CD95 (Fas)-based, superantigen-dependent, CD4+ T cell-mediated down- regulation of human in vitro immunoglobulin responses

Journal of Immunology

Volumn 160, Issue 11, 1998, Pages 5231-5238

  Stohl, William ^a,d   Elliott, Julie E ^b   Lynch, David H ^c   Kiener, Peter A ^d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b AMGEN INC   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; SUPERANTIGEN;

ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNE DISEASE; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL-FREE SYSTEM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DOWN-REGULATION; ENTEROTOXINS; FAS LIGAND PROTEIN; HEMOLYTIC PLAQUE TECHNIQUE; HUMANS; IMMUNOGLOBULINS; INTERLEUKIN-2; LIGANDS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; LYMPHOCYTE COUNT; MEMBRANE GLYCOPROTEINS; RECOMBINANT PROTEINS; SOLUBILITY; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS;

EID: 0032102960     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Abe, J., B. L. Kotzin, K. Jujo, M. E. Melish, M. P. Glode, T. Kohsaka, and D. Y. M. Leung. 1992. Selective expansion of T cells expressing T-cell receptor variable regions Vβ2 and Vβ8 in Kawasaki disease. Proc. Natl. Acad. Sci. USA 89:4066.
2. Abe, J., B. L. Kotzin, C. Meissner, M. E. Melish, M. Takahashi, D, Fulton, F. Romagne, B. Malissen, and D. Y. M. Leung. 1993. Characterization of T cell repertoire changes in acute Kawasaki disease. J. Exp. Med. 177:791.
3. Paliard, X., S. G. West, J. A. Lafferty, J. R. Clements, J. W. Kappler, P. Marrack, and B. L. Kotzin. 1991. Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253:325.
4. Howell, M. D., J. P. Diveley, K. A. Lundeen, A. Esty, S. T. Winters, D. J. Carlo, and S. W. Brostoff. 1991. Limited T-cell receptor β-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 88:10921.
5. Friedman, S. M., D. N. Posnett, J. R. Tumang, B. C. Cole, and M. K. Crow. 1991. A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease. Arthritis Rheum. 34:468.
6. Florquin, S., Z. Amraoui, and M. Goldman. 1996. Persistent production of TH2-type cytokines and polyclonal B cell activation after chronic administration of staphylococcal enterotoxin B in mice. J. Autoimmun. 9:609.
7. Tumang, J. R., J.-L. Zhou, D. Gietl, M. K. Crow, K. B. Elkon, and S. M. Friedman, 1996. T helper cell-dependent, microbial superantigen-mediated B cell activation in vivo. Autoimtnunity 24:247.
8. Stohl, W., J. E. Elliott, and P. S. Linsley. 1994. Human T cell-dependent B cell differentiation induced by staphylococcal superanligens. J. Immunol. 153:117.
9. Stohl, W., and J. E. Elliott. 1995. Differential human T cell-dependent B cell differentiation induced by staphylococcal superantigens (SAg): regulatory role for SAg-dependent B cell cytolysis. J. Immunol. 155:1838.
10. Pinto, M., M. Torten, and S. C. Birnbaum. 1978. Suppression of the in vivo humoral and cellular immune response by staphylococcal enterotoxin B (SEB). Transplantation 25:320.
11. Smith, B. G., and H. M. Johnson. 1975. The effect of staphylococcal enterotoxins on the primary in vitro immune response. J. Immunol. 115:575.
12. Poindexter, N. J., and P. M. Schlievert. 1986. Suppression of immunoglobulinsecreting cells from human peripheral blood by toxic-shock-syndrome toxin-1. J. Infect. Dis. 153:772.
13. Moseley, A. B., and D. P. Huston. 1991. Mechanism of Staphylococcus aureus exotoxin A inhibition of Ig production by human B cells. J. Immunol. 146:826.
14. Hofer, M. F., K. Newell, R. C. Duke, P. M. Schlievert, J. H. Freed, and D. Y. M. Leung. 1996. Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. Proc. Natl. Acad. Sci. USA 93:5425.
15. Stohl, W., D. N. Posnett, and N. Chiorazzi. 1987. Induction of T cell-dependent B cell differentiation by anti-CD3 monoclonal antibodies. J. Immunol. 138:1667.
16. Gronowicz, E., A. Coutinho, and F. Melchers. 1976. A plaque assay for all cells secreting Ig of a given type or class. Eur. J. Immunol. 6:588.
17. Alderson, M. R., T. W. Tough, S. Braddy, T. Davis-Smith, E. Roux, K. Schooley, R. E. Miller, and D. H. Lynch. 1994. Regulation of apoptosis and T cell activation by Fas-specific mAb. Int. Immunol. 6:1799.
18. Tanaka, M., T. Suda, K. Haze, N. Nakamura, K. Sato, F. Kimura, K. Motoyoshi, M. Mizuki, S. Tagawa, S. Ohga, K. Hatake, A. H. Drummond, and S. Nagata. 1996. Fas ligand in human serum. Nat. Med. 2:317.
19. Fleischer, B., and H. Schrezenmeier. 1988. T cell stimulation by staphylococcal enterotoxins: clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. J. Exp. Med. 167:1697.
20. Mollick, J. A., R. G. Cook, and R. R. Rich. 1989. Class II MHC molecules are specific receptors for Staphylococcus enterotoxin A. Science 244:817.
21. Fuleihan, R., W. Mourad, R. S. Geha, and T. Chatila. 1991. Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells. J. Imnutnol. 146:1661.
22. Mono, T., R. S. Geha, and T. A. Chatila. 1994. Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur. J. Immunol. 24:651.
23. Mooney, N. A., L. Ju, C. Brick-Ghannam, and D. J. Charron. 1994. Bacterial superantigen signaling via HLA class II on human B lymphocytes. Mol. Immunol. 31:675.
24. Stashenko, P., L. M. Nadler, R. Hardy, and S. F. Schlossman. 1981. Expression of cell surface markers after human B lymphocyte activation. Proc. Natl. Acad. Sci. USA 78:3848.
25. + cytotoxic T cells. Proc. Natl. Acad. Sci. USA 91:4185.
26. Rothstein, T. L., J. K. M. Wang, D. J. Panka, L. C. Foote, Z. Wang, B. Stanger, H. Cui, S.-T. Ju, and A. Marshak-Rothstein. 1995. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 374:163.
27. + T cells. Nature 376:181.
28. Miyawaki, T., T. Uehara, R. Nibu, T. Tsuji, A. Yachie, S. Yonehara, and N. Taniguchi. 1992. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol. 149:3753.
29. Daniel, P. T., and P. H. Krammer. 1994. Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells. J. Immunol. 152:5624.
30. Mysler, E., P. Bini, J. Drappa, P. Ramos, S. M. Friedman, P. H. Krammer, and K. B. Elkon. 1994. The apoptosis-1/Fas protein in human systemic lupus erythematosus. J. Clin. Invest. 93:1029.
31. Kayagaki, N., A. Kawasaki, T. Ebata, H. Ohmoto, S. Ikeda, S. Inoue, K. Yoshino, K. Okumura, and H. Yagita. 1995. Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182:1777.
32. Mariani, S. M., B. Batiba, C. Bäumler, and P. H. Krammer. 1995. Regulation of cell surface APO-1/Fas (CD95) ligand expression by metalloproteases. Eur. J. Immunol. 25:2303.
33. + T cells apoptosis: a possible mechanism of bystander cell death in HIV infection. J. Immunol. 158:2456.
34. Kiener, P. A., P. M. Davis, B. M. Rankin, S. J. Klebanoff, J. A. Ledbetter, G. C. Starling, and W. C. Liles. 1997. Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation. J. Immunol. 159:1594.
35. Mourad, W., P. Scholl, A. Diaz, R. Geha, and T. Chatila. 1989. The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. J. Exp. Med. 170:2011.
36. Crow, M. K., G. Zagon, Z. Chu, B. Ravina, J. R. Tumang, B. C. Cole, and S. M. Friedman. 1992. Human B cell differentiation induced by microbial superantigens: unselected peripheral blood lymphocytes secrete polyclonal immunoglobulin in response to Mycoplasma arthritidis mitogen. Autoimmunity 14:23.
37. Martinez-Arends, A., E. Astoul, M. Lafage, and M. Lafon. 1995. Activation of human tonsil lymphocytes by rabies virus nucleocapsid superantigen. Clin. Immunol. Immunopathol. 77:177.
38. Martensson, C., P. Ifversen, C. A. K. Borrebaeck, and R. Carlsson. 1995. Enhancement of specific immunoglobulin production in SCID-hu-PBL mice after in vitro priming of human B cells with superantigen. Immunology 86:224.
39. Fleischer, B., R. Gerardy-Schahn, B. Metzroth, S. Carrel, D. Gerlach, and W. Köhler. 1991. An evolutionary conserved mechanism of T cell activation by microbial toxins: evidence for different affinities of T cell receptor-toxin interaction. J. Immunol. 146:11.
40. Garrone, P., E.-M. Neidhardt, E. Garcia, L. Galibert, C. van Kooten, and J. Banchereau. 1995. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182:1265.
41. Koopman, G., R. M. J. Keehnen, E. Lindhout, D. F. H. Zhou, C. de Groot, and S. T. Pals. 1997. Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95-induced apoptosis. Eur. J. Immunol. 27:1.
42. Holder, M. J., H. Wang, A. E. Milner, M. Casamayor, R. Armitage, M. K. Spriggs, W. C. Fanslow, I. C. M. MacLennan, C. D. Gregory, and J. Gordon. 1993. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction. Eur. J. Immunol. 23:2368.
43. Lederman, S., M. J. Yellin, A. M. Cleary, A. Pernis, G. Inghirami, L. E. Cohn, L. R. Covey, J. J. Lee, P. Rothman, and L. Chess. 1994. T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death. J. Immunol. 152:2163.
44. Tsubata, T., J. Wu, and T. Honjo. 1993. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40. Nature 364:645.
45. Cleary, A. M., S. M. Fortune, M. J. Yellin, L. Chess, and S. Lederman. 1995. Opposing roles of CD95 (Fas/APO-1) and CD40 in the death and rescue of human low density tonsillar B cells. J. Immunol. 155:3329.
46. Lagresle, C., C. Bella, P. T. Daniel, P. H. Krammer, and T. Defrance. 1995. Regulation of germinal center B cell differentiation: role of the human APO-1/Fas (CD95) molecule. J. Immunol. 154:5746.
47. Schattner, E. J., K. B. Elkon, D.-H. Yoo, J. Tumang, P. H. Krammer, M. K. Crow, and S. M. Friedman. 1995. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway. J. Exp. Med. 182:1557.
48. + T cells that induces contact-dependent B cell differentiation (help). J. Exp. Med. 175:1091.
49. + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181:1293.
50. Ramsdell, F., M. S. Seaman, R. E. Miller, T. W. Tough, M. R. Alderson, and D. H. Lynch. 1994. gld/gld mice are unable to express a functional ligand for Fas. Eur. J. Immunol. 24:928.
51. + T cell-mediated cytotoxicity. J. Immunol. 152:1127.
52. + lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway. Proc. Natl. Acad. Sci. USA 92:11225.
53. Wiley, S. R., K. Schooley, P. J. Smolak, W. S. Din, C.-P. Huang, J. K. Nicholl, G. R. Sutherland, T. D. Smith, C. Rauch, C. A. Smith, and R. G. Goodwin. 1995. Identification and characterization of a new member of the TNF family that induced apoptosis. Immunity 3:673.
54. Pitti, R. M., S. A. Marsters, S. Ruppert, C. J. Donahue, A. Moore, and A. Ashkenazi. 1996. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271:12687.
55. Bodmer, J.-L., K. Burns, P. Schneider, K. Hofmann, V. Steiner, M. Thome, T. Bornand, M. Hahne, M. Schröter, K. Becker, A. Wilson, L. E. French, J. L. Browning, H. R. MacDonald, and J. Tschopp. 1997. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95). Immunity 6:79.
56. + T cells. J. Immunol. 150:3873.
57. + T cells. J. Clin. Invest. 95:564.
58. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
59. Adachi, M., R. Watanabe-Fukunaga, and S. Nagata, 1993. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA 90:1756.
60. Wu, J., T. Zhou, J. He, and J. D. Mountz. 1993. Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene. J. Exp. Med. 178:461.
61. Chu, J.-L., J. Drappa, A. Parnassa, and K. B. Elkon. 1993. The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the relrotransposon. ETn. J. Exp. Med. 178:723.
62. Lynch, D. H., M. L. Watson, M. R. Alderson, P. R. Baum, R. E. Miller, T. Tough, M. Gibson, T. Davis-Smith, C. A. Smith, K. Hunter, D. Bhat, W. Din, R. G. Goodwin, and M. F. Seidin. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1:131.
63. Takahashi, T., M. Tanaka, C. I. Brannan, N. A. Jenkins, N. G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969.
64. Cohen, P. L., and R. A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
65. Rieux-Laucat, F., F. Le Deist, C. Hivroz, I. A. G. Roberts, K. M. Debatin, A. Fischer, and J. P. de Villartay. 1995. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268:1347.
66. Fisher, G. H., F. J. Rosenberg, S. E. Straus, J. K. Dale, L. A. Middleton, A. Y. Lin, W. Strober, M. J. Lenardo, and J. M. Puck. 1995. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81:935.
67. Drappa, J., A. K. Vaishnaw, K. E. Sullivan, J.-L. Chu, and K. B. Elkon. 1996. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J. Med. 335:1643.
68. Wu, J., J. Wilson, J. He, L. Xiang, P. H. Schur, and J. D. Mountz. 1996. Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. J. Clin. Invest. 98:1107.