. 8:(Suppl. 1):1997;S33-S37.
4. Franz H. Inhaltsstoffe der Mistel (Viscum album L.) als potentielle Arzneimittel. Die Pharmazie. 40:1985;97-104.
5. Jurin M., Zarkovic N. Antitumorous and immunomodulatory effects of the Viscum album L. preparation Isorel. Oncology. 50:1993;393-398.
6. Ribéreau-Gayon G., Jung M.L., Frantz M., Anton R. Modulation of the cytotoxicity and enhancement of cytokine release induced by misletoe (Viscum album L.) extracts or mistletoe lectins. Anti-Cancer Drugs. 8:(Suppl. 1):1997;S3-S8.
7. Schink M. Mistletoe therapy of human cancer - the role of the natural killer cell. Anti-Cancer Drugs. 8:(Suppl. 1):1997;S27-S51.
8. Stein G., Berg P.A. Non-lectin component in a fermented extract from Viscum album L. grown or pines induces proliferation of lymphocytes from healthy and allergic individuals in vitro. Eur J Clin Pharmacol. 47:1994;33-38.
9. Stein G.M., Meink H., Durst J., Berg P.A. The release of cytokines by a fermented lectin-1 (ML-1) free mistletoe extract reflects differences in the reactivity of PBMC in healthy and allergic individuals and tumour patients. Eur J Clin Pharmacol. 51:1996;247-252.
10. Hajto T., Hostanska K., Gabius H.J. Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res. 49:1989;4803-4808.
11. Hajto T., Hostanska K., Frei K., Rordorf C., Gabius H.J. Increased secretion of TNF-α, IL-1 and IL-6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res. 50:1990;3222-3226.
12. Salzer G. Pleura carcinosis, Cytomorphological findings with the mistletoe preparation Iscador and other pharmaceuticals. Oncology. 43:1986;66-70.
13. Stein G.M., Berg P.A. Evaluation of the stimulatory activity of a fermented mistletoe lectin-1 free mistletoe extract on T-helper cells and monocytes in healthy individuals in vitro. Arzneim-Forsch/Drug Res. 46:1996;635-639.
14. Janeway Jr C.A., Bottomly K. Signals and signs for lymphocyte responses. Cell. 76:1994;275-285.
15. June C.H., Bluestone J.A., Nadler L.M., Thompson C.B. The B7 and CD28 receptor families. Immunol Today. 15:1994;321-332.
16. Clark E.A., Ledbetter J.A. How B and T cells talk to each other. Nature. 367:1994;425-428.
17. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol. 12:1994;991-1045.
18. Reth M. The B-cell antigen receptor complex and co-receptors. Immunol Today. 16:1995;310-311.
19. + T-cell responses. Immunol Today. 17:1996;410-414.
20. Schultze J.L., Stettin A., Berg P.A. Demonstration of specifically sensitized lymphocytes in patients treated with an aqueous mistletoe extract (Viscum album L.). Klin Wochenschr. 69:1991;397-403.
21. Fischer S., Scheffler A., Kabelitz D. Oligoclonal in vitro response of CD4T cells to vesicles of mistletoe extracts in mistletoe-treated cancer patients. Cancer Immunol Immunother. 44:1997;150-156.
22. Mosman T.R., Coffman R.L. Heterogeneity of cytokine secretion patterns and function of helper T-cells. Adv Immunol. 46:1989;111-147.
23. Mosman T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today. 17:1996;138-146.
24. Berg P.A., Klein R., Röcken M. Cytokines in primary biliary cirrhosis. Semin Liver Dis. 17:1997;115-123.
25. Kuchroo VK, Prabhu Das M, Brown JA, et al. B7-1 and B7-1 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995, 80, 707-718.
26. Thompson C.B. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell. 81:1995;979-982.
27. Nickoloff B.J., Nestle F.O., Zheng X.G., Turka L.A. T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: a ligand for CD28. Blood. 83:1994;2180-2186.
28. Stein G.M., Stettin A., Schultze J., Berg P.A. Induction of anti-mistletoe lectin antibodies in relation to different mistletoe extracts. Anti-Cancer Drugs. 8:(Suppl. 1):1997;S57-S59.
29. Stettin A., Schultze J.L., Stechemesser E., Berg P.A. Anti-mistletoe-antibodies are produced in patients during therapy with an aqueous mistletoe extract derived from Viscum album L. and neutralize lectin-induced cytotoxicity in vitro. Klin Wochenschr. 68:1990;896-900.