The Xcad-2 gene can provide a ventral signal independent of BMP-4

Mechanisms of Development

Volumn 74, Issue 1-2, 1998, Pages 133-143

  Pillemer, Graciela ^a   Yelin, Ronit ^a   Epstein, Michal ^a   Gont, Linda ^b   Frumkin, Yaara ^a   Yisraeli, Joel K ^a   Steinbeisser, Herbert ^c   Fainsod, Abraham ^a  

^a HEBREW UNIVERSITY   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

Anterior posterior axis; Axis patterning; BMP 4; Caudal genes; Dorsoventral axis; Gastrulation; Homeobox; Spemann's organizer; Xcad 2; Xenopus embryo

Indexed keywords

BONE MORPHOGENETIC PROTEIN; AVIAN PROTEIN; BONE MORPHOGENETIC PROTEIN 4; CARRIER PROTEIN; DNA BINDING PROTEIN; GOOSECOID PROTEIN; HOMEODOMAIN PROTEIN; LIM 1 PROTEIN, XENOPUS; LIM-1 PROTEIN, XENOPUS; NERVE PROTEIN; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OTX; XENOPUS PROTEIN; XFKH1 PROTEIN, XENOPUS; XNOT 2 PROTEIN, XENOPUS; XNOT-2 PROTEIN, XENOPUS; XPO PROTEIN, XENOPUS; XVENT 1 PROTEIN, XENOPUS; XVENT 2 PROTEIN, XENOPUS; XVENT-1 PROTEIN, XENOPUS; XVENT-2 PROTEIN, XENOPUS;

ARTICLE; DEVELOPMENTAL GENETICS; EMBRYO; GASTRULA; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; HOMEOBOX; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; XENOPUS; ANIMAL; BIOSYNTHESIS; EMBRYONIC STRUCTURES; GENETICS; METABOLISM; MICROINJECTION; MORPHOGENESIS; PHYSIOLOGY; PRENATAL DEVELOPMENT; XENOPUS LAEVIS;

XENOPUS;

ANIMALS; AVIAN PROTEINS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CARRIER PROTEINS; DNA-BINDING PROTEINS; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GOOSECOID PROTEIN; HOMEODOMAIN PROTEINS; MICROINJECTIONS; NERVE TISSUE PROTEINS; ORGANIZERS, EMBRYONIC; OTX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 0032103831     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00075-6     Document Type: Article

References (63)

1. Amaya E., Stein P.A., Musci T.J., Kirschner M.W. FGF signaling in the early specification of mesoderm in Xenopus. Development. 118:1993;477-487.
2. Ault K.T., Dirksen M.-L., Jamrich M. A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos. Proc. Natl. Acad. Sci. USA. 93:1996;6415-6420.
3. Beck F., Erler T., Russell A., James R. Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev. Dyn. 204:1995;219-227.
4. Blitz I.L., Cho K.W.Y. Anterior neuroectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle. Development. 121:1995;993-1004.
5. Blumberg B., Wright C.V.E., De Robertis E.M., Cho K.W.Y. Organizer-specific homeobox genes in Xenopus laevis embryos. Science. 253:1991;194-196.
6. Chawengsaksophak K., James R., Hammond V.E., Köntgen F., Beck F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature. 386:1997;84-87.
7. Cho K.W.Y., Blumberg B., Steinbeisser H., De Robertis E.M. Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell. 67:1991;1111-1120.
8. Dale L., Howes G., Price B.M.J., Smith J.C. Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development. Development. 115:1992;573-585.
9. De Robertis E.M. Dismantling the organizer. Nature. 374:1995;407-408.
10. De Robertis E.M., Sasai Y. A common plan for dorsoventral patterning in Bilateria. Nature. 380:1996;37-40.
11. Dirksen M.L., Jamrich M. A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. Genes Dev. 6:1992;599-608.
12. Dosch R., Gawantka V., Delius H., Blumenstock C., Niehrs C. Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus. Development. 124:1997;2325-2334.
13. Epstein M., Pillemer G., Yelin R., Yisraeli J.K., Fainsod A. Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes. Development. 124:1997;3805-3814.
14. Fainsod A., Dießler K., Yelin R., Marom K., Epstein M., Pillemer G., Steinbeisser H., Blum M. The dorsalizing and neural inducing gene follistatin is an antagoinst of BMP-4. Mech. Dev. 63:1997;39-50.
15. Fainsod A., Steinbeisser H., De Robertis E.M. On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. EMBO J. 13:1994;5015-5025.
16. Feng J.Q., Chen D., Cooney A.J., Tsai M.-J., Harris M.A., Tsai S.Y., Feng M., Mundy G.R., Harris S.E. The mouse bone morphogenetic protein-4 gene. J. Biol. Chem. 270:1995;28364-28373.
17. Ferguson E.L. Conservation of dorsal-ventral patterning in arthropods and chordates. Curr. Opin. Genet. Dev. 6:1996;424-431.
18. Frumkin A., Haffner R., Shapira E., Tarcic N., Gruenbaum Y., Fainsod A. The chicken CdxA homeobox gene and axial positioning during gastrulation. Development. 118:1993;553-562.
19. Gamer L.W., Wright C.V.E. Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. Mech. Dev. 43:1993;71-81.
20. Gawantka V., Delius H., Hirschfeld K., Blemenstock C., Niehrs C. Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. EMBO J. 14:1995;6268-6279.
21. Gont L.K., Steinbeisser H., Blumberg B., De Robertis E.M. Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. Development. 119:1993;991-1004.
22. Graff J.M. Embryonic patterning: to BMP or not to BMP, that is the question. Cell. 89:1997;171-174.
23. Graff J.M., Thies R.S., Song J.J., Celeste A.J., Melton D.A. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell. 79:1994;169-179.
24. Harland R.M. The transforming growth factor β family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers. Proc. Natl. Acad. Sci. USA. 91:1994;10243-10246.
25. Hemmati-Brivanlou A., Melton D. Vertebrate embryonic cells will become nerve cells unless told otherwise. Cell. 88:1997;13-17.
26. Hogan B.L.M. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10:1996;1580-1594.
27. Joly J.S., Maury M., Joly C., Duprey P., Boulekbache H., Condamine H. Expression of a zebrafish caudal homeobox gene correlates with the establishment of posterior cell lineages at gastrulation. Differentiation. 50:1992;75-87.
28. Jones C.M., Dale L., Hogan B.L.M., Wright C.V.E., Smith J.C. Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. Development. 122:1996;1545-1554.
29. Jones C.M., Lyons K.M., Lapan P.M., Wright C.V.E., Hogan B.L.M. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development. 115:1992;639-647.
30. Kao R.K., Elinson R.P. The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos. Dev. Biol. 127:1988;64-77.
31. Köster M., Plessow S., Clement J.H., Lorenz A., Tiedemann H., Knöchel W. Bone morphogenetic protein 4 (BMP-4), a member of the TGF-β family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity. Mech. Dev. 33:1991;191-200.
32. Krieg P.A., Melton D.A. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNA. Nucl. Acids Res. 12:1984;7057-7070.
33. Kurihara T., Kitamura K., Takaoka K., Nakazato H. Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5′-untranslated region. Biochem. Biophys. Res. Commun. 192:1993;1049-1056.
34. Lamb T.M., Knecht A.K., Smith W.C., Stachel S.E., Economides A.N., Stahl N., Yancopolous G.D., Harland R.M. Neural induction by the secreted polypeptide noggin. Science. 262:1993;713-718.
35. Lemaire P., Kodjabachian L. The vertebrate organizer: structure and molecules. Trends Genet. 12:1996;525-531.
36. Maeno M., Ong R.C., Suzuki A., Ueno N., Kung H. A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm. Proc. Natl. Acad. Sci. USA. 91:1994;10260-10264.
37. Marom K., Shapira E., Fainsod A. The chicken caudal genes establish an anterior-posterior gradient by partially overlapping temporal and spatial patterns of expression. Mech. Dev. 64:1997;41-52.
38. Meyer B.I., Gruss P. Mouse Cdx-1 expression during gastrulation. Development. 117:1993;191-203.
39. Morales A.V., de la Rosa E., de Pablo F. Expression of the cCdx-B homeobox gene in chick embryo suggests its participation in rostrocaudal axial patterning. Dev. Dyn. 206:1996;343-353.
40. Nieuwkoop, P.D., Faber, J., 1975. Normal Table of Xenopus laevis (DAUDIN). North-Holland Publishing, Amsterdam.
41. Nishimatsu S., Suzuki A., Shoda A., Murakami K., Ueno N. Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos. Bichem. Biophys. Res. Commun. 186:1992;1487-1495.
42. Northrop J., Woods A., Seger R., Suzuki A., Ueno N., Krebs E., Kimelman D. BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus. Dev. Biol. 172:1995;242-252.
43. Northrop J.L., Kimelman D. Dorsal-ventral differences in Xcad-3 expression in response to FGF-mediated induction in Xenopus. Dev. Biol. 161:1994;490-503.
44. Onichtchouk D., Gawantka V., Dosch R., Delius H., Hirschfeld K., Blumenstock C., Niehrs C. The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm. Development. 122:1996;3045-3053.
45. Pannese M., Polo C., Andreazzoli M., Vignali R., Kablar B., Barsacchi G., Boncinelli E. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. Development. 121:1995;707-720.
46. Pillemer, G., Epstein, M., Blumberg, B., Yisraeli, J.K., De Robertis, E.M., Steinbeisser, H., Fainsod, A., 1998. Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis. Mech. Dev. 71, 193-196.
47. Pownall M.E., Tucker A.S., Slack J.M.W., Isaacs H.V. eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus. Development. 122:1996;3881-3892.
48. Re'em-Kalma Y., Lamb T., Frank D. Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development. Proc. Natl. Acad. Sci. USA. 92:1995;12141-12145.
49. Sasai Y., De Robertis E.M. Ectodermal patterning in vertebrate embryos. Dev. Biol. 182:1997;5-20.
50. Sasai Y., Lu B., Steinbeisser H., De Robertis E.M. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 376:1995;333-336.
51. Sato S.M., Sargent T.D. Localized and inducible expression of Xenopus-posterior (Xpo), a novel gene active in early frog embryos, encoding a protein with a 'CCHC' finger domain. Development. 112:1991;747-753.
52. Schmidt J.E., Suzuki A., Ueno N., Kimelman D. Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo. Dev. Biol. 169:1995;37-50.
53. Schmidt J.E., von Dassow G., Kimelman D. Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox. Development. 122:1996;1711-1721.
54. Slack J.M.W. Inducing factors in Xenopus early embryos. Curr. Biol. 4:1994;116-126.
55. Slack, J.M.W., Isaacs, H.V., Johnson, G.E., Lettice, L.A., Tannahill, D., Thompson, J., 1992. Specification of the body plan during Xenopus gastrulation: dorsoventral and anteroposterior patterning of the mesoderm. Development (Suppl.), 143-149.
56. Spemann H., Mangold H. Uber Induktion von Embryonalanlagen durch Implantation Artfremder Organisatoren. Roux's Arch. f. Entw. mech. 100:1924;599-638.
57. Steinbeisser H., Fainsod A., Niehrs C., Sasai Y., De Robertis E.M. The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss of function study using antisense RNA. EMBO J. 14:1995;5230-5243.
58. Subramanian V., Meyer B.I., Gruss P. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 83:1995;641-653.
59. Suzuki A., Thies R.S., Yamaji N., Song J.J., Wozney J.M., Murakami K., Ueno N. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proc. Natl. Acad. Sci. USA. 91:1994;10255-10259.
60. Taira M., Jamrich M., Good P.J., Dawid I.B. The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Genes Dev. 6:1992;356-366.
61. Wilson P.A., Hemmati-Brivanlou A. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature. 376:1995;331-333.
62. Winnier G., Blessing M., Labosky P.A., Hogan B.L.M. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9:1995;2105-2116.
63. Zoltewicz J.S., Gerhart J.C. The Spemann organizer of Xenopus is patterned along its anteroposterior axis at the earliest gastrula stage. Dev. Biol. 192:1997;482-491.