Topical local anaesthetics (EMLA®) inhibit burn-induced plasma extravasation as measured by digital image colour analysis

Burns

Volumn 24, Issue 4, 1998, Pages 313-318

  Jönsson, Anders ^a   Mattsson, Ulf ^b   Tarnow, Peter ^b   Nellgård, Per ^a   Cassuto, Jean ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Anesthetics; Burns; Computer assisted image analysis; Lidocaine; Local; Oedema; Prilocaine; Rat

Indexed keywords

ALBUMIN; EMLA; EVANS BLUE; LIDOCAINE; LOCAL ANESTHETIC AGENT; PRILOCAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; BURN; CONTROLLED STUDY; EXTRAVASATION; IMAGE ANALYSIS; MALE; NONHUMAN; PHOTOGRAPHY; RAT; SKIN BLOOD FLOW; SKIN COLOR; SKIN EDEMA; TIME; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANESTHETICS, LOCAL; ANIMALS; BURNS; CAPILLARY PERMEABILITY; COLORING AGENTS; EDEMA; EVANS BLUE; EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; FOLLOW-UP STUDIES; IMAGE PROCESSING, COMPUTER-ASSISTED; LIDOCAINE; MALE; OINTMENTS; PHOTOGRAPHY; PRILOCAINE; RATS; RATS, SPRAGUE-DAWLEY; SKIN;

EID: 0032103611     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-4179(98)00011-4     Document Type: Article

References (41)

1. [1] Haegerstrand A, Dalsgaard C-J, Jonsson C-E. Effects of capsaicin pretreatment on the inflammatory response to scalding injury in the rat. Acta Physiologica Scandinavia 1987; 130: 345-348.
2. [2] Saria A. Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury. British Journal of Pharmacology 1984;82:217-222.
3. [3] Cassuto J, Nellgård P, Stage L, Jonsson A. Amide local anesthetics reduce albumin extravasation in burn injuries. Anesthesiology 1990;72:302-307.
4. [4] Lund T, Reed RK. Alpha-trinositol inhibits edema generation and albumin extravasation in thermally injured skin. Journal of Trauma 1994;36:761-765.
5. [5] Leape LL. Kinetics of burn edema formation in primates. Annals of Surgery 1972;176:223-226.
6. [6] Salmon GK, West GB. Variation in the response of rats to chemical and thermal injury. British Journal of Pharmacology 1973;47:625P-626P.
7. [7] Smahel J. Reduction of thermal oedema with Venalot. Burns 1978;4:157-159.
8. [8] Friedl HP, Till GO, Trentz O, Ward PA. Roles of histamine, complement and xanthine oxidase in thermal injury of skin. American Journal of Pathology 1989; 135: 203-217.
9. [9] Boykin JV Jr, Eriksson E, Sholley MM, Pittman RN. Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment. Science 1980;209:815-817.
10. [10] Holliman CJ, Meuleman TR, Larsen KR et al. The effect of ketanserin, a specific serotonin antagonist, on burn shock hemodynamic parameters in a porcine burn model. Journal of Trauma 1983;23:867-871.
11. [11] Carvajal HF, Brouhard BH, Linares HA. Effect of antihistamine-antiserotonin and ganglionic blocking agents upon increased capillary permeability following burn trauma. Journal of Trauma 1975;15:969-975.
12. [12] Alexander F, Mathieson M, Teoh KH et al. Arachidonic acid metabolites mediate early burn edema. Journal of Trauma 1984;24:709-712.
13. [13] Denzlinger C, Rapp S, Hagmann W, Keppler D. Leukotrienes as mediators in tissue trauma. Science 1985;230:330-332.
14. 4 excretion in patients with ARDS and severe burns. Prostaglandins Leukotrienes and Essential Fatty Acids 1991;43:151-158.
15. [15] Arturson G, Junsson C-E. Effects of 0-(β-hydroxyethyl)-rutosides (HR) and indomethacin on transcapillary macro-molecular transport: and protaglandins following scalding injury. Bibliog of Anatomy 1973;12:456-470.
16. [16] Heggers JP, Loy GL, Robson MC, Robson JDE. Histological demonstrations of prostaglandins and thromboxanes in burned tissues. Journal of Surgery Research 1980;28:110-117.
17. [17] Ehrlich HP, Needle AL, Rajaratnam J, White ME, White BS. The role of prostacyclin and thromboxane in rat burn and freeze injuries. Experimental Molecular Pathology 1983;38:357-367.
18. [18] Rimbäck G, Cassuto J, Wallin G, Westlander G. Inhibition of peritonitis by amide local anesthetics. Anesthesiology 1988;69:881-886.
19. [19] Nellgård P, Jönsson A, Bojö L, Tarnow P, Cassuto J. Small-bowel obstruction and effects of lidocaine, atropine and hexamethonium on inflammation and fluid losses. Acta Anaesthesiologia Scandinavia 1996;40:287-292.
20. [20] Horrobin DF, Mankau MS. Roles of prostaglandins suggested by the prostaglandin agonist/antiagonist actions og local anesthetic, anti-arrhythmic, anti-malarial, tricyclic anti-depressant and methyl xanthine compounds, effects on membranes and on nucleic acid function. Medical Hypotheses 1977;3:71-86.
21. [21] Goel RK, Tavares IA, Nellgård P, Jönsson A, Cassuto J, Bennett A. Effect of lignocaine on eicosanoid synthesis by pieces of human gastric mucosa. Journal of Pharmacy and Pharmacology 1994;46:319-320.
22. [22] Kunze H, Bohn E, Vogt W. Effects of local anaesthetics on prostaglandin biosynthesis in vitro. Biochimica et Biophysica Acta 1974;360:260-269.
23. 4 release and IL-1 secretion in vitro. Acta Anaesthesiologia Scandinavia 1993;37:159-165.
24. [24] Kazimierczak W, Peret M, Maslinski C. The action of local anaesthetics on histamine release. Biochemistry and Pharmacology 1976;25:1747-1750.
25. [25] Jönsson A, Mattsson U, Cassuto J and Heyden G. Quantification of burn induced extravasation of Evans blue albumin based on digital image color analysis. Computers in Biology and Medicine 1998 (in press)
26. [26] Johns RA, DiFazio CA, Longnecker DE. Lidocaine constricts or dilates rat arterioles in a dose-dependent manner. Anesthesiology 1985;62:141-144.
27. [27] Guinard JP, Carpenter RL, Morell RC. Effect of local anesthetic concentration on capillary blood flow in human skin. Regional Anesthesia 1992;17:317-321.
28. [28] Pateromichelakis S. Effects of mepivacaine, prilocaine and lidocaine on the induced constriction of the maxillofacial vasculature of the rat. Acta Anaesthesiologia Scandinavia 1991;35:60-64.
29. [29] Juhlin L, Rollman O. Vascular effects of a local anesthetic mixture in atopic dermatitis. Acta Dermatoloia et Venereologia (Stockh) 1984;64:439-440.
30. [30] Juhlin L, Evers H. EMLA: a new topical anesthetic. Advances in Dermatology 1990;5:75-91.
31. [31] Bjerring P, Andersen PH, Arendt-Nielsen L. Vascular response of human skin after analgesia with EMLA cream. British Journal of Anaesthesia 1989;63:655-660.
32. [32] Mattsson U, Jönsson A, Jontell M, Cassuto J. Digital image analysis (DIA) of colour changes in human skin exposed to standardized thermal injury and comparison with laser Doppler measurements. Computer Methods and Programs in Biomedicine 1996;50:31-42.
33. [33] Asklin B, Cassuto J. Intravesical lidocaine in severe interstitial cystitis. Case report. Scandinavian Journal of Urology and Nephrology 1989;23:311-312.
34. [34] Björck S, Dahlström A, Johansson L, Ahlman H. Treatment of the mucosa with local anaesthetics in ulcerative colitis. Agents Actions 1992; Spec No: C60-72.
35. [35] Giddon DB, Lindhe J. In vivo quantitation of local anesthetic suppression of leukocyte adherence. American Journal of Pathology 1972;68:327-338.
36. [36] Eriksson AS, Sinclair R, Cassuto J, Thomsen P. Influence of lidocaine on leukocyte function in the surgical wound. Anesthesiology 1992;77:74-78.
37. [37] Sasagawa S. Inhibitory effects of local anesthetics on migration, extracellular release of lysosomal enzyme, and superoxide anion production in human polymorphonuclear leukocytes. Immunopharmacology and Immunotoxicology 1991;13:607-622.
38. [38] Goldstein IM, Lind S, Hoffstein S, Weissmann G. influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. Reduction of lysosomal enzyme release and superoxide anion production. Journal of Experimental Medicine 1977;146:483-494.
39. [39] Gibran NS, Heimbach DM. Mediators in thermal injury. Seminars in Nephrology 1993;13:344-358.
40. [40] Luostarinen V, Evers H, Lyytikainen M-T, Scheinin A, Wahlen A. Antithrombotic effects of lidocaine and related compounds on laser-induced microvascular injury. Acta Anaesthesiologia Scandinavia 1981;25:9-11.
41. [41] Jönsson A, Brofeldt BT, Nellgård P, Cassuto J. Local anesthetics improve dermal perfusion after burn injury. Journal of Burn Care and Rehabilitation 1888;19:50-56