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1
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0030688004
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Variations on a theme: Cataloging human DNA sequence variation
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Collins F, Guyer M, Chakravarti A. Variations on a theme: cataloging human DNA sequence variation. Science. 278:1997;1580-1581.
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(1997)
Science
, vol.278
, pp. 1580-1581
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Collins, F.1
Guyer, M.2
Chakravarti, A.3
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2
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0030687515
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Whose DNA is it anyway?
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Marshall E. Whose DNA is it anyway? Science. 278:1997;564-567.
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(1997)
Science
, vol.278
, pp. 564-567
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Marshall, E.1
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3
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19244362853
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Linkage of frontotemporal dementia to chromosome 17: Clinical and neuropathological characterization of phenotype
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of special interest. The authors demonstrate linkage of a family with clinically and pathologically confirmed non-Alzheimer disease dementia to chromosome 17q21. Two other families with non-Alzheimer disease dementia have also been linked to this region. Although all three families exhibit diverse behavioral manifestations, neuropathological studies in each family are similar. Investigators thus believe that dementia in these families is linked to the same gene despite their varied clinical symptomatology.
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Yamaoka LH, Welsh-Bohmer KA, Hulette C, Gaskell P, Murray M, Rimmler J, Helms B, Guerra M, Roses A, Schmechel D, Pericak-Vance M. Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype. of special interest Am J Hum Genet. 59:1996;1306-1312 The authors demonstrate linkage of a family with clinically and pathologically confirmed non-Alzheimer disease dementia to chromosome 17q21. Two other families with non-Alzheimer disease dementia have also been linked to this region. Although all three families exhibit diverse behavioral manifestations, neuropathological studies in each family are similar. Investigators thus believe that dementia in these families is linked to the same gene despite their varied clinical symptomatology.
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(1996)
Am J Hum Genet
, vol.59
, pp. 1306-1312
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Yamaoka, L.H.1
Welsh-Bohmer, K.A.2
Hulette, C.3
Gaskell, P.4
Murray, M.5
Rimmler, J.6
Helms, B.7
Guerra, M.8
Roses, A.9
Schmechel, D.10
Pericak-Vance, M.11
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4
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0030977392
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Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference
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Foster N, Wilhelmsen K, Sima A, Jones M, D'Amato C, Gilman S. Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Ann Neurol. 41:1997;706-715.
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(1997)
Ann Neurol
, vol.41
, pp. 706-715
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Foster, N.1
Wilhelmsen, K.2
Sima, A.3
Jones, M.4
D'Amato, C.5
Gilman, S.6
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5
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0031045491
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Hereditary fronto-temporal dementia is linked to chromosome 17q21-q22: A genetic and clinicopathological study of three Dutch families
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Heutink P, Stevens M, Rizzu P, Bakker E, Kros J, Tibben A, Niermeijer M, van Duijn C, Oostra B, Swieten J. Hereditary fronto-temporal dementia is linked to chromosome 17q21-q22: a genetic and clinicopathological study of three Dutch families. Ann Neurol. 41:1997;150-159.
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(1997)
Ann Neurol
, vol.41
, pp. 150-159
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Heutink, P.1
Stevens, M.2
Rizzu, P.3
Bakker, E.4
Kros, J.5
Tibben, A.6
Niermeijer, M.7
Van Duijn, C.8
Oostra, B.9
Swieten, J.10
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6
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0031049348
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A critical review of genetic studies of schizophrenia. II. Molecular genetic studies
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Portin P, Alanen YO. A critical review of genetic studies of schizophrenia. II. Molecular genetic studies. Acta Psychiatrica Scandinavica. 95:1997;73-80.
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(1997)
Acta Psychiatrica Scandinavica
, vol.95
, pp. 73-80
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Portin, P.1
Alanen, Y.O.2
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7
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0031193992
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Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees
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of special interest. The authors conducted a genome scan of chromosome 6 in 53 families with sibpairs affected by schizophrenia, and found excess allele sharing identical by descent for several markers on 6q13-q26. A replication data set of 69 families also found excess allele sharing in this region, and an overlapping area of linkage by multipoint maximum likelihood analysis. A previously described linkage in 6p could not be confirmed.
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Cao Q, Martinez M, Zhang J, Sanders AR, Badner JA, Cravchik A, Markey CJ, Beshah E, Guroff JJ, Maxwell ME, et al. Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. of special interest Genomics. 43:1997;1-8 The authors conducted a genome scan of chromosome 6 in 53 families with sibpairs affected by schizophrenia, and found excess allele sharing identical by descent for several markers on 6q13-q26. A replication data set of 69 families also found excess allele sharing in this region, and an overlapping area of linkage by multipoint maximum likelihood analysis. A previously described linkage in 6p could not be confirmed.
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(1997)
Genomics
, vol.43
, pp. 1-8
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Cao, Q.1
Martinez, M.2
Zhang, J.3
Sanders, A.R.4
Badner, J.A.5
Cravchik, A.6
Markey, C.J.7
Beshah, E.8
Guroff, J.J.9
Maxwell, M.E.10
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9
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0031581749
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Can we find genes for schizophrenia?
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Kidd KK. Can we find genes for schizophrenia? Am J Med Genet. 74:1997;104-111.
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(1997)
Am J Med Genet
, vol.74
, pp. 104-111
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Kidd, K.K.1
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10
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0031459372
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Use of a quantitative trait to map a locus associated with severity of positive symptoms in familial schizophrenia to chromosome 6p
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of special interest. This paper highlights the potential utility of quantitative behavioral traits rather than categorical diagnoses in the detection of linkage in complex psychiatric disorders. The authors identified a potential susceptibility locus for schizophrenia on the short arm of chromosome 6 that they suggest is related to the severity of psychotic symptoms, rather than to the phenotype of schizophrenia per se.
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Brzustowicz LM, Honer WG, Chow EWC, Hogan J, Hodgkinson K, Bassett AS. Use of a quantitative trait to map a locus associated with severity of positive symptoms in familial schizophrenia to chromosome 6p. of special interest Am J Hum Genet. 61:1997;1388-1396 This paper highlights the potential utility of quantitative behavioral traits rather than categorical diagnoses in the detection of linkage in complex psychiatric disorders. The authors identified a potential susceptibility locus for schizophrenia on the short arm of chromosome 6 that they suggest is related to the severity of psychotic symptoms, rather than to the phenotype of schizophrenia per se.
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(1997)
Am J Hum Genet
, vol.61
, pp. 1388-1396
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Brzustowicz, L.M.1
Honer, W.G.2
Chow, E.W.C.3
Hogan, J.4
Hodgkinson, K.5
Bassett, A.S.6
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11
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12644303225
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Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
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of special interest
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Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA. 94:1997;587-592. of special interest.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 587-592
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Freedman, R.1
Coon, H.2
Myles-Worsley, M.3
Orr-Urtreger, A.4
Olincy, A.5
Davis, A.6
Polymeropoulos, M.7
Holik, J.8
Hopkins, J.9
Hoff, M.10
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12
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17344364792
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Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series
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McMahon FJ, Hopkins PJ, Xu J, McInnis MG, Shaw S, Cardon L, Simpson SG, MacKinnon DF, Stein OC, Sherrington R, et al. Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series. Am J Hum Genet. 61:1997;1397-1404.
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(1997)
Am J Hum Genet
, vol.61
, pp. 1397-1404
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McMahon, F.J.1
Hopkins, P.J.2
Xu, J.3
McInnis, M.G.4
Shaw, S.5
Cardon, L.6
Simpson, S.G.7
MacKinnon, D.F.8
Stein, O.C.9
Sherrington, R.10
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13
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0031471043
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Genetic segregation analysis of early-onset recurrent unipolar depression
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Marazita ML, Neiswanger K, Cooper M, Zubenko GS, Giles DE, Frank E, Kupfer DJ, Kaplan BB. Genetic segregation analysis of early-onset recurrent unipolar depression. Am J Hum Genet. 61:1997;1370-1378.
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(1997)
Am J Hum Genet
, vol.61
, pp. 1370-1378
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Marazita, M.L.1
Neiswanger, K.2
Cooper, M.3
Zubenko, G.S.4
Giles, D.E.5
Frank, E.6
Kupfer, D.J.7
Kaplan, B.B.8
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14
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0030976148
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Substantial genetic influence on cognitive abilities in twins 80 or more years old
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McClearn G, Johansson B, Berg S, Pedersen N, Ahern F, Petrill S, Plomin R. Substantial genetic influence on cognitive abilities in twins 80 or more years old. Science. 276:1997;1560-1563.
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(1997)
Science
, vol.276
, pp. 1560-1563
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McClearn, G.1
Johansson, B.2
Berg, S.3
Pedersen, N.4
Ahern, F.5
Petrill, S.6
Plomin, R.7
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15
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0030906941
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Twins: En route to QTLs for cognition
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Gottesman I. Twins: en route to QTLs for cognition. Science. 276:1997;1522-1523.
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(1997)
Science
, vol.276
, pp. 1522-1523
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Gottesman, I.1
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16
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0031940694
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Localisation of a gene implicated in a severe speech and language disorder
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of outstanding interest. The authors have localized a gene that appears to be crucial for the normal acquisition of language skills. A genome-wide screen for the locus responsible for a speech and language disorder segregating in an autosomal dominant fashion in a large three generation pedigree yielded strong evidence for linkage to markers in chromosome 7q31. Haplotype analysis indicates that the responsible gene lies within a 5.6 cM region on chromosome 7 which overlaps with a linkage finding for autism, another disorder involving delayed acquisition of language skills.
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Fisher S, Vargha-Khadem F, Watkins K, Monaco A, Pembrey M. Localisation of a gene implicated in a severe speech and language disorder. of outstanding interest Nat Genet. 18:1998;168-170 The authors have localized a gene that appears to be crucial for the normal acquisition of language skills. A genome-wide screen for the locus responsible for a speech and language disorder segregating in an autosomal dominant fashion in a large three generation pedigree yielded strong evidence for linkage to markers in chromosome 7q31. Haplotype analysis indicates that the responsible gene lies within a 5.6 cM region on chromosome 7 which overlaps with a linkage finding for autism, another disorder involving delayed acquisition of language skills.
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(1998)
Nat Genet
, vol.18
, pp. 168-170
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Fisher, S.1
Vargha-Khadem, F.2
Watkins, K.3
Monaco, A.4
Pembrey, M.5
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17
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6844251000
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A full genome screen for autism with evidence for linkage to a region on chromosome 7q
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The International Molecular Genetic Study of Autism Consortium. in press
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The International Molecular Genetic Study of Autism Consortium A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Hum Mol Genet. 1998;. in press.
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(1998)
Hum Mol Genet
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18
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20244377493
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Positional cloning of the mouse circadian Clock gene
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of outstanding interest. A phenotype-driven n-ethyl-n-nitrosourea mutagenesis screen was used to isolate a circadian rhythm mutant in the mouse. This mutation was then mapped and positionally cloned resulting in the identification of the mouse circadian Clock gene. Clock encodes a novel member of the highly conserved basic helix-loop-helix (bHLH) PERIOD-ARNT-SIM (PAS; three genes encoding transcription factors that have a basic helix-loop-helix motif at the DNA level) family of transcription factors. An A→T transversion at the third base position of the 5′ splice donor site of intron 19 of this gene proved to cause skipping of exon 19 resulting in the mutant phenotype.
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King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, et al. Positional cloning of the mouse circadian Clock gene. of outstanding interest Cell. 89:1997;641-653 A phenotype-driven n-ethyl-n-nitrosourea mutagenesis screen was used to isolate a circadian rhythm mutant in the mouse. This mutation was then mapped and positionally cloned resulting in the identification of the mouse circadian Clock gene. Clock encodes a novel member of the highly conserved basic helix-loop-helix (bHLH) PERIOD-ARNT-SIM (PAS; three genes encoding transcription factors that have a basic helix-loop-helix motif at the DNA level) family of transcription factors. An A→T transversion at the third base position of the 5′ splice donor site of intron 19 of this gene proved to cause skipping of exon 19 resulting in the mutant phenotype.
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(1997)
Cell
, vol.89
, pp. 641-653
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King, D.P.1
Zhao, Y.2
Sangoram, A.M.3
Wilsbacher, L.D.4
Tanaka, M.5
Antoch, M.P.6
Steeves, T.D.7
Vitaterna, M.H.8
Kornhauser, J.M.9
Lowrey, P.L.10
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19
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18844476167
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Functional identification of the mouse circadian Clock gene by transgenic BAC rescue
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of special interest. These authors helped to define the minimal genetic region containing the mouse Clock gene to 140kb by identifying a single BAC which restored the circadian rhythm mutant phenotype back to wild-type during transgenic BAC complementation analysis. These experiments provided both localization data and functional corroboration of the gene's identity. They propose that this method will greatly enhance the efficiency of future positional cloning projects in the mouse.
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Antoch MP, Song E, Chang A, Vitaterna MH, Zhao Y, Wilsbacher LD, Sangoram AM, King DP, Pinto LH, Takahashi J. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. of special interest Cell. 89:1997;655-667 These authors helped to define the minimal genetic region containing the mouse Clock gene to 140kb by identifying a single BAC which restored the circadian rhythm mutant phenotype back to wild-type during transgenic BAC complementation analysis. These experiments provided both localization data and functional corroboration of the gene's identity. They propose that this method will greatly enhance the efficiency of future positional cloning projects in the mouse.
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(1997)
Cell
, vol.89
, pp. 655-667
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Antoch, M.P.1
Song, E.2
Chang, A.3
Vitaterna, M.H.4
Zhao, Y.5
Wilsbacher, L.D.6
Sangoram, A.M.7
King, D.P.8
Pinto, L.H.9
Takahashi, J.10
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20
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0030885313
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RIGUI, a putative mammalian ortholog of the Drosophila period gene
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Sun S, Alsbrecht U, Zhuchenko O, Bailey J, Eichele G, Lee C. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell. 90:1997;1003-1011.
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(1997)
Cell
, vol.90
, pp. 1003-1011
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Sun, S.1
Alsbrecht, U.2
Zhuchenko, O.3
Bailey, J.4
Eichele, G.5
Lee, C.6
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21
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0030800739
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Circadian oscillation of a mammalian homologue of the Drosophila period gene
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Tei H, Okamura H, Shigeyoshi Y, Fukuhara C, Ozawa R, Hirose M, Sakaki Y. Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature. 389:1997;512-516.
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(1997)
Nature
, vol.389
, pp. 512-516
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Tei, H.1
Okamura, H.2
Shigeyoshi, Y.3
Fukuhara, C.4
Ozawa, R.5
Hirose, M.6
Sakaki, Y.7
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22
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0031459479
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Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript
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of outstanding interest. The mPer1 gene is a sequence homolog of Drosophila period that exhibits rhythmic expression in the SCN. Its expression is rapidly induced by short duration light exposure and correlates with the phase shifting of the overt rhythm. Expression of mPer1 in response to light appears to occur first in the ventrolateral neurons of the SCN which are also the neurons receiving information from the retina, indicating that the induction response to light is specifically localized in the SCN.
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Shigeyoshi Y, Taguchi K, Yamamoto S, Takekida S, Yan L, Tei H, Moriya T, Shibata S, Loros J, Dunlap J, Okamura H. Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. of outstanding interest Cell. 91:1997;1043-1053 The mPer1 gene is a sequence homolog of Drosophila period that exhibits rhythmic expression in the SCN. Its expression is rapidly induced by short duration light exposure and correlates with the phase shifting of the overt rhythm. Expression of mPer1 in response to light appears to occur first in the ventrolateral neurons of the SCN which are also the neurons receiving information from the retina, indicating that the induction response to light is specifically localized in the SCN.
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(1997)
Cell
, vol.91
, pp. 1043-1053
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Shigeyoshi, Y.1
Taguchi, K.2
Yamamoto, S.3
Takekida, S.4
Yan, L.5
Tei, H.6
Moriya, T.7
Shibata, S.8
Loros, J.9
Dunlap, J.10
Okamura, H.11
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23
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0345596433
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A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light
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of special interest. These investigators report the isolation of mammalian mper2, a gene which has similar properties to mper1 which was isolated previously and greater homology to Drosophila period. mper2 is expressed in a circadian pattern in the SCN but is not directly inducible by light like mper1 and has a different tissue expression profile. The authors postulate that these two proteins might act together to mediate diverse responses to an array of input cues from light to hormones or other signals.
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Albrecht U, Sun ZS, Eichele G, Lee CC. A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. of special interest Cell. 91:1997;1055-1064 These investigators report the isolation of mammalian mper2, a gene which has similar properties to mper1 which was isolated previously and greater homology to Drosophila period. mper2 is expressed in a circadian pattern in the SCN but is not directly inducible by light like mper1 and has a different tissue expression profile. The authors postulate that these two proteins might act together to mediate diverse responses to an array of input cues from light to hormones or other signals.
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(1997)
Cell
, vol.91
, pp. 1055-1064
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Albrecht, U.1
Sun, Z.S.2
Eichele, G.3
Lee, C.C.4
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24
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0031442734
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Natural variation in a Drosophila Clock gene and temperature compensation
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of special interest. Two major variants of a threonine-glycine (Thr-Gly) repeat within the clock period gene of Drosophila were found to be distributed over a distinct latitudinal cline in Europe. The (Thr-Gly) 17 repeat was seen almost exclusively in the mediterranean regions and the (Thr-Gly)20 repeat predominated in northern Europe. Subsequent experiments showed that the (Thr-Gly)17 variant has a period close to 24 hours at warmer temperatures but its period shortens significantly in colder temperatures. The (Thr-Gly)20 variants keep their period length close to 24 hours over a wider variation of temperature and are thus better suited to the temperature fluctuations of northern climates.
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Sawyer LA, Hennessy JM, Peixoto AA, Rosato E, Parkinson H, Costa R, Kyriacou CP. Natural variation in a Drosophila Clock gene and temperature compensation. of special interest Science. 278:1997;2117-2120 Two major variants of a threonine-glycine (Thr-Gly) repeat within the clock period gene of Drosophila were found to be distributed over a distinct latitudinal cline in Europe. The (Thr-Gly) 17 repeat was seen almost exclusively in the mediterranean regions and the (Thr-Gly)20 repeat predominated in northern Europe. Subsequent experiments showed that the (Thr-Gly)17 variant has a period close to 24 hours at warmer temperatures but its period shortens significantly in colder temperatures. The (Thr-Gly)20 variants keep their period length close to 24 hours over a wider variation of temperature and are thus better suited to the temperature fluctuations of northern climates.
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(1997)
Science
, vol.278
, pp. 2117-2120
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Sawyer, L.A.1
Hennessy, J.M.2
Peixoto, A.A.3
Rosato, E.4
Parkinson, H.5
Costa, R.6
Kyriacou, C.P.7
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25
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0030771199
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Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila
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of special interest. The authors observed two behavioral variations of the fly food search phenotype ('for') called 'rover' (forR) and 'sitter' (forS). They identified dg2 encoding a cGMP-dependent protein kinase (PKG) as the responsible gene.
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Osborne DA, Robichon A, Burgess E, Butland S, Shaw RA, Coulthard A, Pereira HS, Greenspan RJ, Sokolowski MB. Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. of special interest Science. 277:1997;834-836 The authors observed two behavioral variations of the fly food search phenotype ('for') called 'rover' (forR) and 'sitter' (forS). They identified dg2 encoding a cGMP-dependent protein kinase (PKG) as the responsible gene.
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(1997)
Science
, vol.277
, pp. 834-836
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Osborne, D.A.1
Robichon, A.2
Burgess, E.3
Butland, S.4
Shaw, R.A.5
Coulthard, A.6
Pereira, H.S.7
Greenspan, R.J.8
Sokolowski, M.B.9
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26
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0030848970
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A multigene family encoding a diverse array of putative pheromone receptors in mammals
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of special interest. The vomeronasal organ of mammals contains two subsets of sensory neurons. Sensory neurons that detect pheromones express different G proteins. The authors used single cell PCR to identify a novel multigene family of pheromone receptors (VRs) expressed in one particular subset of these sensory neurons. At least one cluster of genes encoding these VRs is linked to an olfactory receptor gene locus implying an evolutionary connection between these systems. Multiple variant mRNAs for VRs were also observed which may be part of a system for detection of diverse stimuli.
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Matsunami H, Buck LB. A multigene family encoding a diverse array of putative pheromone receptors in mammals. of special interest Cell. 90:1997;775-784 The vomeronasal organ of mammals contains two subsets of sensory neurons. Sensory neurons that detect pheromones express different G proteins. The authors used single cell PCR to identify a novel multigene family of pheromone receptors (VRs) expressed in one particular subset of these sensory neurons. At least one cluster of genes encoding these VRs is linked to an olfactory receptor gene locus implying an evolutionary connection between these systems. Multiple variant mRNAs for VRs were also observed which may be part of a system for detection of diverse stimuli.
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(1997)
Cell
, vol.90
, pp. 775-784
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Matsunami, H.1
Buck, L.B.2
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27
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0030788436
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A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution
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of special interest. These authors also used a single cell PCR approach (see [26]) to independently detect the novel gene family of VR receptors described above. They also observed that the two subsets of pheromone receptors were organized into discrete and sexually dimorphic regions in the vomeronasal organ and that these distributions also changed with age. They postulated that such an arrangement could lead to differential responses to hormones on the basis of gender and sexual maturity.
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Herrada G, Dulac C. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. of special interest Cell. 90:1997;763-773 These authors also used a single cell PCR approach (see [26]) to independently detect the novel gene family of VR receptors described above. They also observed that the two subsets of pheromone receptors were organized into discrete and sexually dimorphic regions in the vomeronasal organ and that these distributions also changed with age. They postulated that such an arrangement could lead to differential responses to hormones on the basis of gender and sexual maturity.
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(1997)
Cell
, vol.90
, pp. 763-773
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Herrada, G.1
Dulac, C.2
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28
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0030803414
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Olfactory receptors, vomeronasal receptors, and the organization olfactory information
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Bargmann CI. Olfactory receptors, vomeronasal receptors, and the organization olfactory information. Cell. 90:1997;585-587.
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(1997)
Cell
, vol.90
, pp. 585-587
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Bargmann, C.I.1
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0030743304
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Brain dopamine receptor plasticity: Testing a diathesis-stress hypothesis in an animal model
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Cabib S, Oliverio A, Ventura R, Lucchese F, Puglisi-Allegra S. Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model. Psychopharmacology. 132:1997;153-160.
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(1997)
Psychopharmacology
, vol.132
, pp. 153-160
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Cabib, S.1
Oliverio, A.2
Ventura, R.3
Lucchese, F.4
Puglisi-Allegra, S.5
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30
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0030667886
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Quantitative trait locus analysis of contextual fear conditioning in mice
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of special interest. Contextual fear conditioning is mediated by at least two neural circuits, the fear response governed by the amygdala and the contextual response governed by the hippocampus. In order to identify QTLs for various aspects of contextual fear, the authors measured intercrossed mice for freezing in response to static context, altered context and auditory cues. They identified three promising QTLs for these various measures.
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Wehner J, Radcliffe R, Rosmann S, Christensen S, Rasmussen D, Fulker D, Wiles M. Quantitative trait locus analysis of contextual fear conditioning in mice. of special interest Nat Genet. 17:1997;331-334 Contextual fear conditioning is mediated by at least two neural circuits, the fear response governed by the amygdala and the contextual response governed by the hippocampus. In order to identify QTLs for various aspects of contextual fear, the authors measured intercrossed mice for freezing in response to static context, altered context and auditory cues. They identified three promising QTLs for these various measures.
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(1997)
Nat Genet
, vol.17
, pp. 331-334
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Wehner, J.1
Radcliffe, R.2
Rosmann, S.3
Christensen, S.4
Rasmussen, D.5
Fulker, D.6
Wiles, M.7
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31
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0030725028
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Freezel
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Flint J. Freezel. Nat Genet. 17:1997;250-251.
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(1997)
Nat Genet
, vol.17
, pp. 250-251
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Flint, J.1
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0030722279
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Quantitative trait loci analysis affecting contextual conditioning in mice
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